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Gene: ZNF397 |
Gene summary for ZNF397 |
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Gene information | Species | Human | Gene symbol | ZNF397 | Gene ID | 84307 |
Gene name | zinc finger protein 397 | |
Gene Alias | ZNF47 | |
Cytomap | 18q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NF99 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84307 | ZNF397 | LZE2T | Human | Esophagus | ESCC | 5.45e-03 | 3.26e-01 | 0.082 |
84307 | ZNF397 | LZE4T | Human | Esophagus | ESCC | 3.03e-04 | 2.06e-01 | 0.0811 |
84307 | ZNF397 | LZE5T | Human | Esophagus | ESCC | 2.51e-02 | 1.86e-01 | 0.0514 |
84307 | ZNF397 | LZE7T | Human | Esophagus | ESCC | 2.51e-07 | 3.79e-01 | 0.0667 |
84307 | ZNF397 | LZE20T | Human | Esophagus | ESCC | 2.04e-02 | 8.30e-02 | 0.0662 |
84307 | ZNF397 | LZE22T | Human | Esophagus | ESCC | 1.81e-02 | 1.86e-01 | 0.068 |
84307 | ZNF397 | LZE24T | Human | Esophagus | ESCC | 3.15e-05 | 2.23e-01 | 0.0596 |
84307 | ZNF397 | P1T-E | Human | Esophagus | ESCC | 3.00e-07 | 2.59e-01 | 0.0875 |
84307 | ZNF397 | P2T-E | Human | Esophagus | ESCC | 6.15e-24 | 4.02e-01 | 0.1177 |
84307 | ZNF397 | P4T-E | Human | Esophagus | ESCC | 2.14e-15 | 4.07e-01 | 0.1323 |
84307 | ZNF397 | P5T-E | Human | Esophagus | ESCC | 2.91e-06 | 9.04e-02 | 0.1327 |
84307 | ZNF397 | P8T-E | Human | Esophagus | ESCC | 2.06e-18 | 2.73e-01 | 0.0889 |
84307 | ZNF397 | P9T-E | Human | Esophagus | ESCC | 8.20e-16 | 3.60e-01 | 0.1131 |
84307 | ZNF397 | P10T-E | Human | Esophagus | ESCC | 1.03e-23 | 4.40e-01 | 0.116 |
84307 | ZNF397 | P11T-E | Human | Esophagus | ESCC | 3.54e-06 | 2.01e-01 | 0.1426 |
84307 | ZNF397 | P12T-E | Human | Esophagus | ESCC | 6.14e-27 | 4.72e-01 | 0.1122 |
84307 | ZNF397 | P15T-E | Human | Esophagus | ESCC | 2.12e-10 | 2.84e-01 | 0.1149 |
84307 | ZNF397 | P16T-E | Human | Esophagus | ESCC | 5.79e-15 | 2.92e-01 | 0.1153 |
84307 | ZNF397 | P17T-E | Human | Esophagus | ESCC | 6.85e-03 | 1.54e-01 | 0.1278 |
84307 | ZNF397 | P20T-E | Human | Esophagus | ESCC | 2.42e-09 | 2.66e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF397 | SNV | Missense_Mutation | novel | c.1180N>A | p.Glu394Lys | p.E394K | Q8NF99 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A7-A3IZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ZNF397 | SNV | Missense_Mutation | c.1166G>C | p.Arg389Thr | p.R389T | Q8NF99 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF397 | SNV | Missense_Mutation | rs746286942 | c.1078N>T | p.Arg360Trp | p.R360W | Q8NF99 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF397 | SNV | Missense_Mutation | c.1096N>A | p.Glu366Lys | p.E366K | Q8NF99 | protein_coding | tolerated(0.12) | probably_damaging(0.998) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
ZNF397 | insertion | In_Frame_Ins | novel | c.156_157insAAG | p.Gln52_Phe53insLys | p.Q52_F53insK | Q8NF99 | protein_coding | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF397 | insertion | Frame_Shift_Ins | novel | c.158_159insACTCATCTTTCTTATTACAAGTA | p.Phe53LeufsTer24 | p.F53Lfs*24 | Q8NF99 | protein_coding | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF397 | deletion | Frame_Shift_Del | novel | c.46delN | p.Pro16LeufsTer6 | p.P16Lfs*6 | Q8NF99 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZNF397 | SNV | Missense_Mutation | c.527N>T | p.Ser176Phe | p.S176F | Q8NF99 | protein_coding | tolerated(0.07) | benign(0.135) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF397 | insertion | Frame_Shift_Ins | novel | c.600_601insT | p.Glu201Ter | p.E201* | Q8NF99 | protein_coding | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF397 | SNV | Missense_Mutation | c.1014N>T | p.Glu338Asp | p.E338D | Q8NF99 | protein_coding | deleterious(0.02) | probably_damaging(0.92) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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