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Gene: ZNF275 |
Gene summary for ZNF275 |
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Gene information | Species | Human | Gene symbol | ZNF275 | Gene ID | 10838 |
Gene name | zinc finger protein 275 | |
Gene Alias | ZNF275 | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A6NFS0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10838 | ZNF275 | HCC1_Meng | Human | Liver | HCC | 5.33e-39 | 8.40e-02 | 0.0246 |
10838 | ZNF275 | HCC2_Meng | Human | Liver | HCC | 1.18e-15 | 1.39e-01 | 0.0107 |
10838 | ZNF275 | HCC2 | Human | Liver | HCC | 7.25e-05 | 3.01e+00 | 0.5341 |
10838 | ZNF275 | S027 | Human | Liver | HCC | 8.20e-08 | 8.23e-01 | 0.2446 |
10838 | ZNF275 | S028 | Human | Liver | HCC | 8.54e-23 | 8.12e-01 | 0.2503 |
10838 | ZNF275 | S029 | Human | Liver | HCC | 3.50e-19 | 8.25e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF275 | SNV | Missense_Mutation | c.362N>C | p.Arg121Thr | p.R121T | protein_coding | deleterious(0) | possibly_damaging(0.691) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | ||
ZNF275 | SNV | Missense_Mutation | rs782812244 | c.332N>A | p.Arg111Gln | p.R111Q | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-VS-A9UR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF275 | SNV | Missense_Mutation | rs782458088 | c.835G>A | p.Gly279Arg | p.G279R | protein_coding | deleterious(0.03) | probably_damaging(0.962) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF275 | SNV | Missense_Mutation | c.656A>G | p.Lys219Arg | p.K219R | protein_coding | tolerated(0.56) | benign(0.005) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF275 | SNV | Missense_Mutation | novel | c.294N>C | p.Glu98Asp | p.E98D | protein_coding | deleterious(0.02) | benign(0.211) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF275 | SNV | Missense_Mutation | novel | c.449N>T | p.Ser150Ile | p.S150I | protein_coding | tolerated(0.88) | benign(0.054) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ZNF275 | SNV | Missense_Mutation | c.847N>T | p.His283Tyr | p.H283Y | protein_coding | deleterious(0) | possibly_damaging(0.533) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF275 | SNV | Missense_Mutation | novel | c.935G>T | p.Arg312Leu | p.R312L | protein_coding | deleterious(0.01) | benign(0.191) | TCGA-D5-6536-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fu | SD | |
ZNF275 | SNV | Missense_Mutation | c.299N>G | p.His100Arg | p.H100R | protein_coding | tolerated(0.33) | benign(0.015) | TCGA-F4-6461-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
ZNF275 | SNV | Missense_Mutation | rs368798771 | c.461C>T | p.Ala154Val | p.A154V | protein_coding | tolerated(0.35) | benign(0.007) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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