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Gene: ZNF330 |
Gene summary for ZNF330 |
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Gene information | Species | Human | Gene symbol | ZNF330 | Gene ID | 27309 |
Gene name | zinc finger protein 330 | |
Gene Alias | HSA6591 | |
Cytomap | 4q31.21 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | B4DFG9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27309 | ZNF330 | LZE7T | Human | Esophagus | ESCC | 1.98e-02 | -1.10e-02 | 0.0667 |
27309 | ZNF330 | LZE8T | Human | Esophagus | ESCC | 3.03e-11 | 2.28e-01 | 0.067 |
27309 | ZNF330 | LZE20T | Human | Esophagus | ESCC | 1.17e-05 | 3.38e-02 | 0.0662 |
27309 | ZNF330 | LZE22T | Human | Esophagus | ESCC | 6.05e-07 | 2.34e-01 | 0.068 |
27309 | ZNF330 | LZE24T | Human | Esophagus | ESCC | 1.51e-19 | 5.94e-02 | 0.0596 |
27309 | ZNF330 | LZE21T | Human | Esophagus | ESCC | 2.18e-04 | 2.40e-02 | 0.0655 |
27309 | ZNF330 | LZE6T | Human | Esophagus | ESCC | 2.06e-04 | 1.35e-02 | 0.0845 |
27309 | ZNF330 | P1T-E | Human | Esophagus | ESCC | 1.02e-02 | 1.24e-01 | 0.0875 |
27309 | ZNF330 | P2T-E | Human | Esophagus | ESCC | 1.13e-28 | 5.30e-01 | 0.1177 |
27309 | ZNF330 | P4T-E | Human | Esophagus | ESCC | 1.36e-23 | 3.74e-01 | 0.1323 |
27309 | ZNF330 | P5T-E | Human | Esophagus | ESCC | 1.99e-12 | 1.97e-01 | 0.1327 |
27309 | ZNF330 | P8T-E | Human | Esophagus | ESCC | 3.39e-23 | 3.17e-01 | 0.0889 |
27309 | ZNF330 | P9T-E | Human | Esophagus | ESCC | 1.82e-11 | 2.29e-01 | 0.1131 |
27309 | ZNF330 | P10T-E | Human | Esophagus | ESCC | 2.31e-22 | 1.65e-01 | 0.116 |
27309 | ZNF330 | P11T-E | Human | Esophagus | ESCC | 3.50e-10 | 2.96e-01 | 0.1426 |
27309 | ZNF330 | P12T-E | Human | Esophagus | ESCC | 3.32e-22 | 5.78e-01 | 0.1122 |
27309 | ZNF330 | P15T-E | Human | Esophagus | ESCC | 1.16e-15 | 3.06e-01 | 0.1149 |
27309 | ZNF330 | P16T-E | Human | Esophagus | ESCC | 8.43e-20 | 2.33e-01 | 0.1153 |
27309 | ZNF330 | P17T-E | Human | Esophagus | ESCC | 1.98e-13 | 4.74e-01 | 0.1278 |
27309 | ZNF330 | P20T-E | Human | Esophagus | ESCC | 9.03e-11 | 6.72e-02 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF330 | SNV | Missense_Mutation | c.477N>A | p.Phe159Leu | p.F159L | Q9Y3S2 | protein_coding | deleterious(0.04) | benign(0.331) | TCGA-AR-A1AI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD | |
ZNF330 | SNV | Missense_Mutation | rs375158856 | c.779A>G | p.Asp260Gly | p.D260G | Q9Y3S2 | protein_coding | tolerated_low_confidence(0.67) | benign(0) | TCGA-BH-A0BL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ZNF330 | SNV | Missense_Mutation | c.374N>A | p.Thr125Asn | p.T125N | Q9Y3S2 | protein_coding | tolerated(0.33) | benign(0.062) | TCGA-E9-A1R7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | fareston | SD | |
ZNF330 | insertion | Frame_Shift_Ins | rs770975379 | c.14dupA | p.Thr6AspfsTer8 | p.T6Dfs*8 | Q9Y3S2 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF330 | deletion | Frame_Shift_Del | novel | c.252delN | p.Lys85SerfsTer84 | p.K85Sfs*84 | Q9Y3S2 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ZNF330 | SNV | Missense_Mutation | c.124N>G | p.Cys42Gly | p.C42G | Q9Y3S2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF330 | SNV | Missense_Mutation | novel | c.472N>G | p.Gln158Glu | p.Q158E | Q9Y3S2 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF330 | SNV | Missense_Mutation | c.805N>A | p.Asp269Asn | p.D269N | Q9Y3S2 | protein_coding | tolerated_low_confidence(0.37) | benign(0.333) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF330 | SNV | Missense_Mutation | c.695N>T | p.Ser232Phe | p.S232F | Q9Y3S2 | protein_coding | deleterious(0) | possibly_damaging(0.697) | TCGA-AY-4071-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF330 | SNV | Missense_Mutation | c.23C>T | p.Ala8Val | p.A8V | Q9Y3S2 | protein_coding | tolerated(0.12) | probably_damaging(0.992) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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