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Gene: ZNF138 |
Gene summary for ZNF138 |
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Gene information | Species | Human | Gene symbol | ZNF138 | Gene ID | 7697 |
Gene name | zinc finger protein 138 | |
Gene Alias | pHZ-32 | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0A0MT90 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7697 | ZNF138 | LZE4T | Human | Esophagus | ESCC | 1.93e-06 | 1.60e-01 | 0.0811 |
7697 | ZNF138 | LZE7T | Human | Esophagus | ESCC | 2.30e-03 | 1.81e-01 | 0.0667 |
7697 | ZNF138 | LZE8T | Human | Esophagus | ESCC | 1.42e-02 | 1.68e-01 | 0.067 |
7697 | ZNF138 | LZE20T | Human | Esophagus | ESCC | 3.62e-03 | 9.85e-02 | 0.0662 |
7697 | ZNF138 | LZE24T | Human | Esophagus | ESCC | 2.08e-14 | 3.41e-01 | 0.0596 |
7697 | ZNF138 | P1T-E | Human | Esophagus | ESCC | 1.18e-12 | 3.83e-01 | 0.0875 |
7697 | ZNF138 | P2T-E | Human | Esophagus | ESCC | 2.49e-19 | 2.71e-01 | 0.1177 |
7697 | ZNF138 | P4T-E | Human | Esophagus | ESCC | 1.65e-11 | 2.96e-01 | 0.1323 |
7697 | ZNF138 | P5T-E | Human | Esophagus | ESCC | 5.58e-09 | 1.93e-01 | 0.1327 |
7697 | ZNF138 | P8T-E | Human | Esophagus | ESCC | 2.93e-08 | 1.19e-01 | 0.0889 |
7697 | ZNF138 | P9T-E | Human | Esophagus | ESCC | 1.75e-08 | 1.83e-01 | 0.1131 |
7697 | ZNF138 | P10T-E | Human | Esophagus | ESCC | 1.14e-24 | 4.15e-01 | 0.116 |
7697 | ZNF138 | P11T-E | Human | Esophagus | ESCC | 1.68e-06 | 3.44e-01 | 0.1426 |
7697 | ZNF138 | P12T-E | Human | Esophagus | ESCC | 1.19e-17 | 3.09e-01 | 0.1122 |
7697 | ZNF138 | P15T-E | Human | Esophagus | ESCC | 1.43e-19 | 4.58e-01 | 0.1149 |
7697 | ZNF138 | P16T-E | Human | Esophagus | ESCC | 2.00e-20 | 3.77e-01 | 0.1153 |
7697 | ZNF138 | P17T-E | Human | Esophagus | ESCC | 8.48e-07 | 2.52e-01 | 0.1278 |
7697 | ZNF138 | P19T-E | Human | Esophagus | ESCC | 6.88e-03 | 3.43e-01 | 0.1662 |
7697 | ZNF138 | P20T-E | Human | Esophagus | ESCC | 2.64e-21 | 2.12e-01 | 0.1124 |
7697 | ZNF138 | P21T-E | Human | Esophagus | ESCC | 4.48e-17 | 3.02e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF138 | SNV | Missense_Mutation | novel | c.386N>G | p.Gln129Arg | p.Q129R | protein_coding | deleterious(0.02) | possibly_damaging(0.452) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZNF138 | SNV | Missense_Mutation | c.438N>C | p.Lys146Asn | p.K146N | protein_coding | tolerated(0.07) | benign(0.044) | TCGA-BH-A18K-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
ZNF138 | SNV | Missense_Mutation | novel | c.184G>C | p.Glu62Gln | p.E62Q | protein_coding | deleterious(0.03) | probably_damaging(0.938) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
ZNF138 | insertion | Frame_Shift_Ins | novel | c.414_415insCCACAGGTTCTAATTCC | p.Phe139ProfsTer13 | p.F139Pfs*13 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | |||
ZNF138 | SNV | Missense_Mutation | c.894N>C | p.Gln298His | p.Q298H | protein_coding | deleterious(0) | benign(0.377) | TCGA-C5-A1BE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
ZNF138 | SNV | Missense_Mutation | c.95T>C | p.Val32Ala | p.V32A | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF138 | SNV | Missense_Mutation | rs754223101 | c.733N>T | p.Arg245Cys | p.R245C | protein_coding | deleterious(0.01) | possibly_damaging(0.764) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ZNF138 | SNV | Missense_Mutation | novel | c.416T>C | p.Phe139Ser | p.F139S | protein_coding | deleterious(0.05) | probably_damaging(0.936) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
ZNF138 | SNV | Missense_Mutation | c.437N>G | p.Lys146Arg | p.K146R | protein_coding | deleterious(0.04) | possibly_damaging(0.757) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ZNF138 | SNV | Missense_Mutation | c.451N>C | p.Phe151Leu | p.F151L | protein_coding | tolerated(0.11) | possibly_damaging(0.477) | TCGA-AG-3890-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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