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Gene: ZNF264 |
Gene summary for ZNF264 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZNF264 | Gene ID | 9422 |
Gene name | zinc finger protein 264 | |
Gene Alias | ZNF264 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O43296 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9422 | ZNF264 | HCC1_Meng | Human | Liver | HCC | 1.34e-19 | -4.27e-02 | 0.0246 |
9422 | ZNF264 | HCC2_Meng | Human | Liver | HCC | 3.77e-08 | -2.54e-03 | 0.0107 |
9422 | ZNF264 | HCC1 | Human | Liver | HCC | 1.14e-19 | 3.31e+00 | 0.5336 |
9422 | ZNF264 | HCC2 | Human | Liver | HCC | 2.37e-32 | 3.52e+00 | 0.5341 |
9422 | ZNF264 | HCC5 | Human | Liver | HCC | 4.23e-33 | 2.60e+00 | 0.4932 |
9422 | ZNF264 | male-WTA | Human | Thyroid | PTC | 2.55e-24 | 1.90e-01 | 0.1037 |
9422 | ZNF264 | PTC01 | Human | Thyroid | PTC | 6.16e-10 | 1.14e-01 | 0.1899 |
9422 | ZNF264 | PTC04 | Human | Thyroid | PTC | 1.36e-20 | 2.35e-01 | 0.1927 |
9422 | ZNF264 | PTC05 | Human | Thyroid | PTC | 1.00e-10 | 3.98e-01 | 0.2065 |
9422 | ZNF264 | PTC06 | Human | Thyroid | PTC | 9.10e-20 | 4.29e-01 | 0.2057 |
9422 | ZNF264 | PTC07 | Human | Thyroid | PTC | 1.30e-22 | 2.81e-01 | 0.2044 |
9422 | ZNF264 | ATC12 | Human | Thyroid | ATC | 3.21e-20 | 1.91e-01 | 0.34 |
9422 | ZNF264 | ATC13 | Human | Thyroid | ATC | 7.48e-31 | 5.89e-01 | 0.34 |
9422 | ZNF264 | ATC2 | Human | Thyroid | ATC | 2.61e-08 | 8.00e-01 | 0.34 |
9422 | ZNF264 | ATC4 | Human | Thyroid | ATC | 2.96e-12 | 2.63e-01 | 0.34 |
9422 | ZNF264 | ATC5 | Human | Thyroid | ATC | 1.37e-36 | 6.41e-01 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF264 | CD8TEFF | Breast | DCIS | RABGAP1,PRPSAP1,AC093010.2, etc. | 1.19e-01 |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF264 | SNV | Missense_Mutation | c.1556N>T | p.Ser519Leu | p.S519L | O43296 | protein_coding | deleterious(0.01) | benign(0.105) | TCGA-EK-A2RL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | taxol | PD | |
ZNF264 | SNV | Missense_Mutation | c.1856G>C | p.Arg619Thr | p.R619T | O43296 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.95) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF264 | SNV | Missense_Mutation | rs771516876 | c.974N>A | p.Arg325Gln | p.R325Q | O43296 | protein_coding | tolerated(0.09) | probably_damaging(0.997) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF264 | SNV | Missense_Mutation | rs201494065 | c.1507N>T | p.Arg503Trp | p.R503W | O43296 | protein_coding | tolerated(0.06) | probably_damaging(0.999) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZNF264 | SNV | Missense_Mutation | rs193291802 | c.1414C>T | p.Arg472Cys | p.R472C | O43296 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
ZNF264 | SNV | Missense_Mutation | rs115695746 | c.1649N>A | p.Arg550His | p.R550H | O43296 | protein_coding | tolerated(0.42) | probably_damaging(0.93) | TCGA-AA-3814-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF264 | SNV | Missense_Mutation | c.332N>A | p.Gly111Glu | p.G111E | O43296 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF264 | SNV | Missense_Mutation | c.1415N>T | p.Arg472Leu | p.R472L | O43296 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZNF264 | SNV | Missense_Mutation | novel | c.182A>G | p.Glu61Gly | p.E61G | O43296 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF264 | SNV | Missense_Mutation | rs147396716 | c.259G>A | p.Asp87Asn | p.D87N | O43296 | protein_coding | tolerated(0.22) | benign(0.006) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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