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Gene: ZNF382 |
Gene summary for ZNF382 |
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Gene information | Species | Human | Gene symbol | ZNF382 | Gene ID | 84911 |
Gene name | zinc finger protein 382 | |
Gene Alias | KS1 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96SR6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84911 | ZNF382 | PTC05 | Human | Thyroid | PTC | 2.31e-02 | 1.26e-01 | 0.2065 |
84911 | ZNF382 | PTC07 | Human | Thyroid | PTC | 2.29e-02 | 5.21e-02 | 0.2044 |
84911 | ZNF382 | ATC13 | Human | Thyroid | ATC | 2.22e-48 | 7.99e-01 | 0.34 |
84911 | ZNF382 | ATC5 | Human | Thyroid | ATC | 2.24e-42 | 8.57e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF382 | INCAF | Thyroid | ATC | DNMT3A,HIF3A,RSPH9, etc. | 1.01e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF382 | SNV | Missense_Mutation | novel | c.713N>T | p.Arg238Ile | p.R238I | Q96SR6 | protein_coding | deleterious(0.01) | benign(0.146) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF382 | SNV | Missense_Mutation | rs747367431 | c.947N>A | p.Arg316Gln | p.R316Q | Q96SR6 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF382 | SNV | Missense_Mutation | c.1276C>T | p.His426Tyr | p.H426Y | Q96SR6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
ZNF382 | SNV | Missense_Mutation | rs746468500 | c.487N>A | p.Asp163Asn | p.D163N | Q96SR6 | protein_coding | deleterious(0.04) | benign(0) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
ZNF382 | insertion | Nonsense_Mutation | novel | c.758_759insCAGAAAGACCAAACTTTGTGATTAGAGAGTTGGAACTTTT | p.Ser254ArgfsTer8 | p.S254Rfs*8 | Q96SR6 | protein_coding | TCGA-A8-A08X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | PD | ||
ZNF382 | insertion | Frame_Shift_Ins | novel | c.549_550insGATTGGCA | p.Asn184AspfsTer42 | p.N184Dfs*42 | Q96SR6 | protein_coding | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
ZNF382 | SNV | Missense_Mutation | novel | c.477N>T | p.Glu159Asp | p.E159D | Q96SR6 | protein_coding | tolerated(0.17) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF382 | SNV | Missense_Mutation | c.874G>A | p.Glu292Lys | p.E292K | Q96SR6 | protein_coding | tolerated(0.07) | benign(0.026) | TCGA-JW-A5VJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF382 | SNV | Missense_Mutation | c.178G>A | p.Glu60Lys | p.E60K | Q96SR6 | protein_coding | deleterious(0) | possibly_damaging(0.587) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF382 | SNV | Missense_Mutation | c.1013N>T | p.Ala338Val | p.A338V | Q96SR6 | protein_coding | tolerated(0.26) | benign(0.031) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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