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Gene: ZNF296 |
Gene summary for ZNF296 |
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Gene information | Species | Human | Gene symbol | ZNF296 | Gene ID | 162979 |
Gene name | zinc finger protein 296 | |
Gene Alias | ZFP296 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8WUU4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
162979 | ZNF296 | LZE20T | Human | Esophagus | ESCC | 3.20e-07 | 1.43e-01 | 0.0662 |
162979 | ZNF296 | LZE24T | Human | Esophagus | ESCC | 7.29e-06 | 2.59e-01 | 0.0596 |
162979 | ZNF296 | P1T-E | Human | Esophagus | ESCC | 4.20e-03 | 5.48e-01 | 0.0875 |
162979 | ZNF296 | P2T-E | Human | Esophagus | ESCC | 4.81e-10 | 1.42e-01 | 0.1177 |
162979 | ZNF296 | P4T-E | Human | Esophagus | ESCC | 2.57e-03 | 2.32e-01 | 0.1323 |
162979 | ZNF296 | P5T-E | Human | Esophagus | ESCC | 2.76e-11 | 3.62e-01 | 0.1327 |
162979 | ZNF296 | P8T-E | Human | Esophagus | ESCC | 3.66e-35 | 6.66e-01 | 0.0889 |
162979 | ZNF296 | P9T-E | Human | Esophagus | ESCC | 1.31e-04 | 8.78e-02 | 0.1131 |
162979 | ZNF296 | P10T-E | Human | Esophagus | ESCC | 2.26e-16 | 1.98e-01 | 0.116 |
162979 | ZNF296 | P11T-E | Human | Esophagus | ESCC | 4.09e-12 | 9.76e-01 | 0.1426 |
162979 | ZNF296 | P12T-E | Human | Esophagus | ESCC | 7.22e-12 | 3.00e-01 | 0.1122 |
162979 | ZNF296 | P15T-E | Human | Esophagus | ESCC | 3.71e-18 | 4.84e-01 | 0.1149 |
162979 | ZNF296 | P16T-E | Human | Esophagus | ESCC | 3.96e-10 | 7.18e-02 | 0.1153 |
162979 | ZNF296 | P20T-E | Human | Esophagus | ESCC | 1.88e-29 | 8.57e-01 | 0.1124 |
162979 | ZNF296 | P22T-E | Human | Esophagus | ESCC | 1.42e-06 | 6.18e-02 | 0.1236 |
162979 | ZNF296 | P23T-E | Human | Esophagus | ESCC | 1.66e-11 | 5.02e-01 | 0.108 |
162979 | ZNF296 | P24T-E | Human | Esophagus | ESCC | 4.41e-13 | 7.77e-02 | 0.1287 |
162979 | ZNF296 | P26T-E | Human | Esophagus | ESCC | 6.35e-12 | 1.71e-01 | 0.1276 |
162979 | ZNF296 | P27T-E | Human | Esophagus | ESCC | 6.02e-14 | 5.20e-01 | 0.1055 |
162979 | ZNF296 | P28T-E | Human | Esophagus | ESCC | 1.59e-30 | 7.54e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF296 | PLA | Lung | Healthy | DDIT4,SOCS3,ANAPC16, etc. | 6.81e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF296 | SNV | Missense_Mutation | rs139536353 | c.1420N>A | p.Glu474Lys | p.E474K | Q8WUU4 | protein_coding | tolerated_low_confidence(0.12) | benign(0) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ZNF296 | SNV | Missense_Mutation | c.1309G>T | p.Gly437Cys | p.G437C | Q8WUU4 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AR-A1AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD | |
ZNF296 | SNV | Missense_Mutation | rs572467590 | c.1264G>A | p.Ala422Thr | p.A422T | Q8WUU4 | protein_coding | tolerated(0.13) | benign(0.227) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF296 | SNV | Missense_Mutation | novel | c.558G>C | p.Gln186His | p.Q186H | Q8WUU4 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-MY-A913-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF296 | SNV | Missense_Mutation | rs567972762 | c.1145N>A | p.Arg382His | p.R382H | Q8WUU4 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF296 | SNV | Missense_Mutation | novel | c.634N>T | p.Pro212Ser | p.P212S | Q8WUU4 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF296 | SNV | Missense_Mutation | c.1039C>A | p.Pro347Thr | p.P347T | Q8WUU4 | protein_coding | tolerated(0.05) | possibly_damaging(0.622) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF296 | SNV | Missense_Mutation | novel | c.752G>A | p.Arg251His | p.R251H | Q8WUU4 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
ZNF296 | SNV | Missense_Mutation | c.466N>T | p.Ala156Ser | p.A156S | Q8WUU4 | protein_coding | tolerated(0.12) | benign(0.031) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF296 | SNV | Missense_Mutation | novel | c.520N>T | p.Arg174Cys | p.R174C | Q8WUU4 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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