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Gene: ZNF141 |
Gene summary for ZNF141 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZNF141 | Gene ID | 7700 |
| Gene name | zinc finger protein 141 | |
| Gene Alias | D4S90 | |
| Cytomap | 4p16.3 | |
| Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q4W5N2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7700 | ZNF141 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.22e-15 | 4.29e-01 | -0.1954 |
| 7700 | ZNF141 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.48e-08 | 5.96e-01 | -0.1526 |
| 7700 | ZNF141 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.17e-09 | 5.58e-01 | -0.1464 |
| 7700 | ZNF141 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.27e-14 | 6.65e-01 | -0.059 |
| 7700 | ZNF141 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.75e-05 | 6.79e-01 | -0.1462 |
| 7700 | ZNF141 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.35e-27 | 8.70e-01 | 0.096 |
| 7700 | ZNF141 | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.43e-05 | 7.89e-01 | 0.0446 |
| 7700 | ZNF141 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.06e-06 | 6.60e-01 | 0.0528 |
| 7700 | ZNF141 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.80e-09 | 9.34e-01 | 0.0131 |
| 7700 | ZNF141 | HTA11_6818_2000001011 | Human | Colorectum | AD | 8.45e-13 | 1.09e+00 | 0.0112 |
| 7700 | ZNF141 | HTA11_11156_2000001011 | Human | Colorectum | AD | 2.23e-08 | 1.09e+00 | 0.0397 |
| 7700 | ZNF141 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.94e-27 | 1.19e+00 | 0.0588 |
| 7700 | ZNF141 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.78e-19 | 9.78e-01 | 0.3859 |
| 7700 | ZNF141 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.04e-06 | 4.92e-01 | 0.2585 |
| 7700 | ZNF141 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.70e-25 | 9.36e-01 | 0.3005 |
| 7700 | ZNF141 | A015-C-203 | Human | Colorectum | FAP | 3.41e-10 | -2.39e-01 | -0.1294 |
| 7700 | ZNF141 | A001-C-108 | Human | Colorectum | FAP | 2.61e-06 | -1.66e-01 | -0.0272 |
| 7700 | ZNF141 | A002-C-205 | Human | Colorectum | FAP | 2.67e-03 | -2.10e-01 | -0.1236 |
| 7700 | ZNF141 | A001-C-104 | Human | Colorectum | FAP | 2.13e-03 | -1.26e-01 | 0.0184 |
| 7700 | ZNF141 | A015-C-106 | Human | Colorectum | FAP | 1.00e-05 | -1.19e-01 | -0.0511 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0048736 | Colorectum | AD | appendage development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
| GO:0060173 | Colorectum | AD | limb development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
| GO:00487361 | Colorectum | SER | appendage development | 42/2897 | 172/18723 | 1.43e-03 | 1.55e-02 | 42 |
| GO:00601731 | Colorectum | SER | limb development | 42/2897 | 172/18723 | 1.43e-03 | 1.55e-02 | 42 |
| GO:0035107 | Colorectum | SER | appendage morphogenesis | 33/2897 | 138/18723 | 6.10e-03 | 4.42e-02 | 33 |
| GO:0035108 | Colorectum | SER | limb morphogenesis | 33/2897 | 138/18723 | 6.10e-03 | 4.42e-02 | 33 |
| GO:00487362 | Colorectum | MSS | appendage development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
| GO:00601732 | Colorectum | MSS | limb development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
| GO:00351071 | Colorectum | FAP | appendage morphogenesis | 35/2622 | 138/18723 | 2.74e-04 | 3.66e-03 | 35 |
| GO:00351081 | Colorectum | FAP | limb morphogenesis | 35/2622 | 138/18723 | 2.74e-04 | 3.66e-03 | 35 |
| GO:00487363 | Colorectum | FAP | appendage development | 40/2622 | 172/18723 | 7.15e-04 | 7.66e-03 | 40 |
| GO:00601733 | Colorectum | FAP | limb development | 40/2622 | 172/18723 | 7.15e-04 | 7.66e-03 | 40 |
| GO:00351072 | Colorectum | CRC | appendage morphogenesis | 32/2078 | 138/18723 | 3.77e-05 | 9.26e-04 | 32 |
| GO:00351082 | Colorectum | CRC | limb morphogenesis | 32/2078 | 138/18723 | 3.77e-05 | 9.26e-04 | 32 |
| GO:00487364 | Colorectum | CRC | appendage development | 34/2078 | 172/18723 | 5.80e-04 | 7.89e-03 | 34 |
| GO:00601734 | Colorectum | CRC | limb development | 34/2078 | 172/18723 | 5.80e-04 | 7.89e-03 | 34 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZNF141 | MAST | Breast | DCIS | HIP1R,BTAF1,FCRL3, etc. | 0.00e+00 |  |
| ZNF141 | M2MAC | Breast | DCIS | HIP1R,BTAF1,FCRL3, etc. | 2.22e-16 | |
| ZNF141 | MON | Breast | DCIS | HIP1R,BTAF1,FCRL3, etc. | 2.22e-16 | |
| ZNF141 | GC | Breast | Healthy | HIP1R,BTAF1,FCRL3, etc. | 0.00e+00 |  |
| ZNF141 | TFH | Breast | Healthy | HIP1R,BTAF1,FCRL3, etc. | 6.69e-03 | |
| ZNF141 | M2MAC | Breast | Healthy | HIP1R,BTAF1,FCRL3, etc. | 4.32e-03 | |
| ZNF141 | CD8TRM | Breast | IDC | HIP1R,BTAF1,FCRL3, etc. | 9.77e-04 |  |
| ZNF141 | CD8TEFF | Breast | Precancer | HIP1R,BTAF1,FCRL3, etc. | 4.50e-02 |  |
| ZNF141 | CD8TEX | Breast | Precancer | HIP1R,BTAF1,FCRL3, etc. | 0.00e+00 | |
| ZNF141 | CD4TN | Breast | Precancer | HIP1R,BTAF1,FCRL3, etc. | 0.00e+00 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZNF141 | SNV | Missense_Mutation | c.733C>G | p.His245Asp | p.H245D | Q15928 | protein_coding | deleterious(0) | possibly_damaging(0.869) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ZNF141 | SNV | Missense_Mutation | novel | c.670N>C | p.Glu224Gln | p.E224Q | Q15928 | protein_coding | deleterious(0.03) | probably_damaging(0.964) | TCGA-AQ-A7U7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | rituximab | CR |
| ZNF141 | deletion | Frame_Shift_Del | novel | c.515delN | p.His172ProfsTer15 | p.H172Pfs*15 | Q15928 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
| ZNF141 | SNV | Missense_Mutation | c.1328A>G | p.Lys443Arg | p.K443R | Q15928 | protein_coding | tolerated(0.95) | benign(0.005) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF141 | SNV | Missense_Mutation | c.1290N>C | p.Lys430Asn | p.K430N | Q15928 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ZNF141 | SNV | Missense_Mutation | novel | c.39N>A | p.Phe13Leu | p.F13L | Q15928 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF141 | SNV | Missense_Mutation | novel | c.928N>T | p.Pro310Ser | p.P310S | Q15928 | protein_coding | deleterious(0.03) | benign(0.437) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZNF141 | SNV | Missense_Mutation | rs782456680 | c.908N>A | p.Arg303Gln | p.R303Q | Q15928 | protein_coding | tolerated(0.12) | benign(0.329) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| ZNF141 | SNV | Missense_Mutation | rs781835417 | c.1307N>T | p.Ser436Leu | p.S436L | Q15928 | protein_coding | deleterious(0.02) | benign(0.344) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| ZNF141 | SNV | Missense_Mutation | rs782565943 | c.1163T>A | p.Ile388Asn | p.I388N | Q15928 | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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