Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZNF148

Gene summary for ZNF148

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZNF148

Gene ID

7707

Gene namezinc finger protein 148
Gene AliasBERF-1
Cytomap3q21.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

Q9UQR1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7707ZNF148CA_HPV_1HumanCervixCC4.09e-02-1.34e-010.0264
7707ZNF148CCI_1HumanCervixCC1.87e-061.28e+000.528
7707ZNF148CCI_2HumanCervixCC5.61e-091.09e+000.5249
7707ZNF148CCI_3HumanCervixCC7.36e-221.54e+000.516
7707ZNF148HTA11_3410_2000001011HumanColorectumAD1.45e-30-7.95e-010.0155
7707ZNF148HTA11_2487_2000001011HumanColorectumSER7.96e-08-4.54e-01-0.1808
7707ZNF148HTA11_2951_2000001011HumanColorectumAD9.00e-04-8.17e-010.0216
7707ZNF148HTA11_3361_2000001011HumanColorectumAD3.03e-08-6.70e-01-0.1207
7707ZNF148HTA11_83_2000001011HumanColorectumSER2.40e-05-5.05e-01-0.1526
7707ZNF148HTA11_696_2000001011HumanColorectumAD8.94e-08-4.56e-01-0.1464
7707ZNF148HTA11_866_2000001011HumanColorectumAD4.58e-06-3.74e-01-0.1001
7707ZNF148HTA11_5212_2000001011HumanColorectumAD4.40e-05-5.73e-01-0.2061
7707ZNF148HTA11_546_2000001011HumanColorectumAD1.48e-02-4.90e-01-0.0842
7707ZNF148HTA11_9341_2000001011HumanColorectumSER3.56e-02-5.64e-01-0.00410000000000005
7707ZNF148HTA11_866_3004761011HumanColorectumAD9.95e-13-6.64e-010.096
7707ZNF148HTA11_9408_2000001011HumanColorectumAD5.26e-04-9.47e-010.0451
7707ZNF148HTA11_8622_2000001021HumanColorectumSER4.83e-03-7.04e-010.0528
7707ZNF148HTA11_10711_2000001011HumanColorectumAD1.19e-03-4.45e-010.0338
7707ZNF148HTA11_7696_3000711011HumanColorectumAD1.19e-13-5.66e-010.0674
7707ZNF148HTA11_6818_2000001011HumanColorectumAD3.10e-06-4.35e-010.0112
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00309019CervixCCmidbrain development26/231190/187232.12e-053.82e-0426
GO:002176210CervixCCsubstantia nigra development16/231144/187233.81e-055.99e-0416
GO:00488579CervixCCneural nucleus development18/231164/187235.42e-045.23e-0318
GO:0021762ColorectumADsubstantia nigra development21/391844/187236.60e-051.07e-0321
GO:0048857ColorectumADneural nucleus development27/391864/187239.57e-051.45e-0327
GO:0030901ColorectumADmidbrain development32/391890/187239.45e-048.95e-0332
GO:00217621ColorectumSERsubstantia nigra development21/289744/187234.77e-072.40e-0521
GO:00488571ColorectumSERneural nucleus development26/289764/187231.09e-065.11e-0526
GO:00309011ColorectumSERmidbrain development29/289790/187235.50e-051.30e-0329
GO:00217622ColorectumMSSsubstantia nigra development21/346744/187239.54e-062.33e-0421
GO:00488572ColorectumMSSneural nucleus development26/346764/187233.19e-056.30e-0426
GO:00309012ColorectumMSSmidbrain development31/346790/187232.36e-043.24e-0331
GO:00217624ColorectumFAPsubstantia nigra development15/262244/187236.22e-046.82e-0315
GO:00488574ColorectumFAPneural nucleus development19/262264/187238.94e-049.08e-0319
GO:00309014ColorectumFAPmidbrain development24/262290/187231.12e-031.08e-0224
GO:00488575ColorectumCRCneural nucleus development17/207864/187234.59e-046.70e-0317
GO:00217625ColorectumCRCsubstantia nigra development13/207844/187237.05e-049.17e-0313
GO:00309015ColorectumCRCmidbrain development21/207890/187237.06e-049.17e-0321
GO:0021762111EsophagusESCCsubstantia nigra development35/855244/187234.40e-064.69e-0535
GO:004885718EsophagusESCCneural nucleus development44/855264/187231.59e-041.05e-0344
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ZNF148CAFBreastDCISTFRC,LIPA,SCD, etc.7.27e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF148LYMENDBreastDCISTFRC,LIPA,SCD, etc.3.43e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF148NKLungADJGAREM1,IKZF1,PIP4K2A, etc.2.07e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZNF148ALVMACLungHealthyGPR107,FGD3,PRPF8, etc.4.24e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ZNF148SNVMissense_Mutationc.1333N>Ap.Asp445Asnp.D445NQ9UQR1protein_codingdeleterious(0.01)benign(0.435)TCGA-A8-A0A7-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ZNF148SNVMissense_Mutationnovelc.2326N>Ap.Asp776Asnp.D776NQ9UQR1protein_codingdeleterious(0.02)benign(0.023)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
ZNF148SNVMissense_Mutationc.304N>Gp.Gln102Glup.Q102EQ9UQR1protein_codingtolerated(0.38)benign(0.122)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
ZNF148SNVMissense_Mutationc.740N>Tp.Arg247Ilep.R247IQ9UQR1protein_codingdeleterious(0)probably_damaging(0.997)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZNF148SNVMissense_Mutationc.2132N>Tp.Ser711Phep.S711FQ9UQR1protein_codingdeleterious(0.01)benign(0)TCGA-D8-A1JP-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
ZNF148insertionFrame_Shift_Insnovelc.1856_1857insAp.Asn619LysfsTer2p.N619Kfs*2Q9UQR1protein_codingTCGA-C8-A1HN-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ZNF148SNVMissense_Mutationrs762634520c.1423C>Tp.Arg475Trpp.R475WQ9UQR1protein_codingdeleterious(0)benign(0.005)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ZNF148SNVMissense_Mutationnovelc.1142C>Tp.Ala381Valp.A381VQ9UQR1protein_codingtolerated(0.2)benign(0.012)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ZNF148SNVMissense_Mutationc.1669N>Ap.Glu557Lysp.E557KQ9UQR1protein_codingdeleterious(0.01)possibly_damaging(0.506)TCGA-BI-A0VS-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ZNF148SNVMissense_Mutationc.2373N>Cp.Gln791Hisp.Q791HQ9UQR1protein_codingdeleterious(0)possibly_damaging(0.737)TCGA-C5-A1M6-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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