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Gene: ZNF140 |
Gene summary for ZNF140 |
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Gene information | Species | Human | Gene symbol | ZNF140 | Gene ID | 7699 |
Gene name | zinc finger protein 140 | |
Gene Alias | pHZ-39 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P52738 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7699 | ZNF140 | LZE4T | Human | Esophagus | ESCC | 5.61e-04 | 8.75e-02 | 0.0811 |
7699 | ZNF140 | LZE24T | Human | Esophagus | ESCC | 6.60e-11 | 1.48e-01 | 0.0596 |
7699 | ZNF140 | LZE21T | Human | Esophagus | ESCC | 4.81e-03 | 2.10e-01 | 0.0655 |
7699 | ZNF140 | P1T-E | Human | Esophagus | ESCC | 6.31e-03 | 2.34e-01 | 0.0875 |
7699 | ZNF140 | P2T-E | Human | Esophagus | ESCC | 4.97e-43 | 7.18e-01 | 0.1177 |
7699 | ZNF140 | P4T-E | Human | Esophagus | ESCC | 3.33e-20 | 2.66e-01 | 0.1323 |
7699 | ZNF140 | P5T-E | Human | Esophagus | ESCC | 1.38e-03 | 9.28e-02 | 0.1327 |
7699 | ZNF140 | P8T-E | Human | Esophagus | ESCC | 5.62e-19 | 3.85e-01 | 0.0889 |
7699 | ZNF140 | P9T-E | Human | Esophagus | ESCC | 4.62e-06 | 9.17e-02 | 0.1131 |
7699 | ZNF140 | P10T-E | Human | Esophagus | ESCC | 5.01e-18 | 2.75e-01 | 0.116 |
7699 | ZNF140 | P11T-E | Human | Esophagus | ESCC | 1.14e-12 | 4.34e-01 | 0.1426 |
7699 | ZNF140 | P12T-E | Human | Esophagus | ESCC | 5.09e-14 | 2.59e-01 | 0.1122 |
7699 | ZNF140 | P15T-E | Human | Esophagus | ESCC | 3.63e-13 | 2.46e-01 | 0.1149 |
7699 | ZNF140 | P16T-E | Human | Esophagus | ESCC | 1.28e-22 | 3.27e-01 | 0.1153 |
7699 | ZNF140 | P19T-E | Human | Esophagus | ESCC | 4.19e-02 | 2.39e-01 | 0.1662 |
7699 | ZNF140 | P21T-E | Human | Esophagus | ESCC | 7.78e-13 | 2.51e-01 | 0.1617 |
7699 | ZNF140 | P22T-E | Human | Esophagus | ESCC | 1.50e-13 | 2.77e-01 | 0.1236 |
7699 | ZNF140 | P23T-E | Human | Esophagus | ESCC | 2.85e-06 | 1.70e-01 | 0.108 |
7699 | ZNF140 | P24T-E | Human | Esophagus | ESCC | 5.87e-05 | 6.21e-02 | 0.1287 |
7699 | ZNF140 | P26T-E | Human | Esophagus | ESCC | 1.99e-13 | 2.93e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF140 | SNV | Missense_Mutation | rs778373091 | c.1214N>T | p.Arg405Ile | p.R405I | P52738 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF140 | insertion | In_Frame_Ins | novel | c.836_837insCACTTCATATTATTTCAAAATTCTGTTCCAATT | p.Gly279_Lys280insThrSerTyrTyrPheLysIleLeuPheGlnPhe | p.G279_K280insTSYYFKILFQF | P52738 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF140 | insertion | Frame_Shift_Ins | novel | c.1130_1131insCATCCCAGTATTTGATCATG | p.Lys377AsnfsTer121 | p.K377Nfs*121 | P52738 | protein_coding | TCGA-BH-A0DS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
ZNF140 | SNV | Missense_Mutation | novel | c.433N>G | p.Gln145Glu | p.Q145E | P52738 | protein_coding | tolerated(1) | benign(0) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
ZNF140 | SNV | Missense_Mutation | novel | c.350N>G | p.Phe117Cys | p.F117C | P52738 | protein_coding | deleterious(0.04) | benign(0.174) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
ZNF140 | SNV | Missense_Mutation | novel | c.794N>T | p.Arg265Ile | p.R265I | P52738 | protein_coding | deleterious(0.01) | possibly_damaging(0.653) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF140 | SNV | Missense_Mutation | novel | c.39N>G | p.Ile13Met | p.I13M | P52738 | protein_coding | deleterious(0.02) | possibly_damaging(0.542) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF140 | SNV | Missense_Mutation | novel | c.215N>C | p.Lys72Thr | p.K72T | P52738 | protein_coding | tolerated(1) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF140 | SNV | Missense_Mutation | novel | c.365N>C | p.Lys122Thr | p.K122T | P52738 | protein_coding | deleterious(0.01) | probably_damaging(0.922) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ZNF140 | SNV | Missense_Mutation | rs781218697 | c.1016N>A | p.Arg339His | p.R339H | P52738 | protein_coding | tolerated(0.39) | probably_damaging(0.96) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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