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Gene: ZNF417 |
Gene summary for ZNF417 |
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Gene information | Species | Human | Gene symbol | ZNF417 | Gene ID | 147687 |
Gene name | zinc finger protein 417 | |
Gene Alias | ZNF417 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | M0R230 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
147687 | ZNF417 | HCC1 | Human | Liver | HCC | 8.69e-32 | 2.82e+00 | 0.5336 |
147687 | ZNF417 | HCC2 | Human | Liver | HCC | 7.39e-40 | 2.62e+00 | 0.5341 |
147687 | ZNF417 | HCC5 | Human | Liver | HCC | 1.12e-67 | 3.15e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF417 | SNV | Missense_Mutation | novel | c.441N>A | p.Phe147Leu | p.F147L | Q8TAU3 | protein_coding | tolerated(0.17) | benign(0) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF417 | SNV | Missense_Mutation | novel | c.1672C>A | p.Gln558Lys | p.Q558K | Q8TAU3 | protein_coding | tolerated(0.12) | benign(0) | TCGA-AN-A0XV-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZNF417 | SNV | Missense_Mutation | rs776841345 | c.158C>T | p.Ser53Leu | p.S53L | Q8TAU3 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-D8-A27L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin+cuclophosphamide | SD |
ZNF417 | SNV | Missense_Mutation | c.1525N>C | p.Val509Leu | p.V509L | Q8TAU3 | protein_coding | tolerated(0.45) | benign(0.005) | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
ZNF417 | insertion | In_Frame_Ins | novel | c.866_867insAAGATGTCACCGTAG | p.Val289_His290insArgCysHisArgSer | p.V289_H290insRCHRS | Q8TAU3 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF417 | SNV | Missense_Mutation | c.704N>G | p.Thr235Ser | p.T235S | Q8TAU3 | protein_coding | tolerated(0.34) | benign(0) | TCGA-EX-A69M-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF417 | SNV | Missense_Mutation | c.683N>G | p.Ile228Ser | p.I228S | Q8TAU3 | protein_coding | tolerated(0.11) | benign(0) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF417 | SNV | Missense_Mutation | c.1036N>G | p.His346Asp | p.H346D | Q8TAU3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZNF417 | SNV | Missense_Mutation | c.1433G>A | p.Cys478Tyr | p.C478Y | Q8TAU3 | protein_coding | tolerated(0.54) | benign(0) | TCGA-A6-6137-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD | |
ZNF417 | SNV | Missense_Mutation | rs534115229 | c.1394C>T | p.Ala465Val | p.A465V | Q8TAU3 | protein_coding | deleterious(0.04) | benign(0.02) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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