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Gene: ZNF143 |
Gene summary for ZNF143 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF143 | Gene ID | 7702 |
| Gene name | zinc finger protein 143 | |
| Gene Alias | SBF | |
| Cytomap | 11p15.4 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P52747 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7702 | ZNF143 | LZE4T | Human | Esophagus | ESCC | 1.88e-04 | 2.70e-01 | 0.0811 |
| 7702 | ZNF143 | LZE7T | Human | Esophagus | ESCC | 6.03e-04 | 2.46e-01 | 0.0667 |
| 7702 | ZNF143 | LZE8T | Human | Esophagus | ESCC | 3.09e-02 | 9.53e-02 | 0.067 |
| 7702 | ZNF143 | LZE24T | Human | Esophagus | ESCC | 3.70e-03 | 1.05e-01 | 0.0596 |
| 7702 | ZNF143 | LZE21T | Human | Esophagus | ESCC | 5.46e-03 | 2.16e-01 | 0.0655 |
| 7702 | ZNF143 | LZE6T | Human | Esophagus | ESCC | 1.52e-03 | 1.98e-01 | 0.0845 |
| 7702 | ZNF143 | P2T-E | Human | Esophagus | ESCC | 5.21e-18 | 2.65e-01 | 0.1177 |
| 7702 | ZNF143 | P4T-E | Human | Esophagus | ESCC | 1.38e-04 | 1.32e-01 | 0.1323 |
| 7702 | ZNF143 | P5T-E | Human | Esophagus | ESCC | 4.45e-07 | 7.92e-02 | 0.1327 |
| 7702 | ZNF143 | P8T-E | Human | Esophagus | ESCC | 2.66e-14 | 1.80e-01 | 0.0889 |
| 7702 | ZNF143 | P9T-E | Human | Esophagus | ESCC | 1.87e-02 | 9.10e-02 | 0.1131 |
| 7702 | ZNF143 | P10T-E | Human | Esophagus | ESCC | 2.66e-10 | 2.18e-01 | 0.116 |
| 7702 | ZNF143 | P11T-E | Human | Esophagus | ESCC | 1.41e-04 | 1.85e-01 | 0.1426 |
| 7702 | ZNF143 | P12T-E | Human | Esophagus | ESCC | 4.49e-11 | 1.75e-01 | 0.1122 |
| 7702 | ZNF143 | P15T-E | Human | Esophagus | ESCC | 5.34e-13 | 2.78e-01 | 0.1149 |
| 7702 | ZNF143 | P16T-E | Human | Esophagus | ESCC | 1.17e-11 | 2.12e-01 | 0.1153 |
| 7702 | ZNF143 | P20T-E | Human | Esophagus | ESCC | 1.53e-09 | 2.59e-01 | 0.1124 |
| 7702 | ZNF143 | P21T-E | Human | Esophagus | ESCC | 1.61e-08 | 1.33e-01 | 0.1617 |
| 7702 | ZNF143 | P22T-E | Human | Esophagus | ESCC | 2.34e-09 | 1.03e-01 | 0.1236 |
| 7702 | ZNF143 | P23T-E | Human | Esophagus | ESCC | 6.17e-10 | 2.59e-01 | 0.108 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00063833 | Esophagus | ESCC | transcription by RNA polymerase III | 41/8552 | 46/18723 | 7.69e-10 | 1.90e-08 | 41 |
| GO:00987812 | Esophagus | ESCC | ncRNA transcription | 45/8552 | 56/18723 | 1.05e-07 | 1.72e-06 | 45 |
| GO:0006359 | Esophagus | ESCC | regulation of transcription by RNA polymerase III | 19/8552 | 22/18723 | 9.52e-05 | 6.78e-04 | 19 |
| GO:00093011 | Esophagus | ESCC | snRNA transcription | 16/8552 | 19/18723 | 6.45e-04 | 3.43e-03 | 16 |
| GO:0045945 | Esophagus | ESCC | positive regulation of transcription by RNA polymerase III | 10/8552 | 11/18723 | 2.54e-03 | 1.08e-02 | 10 |
| GO:00427951 | Esophagus | ESCC | snRNA transcription by RNA polymerase II | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF143 | CD4TN | Liver | Cirrhotic | CREM,PRIM2,SIPA1L1, etc. | 3.10e-01 |  |
| ZNF143 | CD8TCM | Liver | HCC | CREM,PRIM2,SIPA1L1, etc. | 3.88e-01 |  |
| ZNF143 | PANIN | Pancreas | PanIN | ERI2,CENPU,SCUBE2, etc. | 1.82e-02 |  |
| ZNF143 | DUCT2 | Pancreas | PanIN | ERI2,CENPU,SCUBE2, etc. | 2.46e-03 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF143 | SNV | Missense_Mutation | novel | c.337N>T | p.Asp113Tyr | p.D113Y | P52747 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF143 | SNV | Missense_Mutation | rs766025125 | c.157N>A | p.Val53Ile | p.V53I | P52747 | protein_coding | deleterious(0.04) | benign(0.063) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
| ZNF143 | SNV | Missense_Mutation | c.702N>C | p.Glu234Asp | p.E234D | P52747 | protein_coding | tolerated(0.31) | benign(0.076) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR | |
| ZNF143 | insertion | Frame_Shift_Ins | novel | c.338_339insT | p.Gly114TrpfsTer13 | p.G114Wfs*13 | P52747 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| ZNF143 | SNV | Missense_Mutation | rs768865975 | c.142N>A | p.Val48Ile | p.V48I | P52747 | protein_coding | tolerated(0.1) | benign(0.017) | TCGA-C5-A1MN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| ZNF143 | SNV | Missense_Mutation | rs775453952 | c.754N>T | p.His252Tyr | p.H252Y | P52747 | protein_coding | deleterious(0.03) | benign(0.027) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZNF143 | SNV | Missense_Mutation | c.305G>T | p.Arg102Leu | p.R102L | P52747 | protein_coding | tolerated(0.17) | benign(0.097) | TCGA-FU-A57G-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ZNF143 | SNV | Missense_Mutation | rs762077968 | c.68N>T | p.Ala23Val | p.A23V | P52747 | protein_coding | deleterious_low_confidence(0.01) | benign(0.027) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ZNF143 | SNV | Missense_Mutation | c.1324N>A | p.Asp442Asn | p.D442N | P52747 | protein_coding | deleterious(0.02) | probably_damaging(0.972) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
| ZNF143 | SNV | Missense_Mutation | c.1234N>G | p.Thr412Ala | p.T412A | P52747 | protein_coding | deleterious(0) | probably_damaging(0.931) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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