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Gene: ZNF107 |
Gene summary for ZNF107 |
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Gene information | Species | Human | Gene symbol | ZNF107 | Gene ID | 51427 |
Gene name | zinc finger protein 107 | |
Gene Alias | Y8 | |
Cytomap | 7q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R5Y9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51427 | ZNF107 | LZE4T | Human | Esophagus | ESCC | 1.06e-02 | 1.61e-01 | 0.0811 |
51427 | ZNF107 | LZE7T | Human | Esophagus | ESCC | 2.05e-04 | 2.28e-01 | 0.0667 |
51427 | ZNF107 | LZE24T | Human | Esophagus | ESCC | 6.02e-13 | 3.02e-01 | 0.0596 |
51427 | ZNF107 | LZE21T | Human | Esophagus | ESCC | 3.76e-05 | 2.56e-01 | 0.0655 |
51427 | ZNF107 | P1T-E | Human | Esophagus | ESCC | 2.01e-12 | 3.94e-01 | 0.0875 |
51427 | ZNF107 | P2T-E | Human | Esophagus | ESCC | 2.86e-20 | 2.93e-01 | 0.1177 |
51427 | ZNF107 | P4T-E | Human | Esophagus | ESCC | 7.66e-13 | 2.76e-01 | 0.1323 |
51427 | ZNF107 | P5T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.57e-01 | 0.1327 |
51427 | ZNF107 | P8T-E | Human | Esophagus | ESCC | 3.52e-19 | 3.04e-01 | 0.0889 |
51427 | ZNF107 | P9T-E | Human | Esophagus | ESCC | 2.95e-04 | 1.28e-01 | 0.1131 |
51427 | ZNF107 | P10T-E | Human | Esophagus | ESCC | 5.79e-16 | 3.02e-01 | 0.116 |
51427 | ZNF107 | P12T-E | Human | Esophagus | ESCC | 1.94e-29 | 4.25e-01 | 0.1122 |
51427 | ZNF107 | P15T-E | Human | Esophagus | ESCC | 6.39e-09 | 2.26e-01 | 0.1149 |
51427 | ZNF107 | P16T-E | Human | Esophagus | ESCC | 1.35e-23 | 3.88e-01 | 0.1153 |
51427 | ZNF107 | P20T-E | Human | Esophagus | ESCC | 2.20e-12 | 2.92e-01 | 0.1124 |
51427 | ZNF107 | P21T-E | Human | Esophagus | ESCC | 5.79e-16 | 3.22e-01 | 0.1617 |
51427 | ZNF107 | P22T-E | Human | Esophagus | ESCC | 8.08e-19 | 3.22e-01 | 0.1236 |
51427 | ZNF107 | P23T-E | Human | Esophagus | ESCC | 2.94e-02 | 8.21e-02 | 0.108 |
51427 | ZNF107 | P24T-E | Human | Esophagus | ESCC | 1.08e-09 | 1.18e-01 | 0.1287 |
51427 | ZNF107 | P26T-E | Human | Esophagus | ESCC | 8.25e-06 | 1.34e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF107 | SNV | Missense_Mutation | c.1751N>G | p.Lys584Arg | p.K584R | protein_coding | tolerated(0.27) | probably_damaging(0.979) | TCGA-A2-A0SW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | PD | ||
ZNF107 | SNV | Missense_Mutation | novel | c.76C>T | p.Arg26Trp | p.R26W | protein_coding | deleterious(0.05) | probably_damaging(0.988) | TCGA-A2-A3XV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
ZNF107 | SNV | Missense_Mutation | c.1786N>A | p.Glu596Lys | p.E596K | protein_coding | tolerated(0.59) | probably_damaging(0.969) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ZNF107 | SNV | Missense_Mutation | novel | c.101N>C | p.Leu34Ser | p.L34S | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AR-A5QQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
ZNF107 | deletion | Frame_Shift_Del | novel | c.1755delN | p.Ile585MetfsTer57 | p.I585Mfs*57 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
ZNF107 | SNV | Missense_Mutation | rs201478920 | c.1823G>A | p.Arg608His | p.R608H | protein_coding | deleterious(0.01) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZNF107 | SNV | Missense_Mutation | rs748281700 | c.28N>A | p.Ala10Thr | p.A10T | protein_coding | tolerated(0.18) | probably_damaging(0.981) | TCGA-VS-A9V3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF107 | SNV | Missense_Mutation | c.1820N>G | p.His607Arg | p.H607R | protein_coding | tolerated(0.55) | benign(0.107) | TCGA-A6-6137-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD | ||
ZNF107 | SNV | Missense_Mutation | c.2442N>T | p.Glu814Asp | p.E814D | protein_coding | tolerated(0.07) | benign(0.076) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF107 | SNV | Missense_Mutation | novel | c.1607C>T | p.Pro536Leu | p.P536L | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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