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Gene: ZFP14 |
Gene summary for ZFP14 |
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Gene information | Species | Human | Gene symbol | ZFP14 | Gene ID | 57677 |
Gene name | ZFP14 zinc finger protein | |
Gene Alias | ZNF531 | |
Cytomap | 19q13.12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9HCL3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57677 | ZFP14 | HCC1_Meng | Human | Liver | HCC | 3.92e-37 | -4.37e-02 | 0.0246 |
57677 | ZFP14 | HCC2_Meng | Human | Liver | HCC | 1.04e-05 | -1.57e-02 | 0.0107 |
57677 | ZFP14 | cirrhotic1 | Human | Liver | Cirrhotic | 6.04e-04 | 1.15e-01 | 0.0202 |
57677 | ZFP14 | HCC1 | Human | Liver | HCC | 7.86e-19 | 2.93e+00 | 0.5336 |
57677 | ZFP14 | HCC2 | Human | Liver | HCC | 1.36e-25 | 2.39e+00 | 0.5341 |
57677 | ZFP14 | HCC5 | Human | Liver | HCC | 2.13e-16 | 1.92e+00 | 0.4932 |
57677 | ZFP14 | male-WTA | Human | Thyroid | PTC | 3.17e-03 | 8.66e-02 | 0.1037 |
57677 | ZFP14 | PTC01 | Human | Thyroid | PTC | 1.26e-06 | 1.58e-01 | 0.1899 |
57677 | ZFP14 | PTC04 | Human | Thyroid | PTC | 1.49e-07 | 1.48e-01 | 0.1927 |
57677 | ZFP14 | PTC05 | Human | Thyroid | PTC | 6.20e-13 | 4.66e-01 | 0.2065 |
57677 | ZFP14 | PTC06 | Human | Thyroid | PTC | 3.59e-18 | 3.74e-01 | 0.2057 |
57677 | ZFP14 | PTC07 | Human | Thyroid | PTC | 1.31e-19 | 3.08e-01 | 0.2044 |
57677 | ZFP14 | ATC12 | Human | Thyroid | ATC | 1.45e-02 | 1.19e-01 | 0.34 |
57677 | ZFP14 | ATC13 | Human | Thyroid | ATC | 2.12e-43 | 7.29e-01 | 0.34 |
57677 | ZFP14 | ATC1 | Human | Thyroid | ATC | 4.00e-02 | 1.41e-01 | 0.2878 |
57677 | ZFP14 | ATC4 | Human | Thyroid | ATC | 3.04e-06 | 1.62e-01 | 0.34 |
57677 | ZFP14 | ATC5 | Human | Thyroid | ATC | 9.23e-50 | 7.60e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZFP14 | BAS | Oral cavity | NEOLP | RARB,LOXL1,PRR16, etc. | 0.00e+00 | ![]() |
ZFP14 | GRA | Oral cavity | NEOLP | RARB,LOXL1,PRR16, etc. | 0.00e+00 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFP14 | SNV | Missense_Mutation | novel | c.925N>A | p.Glu309Lys | p.E309K | Q9HCL3 | protein_coding | tolerated(0.17) | possibly_damaging(0.892) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP14 | SNV | Missense_Mutation | rs545462128 | c.1245N>C | p.Gln415His | p.Q415H | Q9HCL3 | protein_coding | deleterious(0.04) | benign(0.052) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZFP14 | SNV | Missense_Mutation | c.450N>A | p.Met150Ile | p.M150I | Q9HCL3 | protein_coding | tolerated(0.38) | benign(0) | TCGA-D8-A1XM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZFP14 | deletion | Frame_Shift_Del | c.10_16delNNNNNNN | p.Gly4Ter | p.G4* | Q9HCL3 | protein_coding | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
ZFP14 | SNV | Missense_Mutation | novel | c.205G>A | p.Val69Met | p.V69M | Q9HCL3 | protein_coding | tolerated(0.31) | benign(0.012) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZFP14 | SNV | Missense_Mutation | rs768243359 | c.650N>A | p.Arg217Gln | p.R217Q | Q9HCL3 | protein_coding | tolerated(0.94) | benign(0.341) | TCGA-HM-A3JJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ZFP14 | SNV | Missense_Mutation | c.1499G>A | p.Arg500Lys | p.R500K | Q9HCL3 | protein_coding | tolerated(0.19) | benign(0.199) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZFP14 | SNV | Missense_Mutation | c.1203T>G | p.Cys401Trp | p.C401W | Q9HCL3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZFP14 | SNV | Missense_Mutation | rs571512137 | c.1153C>T | p.Arg385Cys | p.R385C | Q9HCL3 | protein_coding | deleterious(0.03) | probably_damaging(0.923) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ZFP14 | SNV | Missense_Mutation | c.1501A>T | p.Ile501Phe | p.I501F | Q9HCL3 | protein_coding | deleterious(0.02) | probably_damaging(0.959) | TCGA-AU-3779-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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