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Gene: ZFYVE21 |
Gene summary for ZFYVE21 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZFYVE21 | Gene ID | 79038 |
Gene name | zinc finger FYVE-type containing 21 | |
Gene Alias | HCVP7TP1 | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BQ24 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79038 | ZFYVE21 | LZE3D | Human | Esophagus | HGIN | 2.99e-04 | 5.89e-01 | 0.0668 |
79038 | ZFYVE21 | LZE4T | Human | Esophagus | ESCC | 5.02e-12 | 1.95e-01 | 0.0811 |
79038 | ZFYVE21 | LZE5T | Human | Esophagus | ESCC | 7.22e-06 | 3.62e-01 | 0.0514 |
79038 | ZFYVE21 | LZE8T | Human | Esophagus | ESCC | 7.64e-07 | 1.81e-01 | 0.067 |
79038 | ZFYVE21 | LZE20T | Human | Esophagus | ESCC | 1.59e-14 | 6.45e-01 | 0.0662 |
79038 | ZFYVE21 | LZE22D1 | Human | Esophagus | HGIN | 7.99e-04 | 1.67e-01 | 0.0595 |
79038 | ZFYVE21 | LZE22T | Human | Esophagus | ESCC | 1.55e-06 | 6.60e-01 | 0.068 |
79038 | ZFYVE21 | LZE24T | Human | Esophagus | ESCC | 1.08e-25 | 7.13e-01 | 0.0596 |
79038 | ZFYVE21 | LZE6T | Human | Esophagus | ESCC | 9.08e-04 | 8.98e-02 | 0.0845 |
79038 | ZFYVE21 | P1T-E | Human | Esophagus | ESCC | 7.38e-03 | 4.09e-01 | 0.0875 |
79038 | ZFYVE21 | P2T-E | Human | Esophagus | ESCC | 1.87e-22 | 3.63e-01 | 0.1177 |
79038 | ZFYVE21 | P4T-E | Human | Esophagus | ESCC | 1.08e-36 | 8.16e-01 | 0.1323 |
79038 | ZFYVE21 | P5T-E | Human | Esophagus | ESCC | 6.60e-30 | 7.18e-01 | 0.1327 |
79038 | ZFYVE21 | P8T-E | Human | Esophagus | ESCC | 4.54e-49 | 7.97e-01 | 0.0889 |
79038 | ZFYVE21 | P9T-E | Human | Esophagus | ESCC | 6.72e-14 | 3.03e-01 | 0.1131 |
79038 | ZFYVE21 | P10T-E | Human | Esophagus | ESCC | 1.51e-91 | 1.78e+00 | 0.116 |
79038 | ZFYVE21 | P11T-E | Human | Esophagus | ESCC | 6.51e-25 | 5.91e-01 | 0.1426 |
79038 | ZFYVE21 | P12T-E | Human | Esophagus | ESCC | 8.63e-60 | 1.21e+00 | 0.1122 |
79038 | ZFYVE21 | P15T-E | Human | Esophagus | ESCC | 2.92e-54 | 1.19e+00 | 0.1149 |
79038 | ZFYVE21 | P16T-E | Human | Esophagus | ESCC | 6.95e-29 | 6.29e-01 | 0.1153 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFYVE21 | insertion | Frame_Shift_Ins | novel | c.283_284insGTCCTAAGCAGTGGGACTTGGGT | p.Gln95ArgfsTer32 | p.Q95Rfs*32 | Q9BQ24 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
ZFYVE21 | SNV | Missense_Mutation | novel | c.532N>C | p.Asp178His | p.D178H | Q9BQ24 | protein_coding | tolerated(0.09) | benign(0.139) | TCGA-VS-A9V2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZFYVE21 | SNV | Missense_Mutation | c.505A>G | p.Thr169Ala | p.T169A | Q9BQ24 | protein_coding | tolerated(0.14) | benign(0.013) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZFYVE21 | SNV | Missense_Mutation | rs746354819 | c.277N>A | p.Val93Met | p.V93M | Q9BQ24 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZFYVE21 | SNV | Missense_Mutation | rs148406990 | c.458N>A | p.Ser153Asn | p.S153N | Q9BQ24 | protein_coding | tolerated(0.06) | benign(0.073) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZFYVE21 | SNV | Missense_Mutation | rs758059451 | c.640G>A | p.Val214Met | p.V214M | Q9BQ24 | protein_coding | tolerated(0.22) | benign(0.021) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFYVE21 | SNV | Missense_Mutation | rs374319040 | c.593N>A | p.Arg198Gln | p.R198Q | Q9BQ24 | protein_coding | tolerated(0.09) | probably_damaging(0.942) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFYVE21 | SNV | Missense_Mutation | novel | c.736N>A | p.Leu246Ile | p.L246I | Q9BQ24 | protein_coding | tolerated(0.18) | probably_damaging(0.925) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
ZFYVE21 | SNV | Missense_Mutation | novel | c.551N>A | p.Ser184Asn | p.S184N | Q9BQ24 | protein_coding | tolerated(0.13) | possibly_damaging(0.603) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ZFYVE21 | SNV | Missense_Mutation | novel | c.401N>G | p.Glu134Gly | p.E134G | Q9BQ24 | protein_coding | tolerated(0.09) | possibly_damaging(0.468) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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