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Gene: ZNF432 |
Gene summary for ZNF432 |
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Gene information | Species | Human | Gene symbol | ZNF432 | Gene ID | 9668 |
Gene name | zinc finger protein 432 | |
Gene Alias | ZNF432 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R4I3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9668 | ZNF432 | HCC1 | Human | Liver | HCC | 1.05e-03 | 1.14e+00 | 0.5336 |
9668 | ZNF432 | HCC2 | Human | Liver | HCC | 6.04e-28 | 4.61e+00 | 0.5341 |
9668 | ZNF432 | HCC5 | Human | Liver | HCC | 4.41e-11 | 1.37e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF432 | TREG | Lung | AIS | NOA1,BTN3A1,GTF2H3, etc. | 1.00e-01 | ![]() |
ZNF432 | CD4TN | Lung | AIS | NOA1,BTN3A1,GTF2H3, etc. | 2.01e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF432 | SNV | Missense_Mutation | c.1351N>T | p.His451Tyr | p.H451Y | O94892 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF432 | SNV | Missense_Mutation | rs769922751 | c.148N>G | p.Gln50Glu | p.Q50E | O94892 | protein_coding | tolerated(0.13) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZNF432 | SNV | Missense_Mutation | rs200665019 | c.1934N>A | p.Arg645Gln | p.R645Q | O94892 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF432 | SNV | Missense_Mutation | c.793N>C | p.Glu265Gln | p.E265Q | O94892 | protein_coding | deleterious(0.03) | benign(0.153) | TCGA-D8-A1JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
ZNF432 | SNV | Missense_Mutation | c.1015N>T | p.His339Tyr | p.H339Y | O94892 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF432 | SNV | Missense_Mutation | c.1078G>C | p.Val360Leu | p.V360L | O94892 | protein_coding | tolerated(1) | benign(0.001) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
ZNF432 | SNV | Missense_Mutation | rs777285542 | c.464C>G | p.Ser155Cys | p.S155C | O94892 | protein_coding | tolerated(0.12) | benign(0.346) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ZNF432 | SNV | Missense_Mutation | c.346C>G | p.Gln116Glu | p.Q116E | O94892 | protein_coding | tolerated(0.78) | benign(0.05) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ZNF432 | insertion | In_Frame_Ins | novel | c.151_152insGCTTCG | p.Gln50_Val51insGlyPhe | p.Q50_V51insGF | O94892 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF432 | insertion | Frame_Shift_Ins | novel | c.149_150insGGAGAGAAGCCCTACATCTGTAGTGAATGTGGGAA | p.Val51GlufsTer60 | p.V51Efs*60 | O94892 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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