![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF34 |
Gene summary for ZNF34 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF34 | Gene ID | 80778 |
Gene name | zinc finger protein 34 | |
Gene Alias | KOX32 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0C4DG42 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80778 | ZNF34 | HCC1_Meng | Human | Liver | HCC | 3.03e-10 | 1.32e-02 | 0.0246 |
80778 | ZNF34 | HCC1 | Human | Liver | HCC | 8.58e-14 | 1.90e+00 | 0.5336 |
80778 | ZNF34 | HCC2 | Human | Liver | HCC | 3.59e-24 | 1.86e+00 | 0.5341 |
80778 | ZNF34 | HCC5 | Human | Liver | HCC | 1.37e-16 | 1.13e+00 | 0.4932 |
80778 | ZNF34 | S014 | Human | Liver | HCC | 7.38e-08 | 3.03e-01 | 0.2254 |
80778 | ZNF34 | S015 | Human | Liver | HCC | 2.77e-06 | 2.81e-01 | 0.2375 |
80778 | ZNF34 | S016 | Human | Liver | HCC | 1.61e-04 | 2.18e-01 | 0.2243 |
80778 | ZNF34 | S028 | Human | Liver | HCC | 6.61e-03 | 1.71e-01 | 0.2503 |
80778 | ZNF34 | S029 | Human | Liver | HCC | 6.25e-07 | 2.53e-01 | 0.2581 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063835 | Thyroid | PTC | transcription by RNA polymerase III | 23/5968 | 46/18723 | 7.89e-03 | 3.33e-02 | 23 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF34 | SNV | Missense_Mutation | novel | c.53N>G | p.Asn18Ser | p.N18S | Q8IZ26 | protein_coding | tolerated(0.72) | benign(0) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
ZNF34 | SNV | Missense_Mutation | c.974A>G | p.His325Arg | p.H325R | Q8IZ26 | protein_coding | deleterious(0) | benign(0.444) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF34 | SNV | Missense_Mutation | c.371N>G | p.Glu124Gly | p.E124G | Q8IZ26 | protein_coding | tolerated(0.24) | benign(0.278) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
ZNF34 | SNV | Missense_Mutation | c.1313N>G | p.Gln438Arg | p.Q438R | Q8IZ26 | protein_coding | tolerated(0.13) | possibly_damaging(0.608) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF34 | SNV | Missense_Mutation | c.1076N>C | p.Gly359Ala | p.G359A | Q8IZ26 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
ZNF34 | SNV | Missense_Mutation | novel | c.1430N>A | p.Cys477Tyr | p.C477Y | Q8IZ26 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF34 | SNV | Missense_Mutation | c.1248N>T | p.Glu416Asp | p.E416D | Q8IZ26 | protein_coding | deleterious(0.01) | possibly_damaging(0.894) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
ZNF34 | SNV | Missense_Mutation | c.943A>G | p.Thr315Ala | p.T315A | Q8IZ26 | protein_coding | tolerated(1) | benign(0) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF34 | SNV | Missense_Mutation | c.67G>A | p.Ala23Thr | p.A23T | Q8IZ26 | protein_coding | tolerated(0.32) | benign(0.366) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF34 | SNV | Missense_Mutation | c.1369N>G | p.Ser457Gly | p.S457G | Q8IZ26 | protein_coding | deleterious(0) | benign(0.005) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |