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Gene: ZCCHC14 |
Gene summary for ZCCHC14 |
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Gene information | Species | Human | Gene symbol | ZCCHC14 | Gene ID | 23174 |
Gene name | zinc finger CCHC-type containing 14 | |
Gene Alias | BDG-29 | |
Cytomap | 16q24.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8WYQ9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23174 | ZCCHC14 | NAFLD1 | Human | Liver | NAFLD | 6.05e-04 | 5.23e-01 | -0.04 |
23174 | ZCCHC14 | HCC1_Meng | Human | Liver | HCC | 1.08e-21 | -9.04e-02 | 0.0246 |
23174 | ZCCHC14 | HCC2_Meng | Human | Liver | HCC | 7.04e-08 | -6.03e-02 | 0.0107 |
23174 | ZCCHC14 | HCC2 | Human | Liver | HCC | 1.37e-09 | 2.14e+00 | 0.5341 |
23174 | ZCCHC14 | S014 | Human | Liver | HCC | 2.39e-02 | 2.98e-01 | 0.2254 |
23174 | ZCCHC14 | S028 | Human | Liver | HCC | 1.05e-06 | 4.26e-01 | 0.2503 |
23174 | ZCCHC14 | S029 | Human | Liver | HCC | 3.68e-05 | 4.53e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZCCHC14 | SNV | Missense_Mutation | c.355N>C | p.Glu119Gln | p.E119Q | Q8WYQ9 | protein_coding | deleterious(0.03) | benign(0.067) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZCCHC14 | SNV | Missense_Mutation | novel | c.1611N>T | p.Glu537Asp | p.E537D | Q8WYQ9 | protein_coding | tolerated(0.18) | probably_damaging(0.97) | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD |
ZCCHC14 | SNV | Missense_Mutation | c.1946N>T | p.Ser649Phe | p.S649F | Q8WYQ9 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.687) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ZCCHC14 | SNV | Missense_Mutation | rs200914568 | c.1662N>A | p.Ser554Arg | p.S554R | Q8WYQ9 | protein_coding | tolerated_low_confidence(0.37) | benign(0.302) | TCGA-LD-A7W5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
ZCCHC14 | SNV | Missense_Mutation | novel | c.2836G>T | p.Asp946Tyr | p.D946Y | Q8WYQ9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZCCHC14 | SNV | Missense_Mutation | novel | c.2123C>T | p.Ser708Phe | p.S708F | Q8WYQ9 | protein_coding | deleterious(0.01) | possibly_damaging(0.726) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
ZCCHC14 | SNV | Missense_Mutation | novel | c.1237N>A | p.Glu413Lys | p.E413K | Q8WYQ9 | protein_coding | deleterious(0.02) | possibly_damaging(0.473) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ZCCHC14 | SNV | Missense_Mutation | rs768501763 | c.2438C>T | p.Pro813Leu | p.P813L | Q8WYQ9 | protein_coding | tolerated(0.07) | benign(0.024) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZCCHC14 | SNV | Missense_Mutation | rs138569077 | c.1846N>A | p.Val616Met | p.V616M | Q8WYQ9 | protein_coding | deleterious(0.01) | possibly_damaging(0.65) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZCCHC14 | SNV | Missense_Mutation | c.1309G>A | p.Asp437Asn | p.D437N | Q8WYQ9 | protein_coding | deleterious(0.02) | possibly_damaging(0.646) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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