Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZNF226

Gene summary for ZNF226

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZNF226

Gene ID

7769

Gene namezinc finger protein 226
Gene AliasZNF226
Cytomap19q13.31
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

A0A024R0P4


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7769ZNF226LZE24THumanEsophagusESCC5.45e-101.38e-010.0596
7769ZNF226P2T-EHumanEsophagusESCC3.09e-071.00e-010.1177
7769ZNF226P4T-EHumanEsophagusESCC1.37e-092.60e-010.1323
7769ZNF226P5T-EHumanEsophagusESCC4.96e-099.46e-020.1327
7769ZNF226P8T-EHumanEsophagusESCC1.26e-335.97e-010.0889
7769ZNF226P10T-EHumanEsophagusESCC5.43e-456.57e-010.116
7769ZNF226P11T-EHumanEsophagusESCC9.38e-073.34e-010.1426
7769ZNF226P12T-EHumanEsophagusESCC1.02e-182.33e-010.1122
7769ZNF226P15T-EHumanEsophagusESCC2.11e-101.85e-010.1149
7769ZNF226P16T-EHumanEsophagusESCC1.32e-096.40e-020.1153
7769ZNF226P20T-EHumanEsophagusESCC5.95e-042.34e-010.1124
7769ZNF226P21T-EHumanEsophagusESCC4.07e-085.59e-020.1617
7769ZNF226P22T-EHumanEsophagusESCC1.80e-151.81e-010.1236
7769ZNF226P23T-EHumanEsophagusESCC9.59e-051.10e-010.108
7769ZNF226P24T-EHumanEsophagusESCC2.24e-071.14e-010.1287
7769ZNF226P26T-EHumanEsophagusESCC2.91e-182.48e-010.1276
7769ZNF226P27T-EHumanEsophagusESCC1.13e-142.09e-010.1055
7769ZNF226P28T-EHumanEsophagusESCC6.54e-107.99e-020.1149
7769ZNF226P30T-EHumanEsophagusESCC8.66e-041.74e-010.137
7769ZNF226P31T-EHumanEsophagusESCC1.64e-111.58e-010.1251
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ZNF226MLUMBreastADJMS4A7,KISS1R,SPTSSB, etc.3.70e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF226MLUMBreastPrecancerMS4A7,KISS1R,SPTSSB, etc.3.29e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF226MSCBreastDCISNME2,BX255923.2,CSF3, etc.3.42e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF226PFIBLiverCirrhoticSCD5,FABP4,GPSM1, etc.1.83e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF226ADIPOSkinADJSARAF,ZNF688,P2RY14, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF226DPCSkinHealthySARAF,ZNF688,P2RY14, etc.8.71e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF226MSC.PVASkinHealthySARAF,ZNF688,P2RY14, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF226PTCThyroidHealthyPEX3,IMMP1L,SERPINB6, etc.2.03e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ZNF226SNVMissense_Mutationc.850N>Cp.Glu284Glnp.E284QQ9NYT6protein_codingtolerated(0.22)benign(0.118)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
ZNF226SNVMissense_Mutationnovelc.1520N>Gp.Glu507Glyp.E507GQ9NYT6protein_codingdeleterious(0.02)probably_damaging(0.999)TCGA-C8-A8HQ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ZNF226SNVMissense_Mutationnovelc.2154N>Tp.Gln718Hisp.Q718HQ9NYT6protein_codingtolerated(0.1)probably_damaging(0.997)TCGA-C8-A8HQ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ZNF226SNVMissense_Mutationnovelc.766N>Cp.Glu256Glnp.E256QQ9NYT6protein_codingdeleterious(0.04)benign(0.213)TCGA-E2-A1LG-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
ZNF226deletionFrame_Shift_Delnovelc.151delNp.Phe52SerfsTer8p.F52Sfs*8Q9NYT6protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
ZNF226deletionFrame_Shift_Delnovelc.971delNp.His325IlefsTer6p.H325Ifs*6Q9NYT6protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
ZNF226SNVMissense_Mutationnovelc.1967N>Tp.Ala656Valp.A656VQ9NYT6protein_codingdeleterious(0.03)benign(0.059)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ZNF226SNVMissense_Mutationc.1549N>Tp.His517Tyrp.H517YQ9NYT6protein_codingtolerated(1)probably_damaging(0.923)TCGA-C5-A1MH-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycisplatinPD
ZNF226SNVMissense_Mutationnovelc.1309C>Ap.His437Asnp.H437NQ9NYT6protein_codingdeleterious(0)probably_damaging(0.999)TCGA-C5-A7X5-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycarboplatinPD
ZNF226SNVMissense_Mutationnovelc.1264N>Ap.Glu422Lysp.E422KQ9NYT6protein_codingtolerated(0.22)benign(0.036)TCGA-DS-A1OB-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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