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Gene: ZNF33B |
Gene summary for ZNF33B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF33B | Gene ID | 7582 |
| Gene name | zinc finger protein 33B | |
| Gene Alias | KOX2 | |
| Cytomap | 10q11.21 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q06732 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7582 | ZNF33B | S43 | Human | Liver | Cirrhotic | 2.12e-05 | -1.15e-01 | -0.0187 |
| 7582 | ZNF33B | HCC1_Meng | Human | Liver | HCC | 1.08e-21 | -1.14e-01 | 0.0246 |
| 7582 | ZNF33B | HCC2_Meng | Human | Liver | HCC | 8.93e-18 | 7.08e-02 | 0.0107 |
| 7582 | ZNF33B | HCC2 | Human | Liver | HCC | 8.40e-11 | 3.08e+00 | 0.5341 |
| 7582 | ZNF33B | HCC5 | Human | Liver | HCC | 7.27e-04 | 2.26e+00 | 0.4932 |
| 7582 | ZNF33B | Pt13.a | Human | Liver | HCC | 1.98e-02 | -1.47e-01 | 0.021 |
| 7582 | ZNF33B | Pt13.c | Human | Liver | HCC | 6.24e-03 | -1.81e-01 | 0.0076 |
| 7582 | ZNF33B | S028 | Human | Liver | HCC | 2.91e-04 | 5.63e-01 | 0.2503 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF33B | SNV | Missense_Mutation | c.1526A>G | p.Lys509Arg | p.K509R | Q06732 | protein_coding | tolerated(0.1) | probably_damaging(0.989) | TCGA-A2-A0D0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| ZNF33B | SNV | Missense_Mutation | c.32N>T | p.Ser11Leu | p.S11L | Q06732 | protein_coding | tolerated(0.1) | benign(0.1) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF33B | SNV | Missense_Mutation | rs770021674 | c.607N>T | p.Arg203Cys | p.R203C | Q06732 | protein_coding | tolerated(0.18) | benign(0.224) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZNF33B | SNV | Missense_Mutation | novel | c.166N>T | p.His56Tyr | p.H56Y | Q06732 | protein_coding | tolerated(0.06) | benign(0.018) | TCGA-OL-A66L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZNF33B | SNV | Missense_Mutation | novel | c.830T>G | p.Phe277Cys | p.F277C | Q06732 | protein_coding | tolerated(0.44) | possibly_damaging(0.467) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ZNF33B | SNV | Missense_Mutation | novel | c.926A>T | p.Asn309Ile | p.N309I | Q06732 | protein_coding | deleterious(0.02) | possibly_damaging(0.548) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF33B | SNV | Missense_Mutation | novel | c.245N>G | p.Phe82Cys | p.F82C | Q06732 | protein_coding | tolerated(0.11) | probably_damaging(0.99) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF33B | SNV | Missense_Mutation | c.1037N>A | p.Arg346Gln | p.R346Q | Q06732 | protein_coding | tolerated(0.6) | possibly_damaging(0.869) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
| ZNF33B | SNV | Missense_Mutation | rs565643232 | c.1834N>C | p.Asn612His | p.N612H | Q06732 | protein_coding | deleterious(0.01) | possibly_damaging(0.726) | TCGA-AA-A02K-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD |
| ZNF33B | SNV | Missense_Mutation | c.1382G>T | p.Arg461Ile | p.R461I | Q06732 | protein_coding | deleterious(0.03) | probably_damaging(0.985) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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