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Gene: ZFP30 |
Gene summary for ZFP30 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZFP30 | Gene ID | 22835 |
Gene name | ZFP30 zinc finger protein | |
Gene Alias | ZNF745 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | D3Y2A0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22835 | ZFP30 | HCC1_Meng | Human | Liver | HCC | 2.38e-06 | -2.04e-02 | 0.0246 |
22835 | ZFP30 | HCC1 | Human | Liver | HCC | 5.47e-05 | 1.24e+00 | 0.5336 |
22835 | ZFP30 | HCC2 | Human | Liver | HCC | 2.54e-14 | 1.38e+00 | 0.5341 |
22835 | ZFP30 | HCC5 | Human | Liver | HCC | 8.99e-05 | 6.51e-01 | 0.4932 |
22835 | ZFP30 | PTC04 | Human | Thyroid | PTC | 2.55e-04 | 7.71e-02 | 0.1927 |
22835 | ZFP30 | PTC07 | Human | Thyroid | PTC | 1.14e-04 | 8.79e-02 | 0.2044 |
22835 | ZFP30 | ATC13 | Human | Thyroid | ATC | 5.21e-73 | 1.15e+00 | 0.34 |
22835 | ZFP30 | ATC5 | Human | Thyroid | ATC | 7.69e-78 | 1.24e+00 | 0.34 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFP30 | SNV | Missense_Mutation | c.1102N>G | p.His368Asp | p.H368D | Q9Y2G7 | protein_coding | tolerated(0.14) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZFP30 | SNV | Missense_Mutation | novel | c.1491G>C | p.Lys497Asn | p.K497N | Q9Y2G7 | protein_coding | tolerated(0.21) | possibly_damaging(0.745) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
ZFP30 | SNV | Missense_Mutation | c.433N>G | p.Leu145Val | p.L145V | Q9Y2G7 | protein_coding | tolerated(0.09) | benign(0) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
ZFP30 | SNV | Missense_Mutation | rs370737195 | c.1013G>A | p.Arg338Gln | p.R338Q | Q9Y2G7 | protein_coding | tolerated(0.33) | probably_damaging(0.987) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ZFP30 | SNV | Missense_Mutation | rs769698824 | c.967N>A | p.Glu323Lys | p.E323K | Q9Y2G7 | protein_coding | tolerated(0.09) | probably_damaging(0.996) | TCGA-AR-A1AV-01 | Breast | breast invasive carcinoma | Male | >=65 | I/II | Chemotherapy | cytoxan | SD |
ZFP30 | SNV | Missense_Mutation | c.294N>T | p.Met98Ile | p.M98I | Q9Y2G7 | protein_coding | tolerated(1) | benign(0) | TCGA-B6-A400-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
ZFP30 | SNV | Missense_Mutation | c.1089C>A | p.Phe363Leu | p.F363L | Q9Y2G7 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-GM-A2DH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR | |
ZFP30 | insertion | Nonsense_Mutation | novel | c.1266_1267insACATGCTGAATGAC | p.Ser423ThrfsTer3 | p.S423Tfs*3 | Q9Y2G7 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
ZFP30 | insertion | Nonsense_Mutation | novel | c.1036_1037insATAATTATTAAGTTACATTAT | p.Arg346delinsAsnAsnTyrTerValThrLeuTer | p.R346delinsNNY*VTL* | Q9Y2G7 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZFP30 | SNV | Missense_Mutation | rs144294637 | c.1541N>A | p.Arg514Gln | p.R514Q | Q9Y2G7 | protein_coding | deleterious(0.03) | benign(0.158) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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