![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF385D |
Gene summary for ZNF385D |
![]() |
Gene information | Species | Human | Gene symbol | ZNF385D | Gene ID | 79750 |
Gene name | zinc finger protein 385D | |
Gene Alias | ZNF659 | |
Cytomap | 3p24.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H6B1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79750 | ZNF385D | ATC11 | Human | Thyroid | ATC | 1.60e-07 | 5.69e-01 | 0.3386 |
79750 | ZNF385D | ATC12 | Human | Thyroid | ATC | 1.21e-04 | 1.33e-01 | 0.34 |
79750 | ZNF385D | ATC2 | Human | Thyroid | ATC | 3.71e-05 | 5.05e-01 | 0.34 |
79750 | ZNF385D | ATC3 | Human | Thyroid | ATC | 5.52e-09 | 5.41e-01 | 0.338 |
79750 | ZNF385D | ATC4 | Human | Thyroid | ATC | 1.63e-06 | 1.89e-01 | 0.34 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF385D | SNV | Missense_Mutation | c.1156N>A | p.Ala386Thr | p.A386T | Q9H6B1 | protein_coding | tolerated(1) | benign(0) | TCGA-A8-A079-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
ZNF385D | SNV | Missense_Mutation | novel | c.1048G>A | p.Ala350Thr | p.A350T | Q9H6B1 | protein_coding | tolerated(0.07) | benign(0.009) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF385D | SNV | Missense_Mutation | c.881N>A | p.Arg294Lys | p.R294K | Q9H6B1 | protein_coding | deleterious(0.01) | probably_damaging(0.935) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF385D | SNV | Missense_Mutation | novel | c.115N>C | p.Phe39Leu | p.F39L | Q9H6B1 | protein_coding | deleterious(0.03) | possibly_damaging(0.827) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF385D | SNV | Missense_Mutation | novel | c.743N>A | p.Gly248Glu | p.G248E | Q9H6B1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF385D | SNV | Missense_Mutation | c.1129N>T | p.Arg377Trp | p.R377W | Q9H6B1 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF385D | SNV | Missense_Mutation | c.502N>A | p.Val168Ile | p.V168I | Q9H6B1 | protein_coding | tolerated(0.47) | benign(0.007) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF385D | SNV | Missense_Mutation | novel | c.338N>T | p.Ala113Val | p.A113V | Q9H6B1 | protein_coding | deleterious(0) | benign(0.048) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ZNF385D | SNV | Missense_Mutation | c.604N>T | p.Arg202Trp | p.R202W | Q9H6B1 | protein_coding | deleterious(0) | possibly_damaging(0.719) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF385D | SNV | Missense_Mutation | novel | c.1033N>C | p.Ala345Pro | p.A345P | Q9H6B1 | protein_coding | tolerated(0.22) | possibly_damaging(0.785) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
79750 | ZNF385D | NA | duloxetine | DULOXETINE | 29407288,28696415 |
Page: 1 |