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Gene: ZFAS1 |
Gene summary for ZFAS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZFAS1 | Gene ID | 441951 |
Gene name | ZNFX1 antisense RNA 1 | |
Gene Alias | C20orf199 | |
Cytomap | 20q13.13 | |
Gene Type | ncRNA | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
441951 | ZFAS1 | GSM4909281 | Human | Breast | IDC | 1.10e-32 | -5.04e-01 | 0.21 |
441951 | ZFAS1 | GSM4909282 | Human | Breast | IDC | 1.28e-42 | -6.17e-01 | -0.0288 |
441951 | ZFAS1 | GSM4909286 | Human | Breast | IDC | 1.69e-03 | -1.01e-01 | 0.1081 |
441951 | ZFAS1 | GSM4909287 | Human | Breast | IDC | 2.94e-18 | -4.85e-01 | 0.2057 |
441951 | ZFAS1 | GSM4909288 | Human | Breast | IDC | 6.53e-13 | -7.26e-01 | 0.0988 |
441951 | ZFAS1 | GSM4909290 | Human | Breast | IDC | 2.54e-35 | -6.89e-01 | 0.2096 |
441951 | ZFAS1 | GSM4909291 | Human | Breast | IDC | 2.97e-14 | -4.74e-01 | 0.1753 |
441951 | ZFAS1 | GSM4909294 | Human | Breast | IDC | 3.51e-19 | -4.92e-01 | 0.2022 |
441951 | ZFAS1 | GSM4909296 | Human | Breast | IDC | 4.45e-06 | 1.10e-02 | 0.1524 |
441951 | ZFAS1 | GSM4909297 | Human | Breast | IDC | 1.19e-25 | -1.66e-01 | 0.1517 |
441951 | ZFAS1 | GSM4909301 | Human | Breast | IDC | 1.26e-03 | 1.10e-01 | 0.1577 |
441951 | ZFAS1 | GSM4909302 | Human | Breast | IDC | 1.45e-02 | -1.10e-01 | 0.1545 |
441951 | ZFAS1 | GSM4909306 | Human | Breast | IDC | 6.10e-03 | -1.73e-01 | 0.1564 |
441951 | ZFAS1 | GSM4909308 | Human | Breast | IDC | 1.57e-32 | -5.03e-01 | 0.158 |
441951 | ZFAS1 | GSM4909309 | Human | Breast | IDC | 9.18e-07 | 3.97e-02 | 0.0483 |
441951 | ZFAS1 | GSM4909311 | Human | Breast | IDC | 1.88e-47 | -4.22e-01 | 0.1534 |
441951 | ZFAS1 | GSM4909312 | Human | Breast | IDC | 8.81e-19 | -4.85e-01 | 0.1552 |
441951 | ZFAS1 | GSM4909313 | Human | Breast | IDC | 1.06e-11 | -4.06e-01 | 0.0391 |
441951 | ZFAS1 | GSM4909315 | Human | Breast | IDC | 3.52e-06 | -1.52e-01 | 0.21 |
441951 | ZFAS1 | GSM4909316 | Human | Breast | IDC | 1.59e-06 | -4.88e-01 | 0.21 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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