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Gene: ZNF346 |
Gene summary for ZNF346 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF346 | Gene ID | 23567 |
Gene name | zinc finger protein 346 | |
Gene Alias | JAZ | |
Cytomap | 5q35.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B7Z4N4 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23567 | ZNF346 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.43e-02 | 1.66e-02 | -0.1917 |
23567 | ZNF346 | HCC1_Meng | Human | Liver | HCC | 1.14e-09 | -6.44e-03 | 0.0246 |
23567 | ZNF346 | HCC1 | Human | Liver | HCC | 8.77e-04 | 2.51e+00 | 0.5336 |
23567 | ZNF346 | HCC2 | Human | Liver | HCC | 3.45e-10 | 2.79e+00 | 0.5341 |
23567 | ZNF346 | HCC5 | Human | Liver | HCC | 7.11e-05 | 6.37e-01 | 0.4932 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Endometrium | AEH: Atypical endometrial hyperplasia | |
EEC: Endometrioid Cancer | ||
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF346 | SNV | Missense_Mutation | novel | c.580N>G | p.Thr194Ala | p.T194A | Q9UL40 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF346 | SNV | Missense_Mutation | c.525N>C | p.Gln175His | p.Q175H | Q9UL40 | protein_coding | tolerated(0.06) | probably_damaging(0.953) | TCGA-D8-A1JP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
ZNF346 | SNV | Missense_Mutation | rs201400452 | c.661G>A | p.Asp221Asn | p.D221N | Q9UL40 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF346 | SNV | Missense_Mutation | c.581C>T | p.Thr194Ile | p.T194I | Q9UL40 | protein_coding | deleterious(0.03) | benign(0.1) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF346 | SNV | Missense_Mutation | c.377T>C | p.Val126Ala | p.V126A | Q9UL40 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ZNF346 | SNV | Missense_Mutation | c.633N>A | p.Phe211Leu | p.F211L | Q9UL40 | protein_coding | deleterious(0.03) | possibly_damaging(0.734) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF346 | SNV | Missense_Mutation | novel | c.906N>T | p.Gln302His | p.Q302H | Q9UL40 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.904) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZNF346 | SNV | Missense_Mutation | c.319C>T | p.Leu107Phe | p.L107F | Q9UL40 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF346 | SNV | Missense_Mutation | novel | c.324N>G | p.Ile108Met | p.I108M | Q9UL40 | protein_coding | deleterious(0.04) | probably_damaging(0.98) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF346 | SNV | Missense_Mutation | novel | c.625G>T | p.Asp209Tyr | p.D209Y | Q9UL40 | protein_coding | deleterious(0.01) | probably_damaging(0.922) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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