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Gene: ZDHHC14 |
Gene summary for ZDHHC14 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZDHHC14 | Gene ID | 79683 |
| Gene name | zinc finger DHHC-type palmitoyltransferase 14 | |
| Gene Alias | NEW1CP | |
| Cytomap | 6q25.3 | |
| Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8IZN3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 79683 | ZDHHC14 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.91e-03 | 4.73e-01 | -0.0811 |
| 79683 | ZDHHC14 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.40e-10 | 6.10e-01 | -0.1954 |
| 79683 | ZDHHC14 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.48e-07 | 8.21e-01 | -0.059 |
| 79683 | ZDHHC14 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.42e-04 | -2.62e-01 | 0.294 |
| 79683 | ZDHHC14 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.63e-03 | 4.59e-01 | 0.281 |
| 79683 | ZDHHC14 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.59e-07 | -3.32e-01 | 0.3005 |
| 79683 | ZDHHC14 | A015-C-203 | Human | Colorectum | FAP | 4.82e-19 | -3.88e-01 | -0.1294 |
| 79683 | ZDHHC14 | A014-C-040 | Human | Colorectum | FAP | 3.58e-02 | -4.75e-01 | -0.1184 |
| 79683 | ZDHHC14 | A002-C-201 | Human | Colorectum | FAP | 4.06e-04 | -2.21e-01 | 0.0324 |
| 79683 | ZDHHC14 | A001-C-119 | Human | Colorectum | FAP | 9.96e-03 | -3.51e-01 | -0.1557 |
| 79683 | ZDHHC14 | A001-C-108 | Human | Colorectum | FAP | 3.88e-14 | -3.88e-01 | -0.0272 |
| 79683 | ZDHHC14 | A002-C-205 | Human | Colorectum | FAP | 2.80e-09 | -3.07e-01 | -0.1236 |
| 79683 | ZDHHC14 | A001-C-104 | Human | Colorectum | FAP | 1.51e-04 | -2.89e-01 | 0.0184 |
| 79683 | ZDHHC14 | A015-C-006 | Human | Colorectum | FAP | 1.49e-04 | -2.75e-01 | -0.0994 |
| 79683 | ZDHHC14 | A015-C-106 | Human | Colorectum | FAP | 4.33e-09 | -3.26e-01 | -0.0511 |
| 79683 | ZDHHC14 | A002-C-114 | Human | Colorectum | FAP | 1.35e-07 | -3.22e-01 | -0.1561 |
| 79683 | ZDHHC14 | A015-C-104 | Human | Colorectum | FAP | 1.04e-18 | -4.02e-01 | -0.1899 |
| 79683 | ZDHHC14 | A001-C-014 | Human | Colorectum | FAP | 7.20e-09 | -3.38e-01 | 0.0135 |
| 79683 | ZDHHC14 | A002-C-016 | Human | Colorectum | FAP | 9.19e-14 | -3.03e-01 | 0.0521 |
| 79683 | ZDHHC14 | A015-C-002 | Human | Colorectum | FAP | 1.10e-06 | -4.46e-01 | -0.0763 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
| GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
| GO:00901502 | Colorectum | MSS | establishment of protein localization to membrane | 90/3467 | 260/18723 | 4.11e-10 | 3.49e-08 | 90 |
| GO:00066052 | Colorectum | MSS | protein targeting | 97/3467 | 314/18723 | 6.76e-08 | 3.46e-06 | 97 |
| GO:00901504 | Colorectum | FAP | establishment of protein localization to membrane | 69/2622 | 260/18723 | 6.40e-08 | 4.54e-06 | 69 |
| GO:00066054 | Colorectum | FAP | protein targeting | 74/2622 | 314/18723 | 3.21e-06 | 1.17e-04 | 74 |
| GO:0006612 | Colorectum | FAP | protein targeting to membrane | 30/2622 | 131/18723 | 3.95e-03 | 2.75e-02 | 30 |
| GO:00901505 | Colorectum | CRC | establishment of protein localization to membrane | 51/2078 | 260/18723 | 3.59e-05 | 9.05e-04 | 51 |
| GO:00066055 | Colorectum | CRC | protein targeting | 54/2078 | 314/18723 | 7.17e-04 | 9.28e-03 | 54 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZDHHC14 | SNV | Missense_Mutation | novel | c.866N>A | p.Ser289Tyr | p.S289Y | Q8IZN3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
| ZDHHC14 | SNV | Missense_Mutation | c.234N>G | p.Phe78Leu | p.F78L | Q8IZN3 | protein_coding | deleterious(0.05) | possibly_damaging(0.562) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ZDHHC14 | SNV | Missense_Mutation | c.695N>G | p.Val232Gly | p.V232G | Q8IZN3 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ZDHHC14 | SNV | Missense_Mutation | novel | c.941C>T | p.Ala314Val | p.A314V | Q8IZN3 | protein_coding | tolerated(1) | benign(0.034) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZDHHC14 | SNV | Missense_Mutation | c.734T>A | p.Leu245His | p.L245H | Q8IZN3 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-AA-3975-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| ZDHHC14 | SNV | Missense_Mutation | rs373622179 | c.388N>A | p.Asp130Asn | p.D130N | Q8IZN3 | protein_coding | tolerated(0.24) | probably_damaging(0.971) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| ZDHHC14 | SNV | Missense_Mutation | rs537154606 | c.796G>A | p.Val266Ile | p.V266I | Q8IZN3 | protein_coding | tolerated(0.23) | benign(0.251) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZDHHC14 | SNV | Missense_Mutation | c.1150N>A | p.Leu384Ile | p.L384I | Q8IZN3 | protein_coding | tolerated(0.78) | benign(0) | TCGA-F4-6569-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
| ZDHHC14 | deletion | Frame_Shift_Del | c.430delN | p.Tyr146ThrfsTer17 | p.Y146Tfs*17 | Q8IZN3 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| ZDHHC14 | SNV | Missense_Mutation | novel | c.130N>T | p.Pro44Ser | p.P44S | Q8IZN3 | protein_coding | deleterious(0.01) | probably_damaging(0.916) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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