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Gene: ZNF322 |
Gene summary for ZNF322 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF322 | Gene ID | 79692 |
| Gene name | zinc finger protein 322 | |
| Gene Alias | HCG12 | |
| Cytomap | 6p22.2 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024QZZ4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79692 | ZNF322 | LZE2D | Human | Esophagus | HGIN | 1.21e-03 | 7.90e-01 | 0.0642 |
| 79692 | ZNF322 | LZE4T | Human | Esophagus | ESCC | 1.01e-09 | 2.81e-01 | 0.0811 |
| 79692 | ZNF322 | LZE7T | Human | Esophagus | ESCC | 1.71e-12 | 9.07e-01 | 0.0667 |
| 79692 | ZNF322 | LZE8T | Human | Esophagus | ESCC | 2.73e-07 | 2.47e-01 | 0.067 |
| 79692 | ZNF322 | LZE20T | Human | Esophagus | ESCC | 6.52e-08 | 3.82e-01 | 0.0662 |
| 79692 | ZNF322 | LZE24T | Human | Esophagus | ESCC | 4.96e-22 | 1.03e+00 | 0.0596 |
| 79692 | ZNF322 | LZE21T | Human | Esophagus | ESCC | 1.81e-02 | 6.74e-01 | 0.0655 |
| 79692 | ZNF322 | LZE6T | Human | Esophagus | ESCC | 4.22e-03 | 2.63e-01 | 0.0845 |
| 79692 | ZNF322 | P1T-E | Human | Esophagus | ESCC | 2.02e-11 | 5.82e-01 | 0.0875 |
| 79692 | ZNF322 | P2T-E | Human | Esophagus | ESCC | 2.14e-46 | 7.26e-01 | 0.1177 |
| 79692 | ZNF322 | P4T-E | Human | Esophagus | ESCC | 2.65e-37 | 1.47e+00 | 0.1323 |
| 79692 | ZNF322 | P5T-E | Human | Esophagus | ESCC | 1.02e-06 | 1.51e-01 | 0.1327 |
| 79692 | ZNF322 | P8T-E | Human | Esophagus | ESCC | 2.02e-20 | 3.85e-01 | 0.0889 |
| 79692 | ZNF322 | P9T-E | Human | Esophagus | ESCC | 1.87e-13 | 3.50e-01 | 0.1131 |
| 79692 | ZNF322 | P10T-E | Human | Esophagus | ESCC | 3.37e-19 | 3.53e-01 | 0.116 |
| 79692 | ZNF322 | P11T-E | Human | Esophagus | ESCC | 1.75e-16 | 5.09e-01 | 0.1426 |
| 79692 | ZNF322 | P12T-E | Human | Esophagus | ESCC | 5.30e-54 | 1.62e+00 | 0.1122 |
| 79692 | ZNF322 | P15T-E | Human | Esophagus | ESCC | 1.03e-20 | 6.84e-01 | 0.1149 |
| 79692 | ZNF322 | P16T-E | Human | Esophagus | ESCC | 6.51e-30 | 4.67e-01 | 0.1153 |
| 79692 | ZNF322 | P17T-E | Human | Esophagus | ESCC | 1.73e-08 | 3.69e-01 | 0.1278 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00198277 | Esophagus | HGIN | stem cell population maintenance | 39/2587 | 131/18723 | 1.63e-06 | 6.14e-05 | 39 |
| GO:00987278 | Esophagus | HGIN | maintenance of cell number | 39/2587 | 134/18723 | 3.02e-06 | 1.03e-04 | 39 |
| GO:20000362 | Esophagus | HGIN | regulation of stem cell population maintenance | 11/2587 | 33/18723 | 3.55e-03 | 3.26e-02 | 11 |
| GO:009872714 | Esophagus | ESCC | maintenance of cell number | 90/8552 | 134/18723 | 3.94e-07 | 5.43e-06 | 90 |
| GO:001982714 | Esophagus | ESCC | stem cell population maintenance | 88/8552 | 131/18723 | 5.23e-07 | 6.97e-06 | 88 |
| GO:20000361 | Esophagus | ESCC | regulation of stem cell population maintenance | 23/8552 | 33/18723 | 4.57e-03 | 1.78e-02 | 23 |
| GO:00987272 | Liver | HCC | maintenance of cell number | 77/7958 | 134/18723 | 3.32e-04 | 2.33e-03 | 77 |
| GO:00198272 | Liver | HCC | stem cell population maintenance | 75/7958 | 131/18723 | 4.58e-04 | 3.04e-03 | 75 |
| GO:009872710 | Thyroid | PTC | maintenance of cell number | 63/5968 | 134/18723 | 1.73e-04 | 1.32e-03 | 63 |
| GO:00198279 | Thyroid | PTC | stem cell population maintenance | 61/5968 | 131/18723 | 3.01e-04 | 2.12e-03 | 61 |
| GO:009872722 | Thyroid | ATC | maintenance of cell number | 70/6293 | 134/18723 | 6.45e-06 | 6.69e-05 | 70 |
| GO:001982722 | Thyroid | ATC | stem cell population maintenance | 67/6293 | 131/18723 | 2.48e-05 | 2.16e-04 | 67 |
| GO:20000363 | Thyroid | ATC | regulation of stem cell population maintenance | 18/6293 | 33/18723 | 1.06e-02 | 3.84e-02 | 18 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF322 | BN | Skin | ADJ | LNPK,MRPL38,UPK3A, etc. | 1.78e-02 |  |
| ZNF322 | CD4TN | Skin | Healthy | LNPK,MRPL38,UPK3A, etc. | 2.86e-02 |  |
| ZNF322 | pDC | Skin | SCCIS | LNPK,MRPL38,UPK3A, etc. | 6.14e-02 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF322 | SNV | Missense_Mutation | c.1165G>A | p.Glu389Lys | p.E389K | Q6U7Q0 | protein_coding | tolerated(0.15) | benign(0) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| ZNF322 | SNV | Missense_Mutation | novel | c.4T>C | p.Tyr2His | p.Y2H | Q6U7Q0 | protein_coding | tolerated_low_confidence(0.27) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ZNF322 | SNV | Missense_Mutation | novel | c.954N>T | p.Glu318Asp | p.E318D | Q6U7Q0 | protein_coding | deleterious(0.04) | benign(0.037) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
| ZNF322 | SNV | Missense_Mutation | novel | c.922N>A | p.Leu308Ile | p.L308I | Q6U7Q0 | protein_coding | deleterious(0) | benign(0.262) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
| ZNF322 | SNV | Missense_Mutation | novel | c.248N>T | p.Ser83Ile | p.S83I | Q6U7Q0 | protein_coding | deleterious(0.01) | benign(0.083) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZNF322 | SNV | Missense_Mutation | novel | c.5N>G | p.Tyr2Cys | p.Y2C | Q6U7Q0 | protein_coding | tolerated_low_confidence(0.14) | benign(0.001) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF322 | SNV | Missense_Mutation | novel | c.797N>T | p.Pro266Leu | p.P266L | Q6U7Q0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| ZNF322 | SNV | Missense_Mutation | c.662N>A | p.Arg221Gln | p.R221Q | Q6U7Q0 | protein_coding | deleterious(0.05) | possibly_damaging(0.886) | TCGA-A5-A0GA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | taxol | PD | |
| ZNF322 | SNV | Missense_Mutation | novel | c.18N>T | p.Glu6Asp | p.E6D | Q6U7Q0 | protein_coding | tolerated(0.25) | benign(0.031) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF322 | SNV | Missense_Mutation | novel | c.81N>T | p.Lys27Asn | p.K27N | Q6U7Q0 | protein_coding | tolerated(0.13) | benign(0.012) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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