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Gene: ZCCHC11 |
Gene summary for ZCCHC11 |
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Gene information | Species | Human | Gene symbol | ZCCHC11 | Gene ID | 23318 |
Gene name | terminal uridylyl transferase 4 | |
Gene Alias | PAPD3 | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A0C4DFM7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23318 | ZCCHC11 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.37e-60 | 9.74e-01 | 0.294 |
23318 | ZCCHC11 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.40e-05 | 5.85e-01 | 0.3487 |
23318 | ZCCHC11 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.70e-37 | 9.55e-01 | 0.281 |
23318 | ZCCHC11 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.21e-31 | 6.05e-01 | 0.3859 |
23318 | ZCCHC11 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.98e-12 | 4.59e-01 | 0.2585 |
23318 | ZCCHC11 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.17e-24 | 4.69e-01 | 0.3005 |
23318 | ZCCHC11 | AEH-subject1 | Human | Endometrium | AEH | 9.94e-37 | -5.12e-01 | -0.3059 |
23318 | ZCCHC11 | AEH-subject2 | Human | Endometrium | AEH | 6.66e-27 | -5.12e-01 | -0.2525 |
23318 | ZCCHC11 | AEH-subject3 | Human | Endometrium | AEH | 1.75e-35 | -5.12e-01 | -0.2576 |
23318 | ZCCHC11 | AEH-subject4 | Human | Endometrium | AEH | 9.50e-21 | -5.12e-01 | -0.2657 |
23318 | ZCCHC11 | AEH-subject5 | Human | Endometrium | AEH | 1.75e-35 | -5.12e-01 | -0.2953 |
23318 | ZCCHC11 | EEC-subject1 | Human | Endometrium | EEC | 5.49e-38 | -5.12e-01 | -0.2682 |
23318 | ZCCHC11 | EEC-subject2 | Human | Endometrium | EEC | 2.08e-38 | -5.12e-01 | -0.2607 |
23318 | ZCCHC11 | EEC-subject3 | Human | Endometrium | EEC | 1.10e-39 | -5.12e-01 | -0.2525 |
23318 | ZCCHC11 | EEC-subject4 | Human | Endometrium | EEC | 5.49e-38 | -5.12e-01 | -0.2571 |
23318 | ZCCHC11 | EEC-subject5 | Human | Endometrium | EEC | 2.08e-38 | -5.12e-01 | -0.249 |
23318 | ZCCHC11 | GSM5276934 | Human | Endometrium | EEC | 2.08e-38 | -5.12e-01 | -0.0913 |
23318 | ZCCHC11 | GSM5276935 | Human | Endometrium | EEC | 2.08e-38 | -5.12e-01 | -0.123 |
23318 | ZCCHC11 | GSM5276937 | Human | Endometrium | EEC | 2.76e-25 | -5.12e-01 | -0.0897 |
23318 | ZCCHC11 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.94e-22 | -5.12e-01 | -0.1869 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZCCHC11 | SNV | Missense_Mutation | c.3248G>T | p.Arg1083Ile | p.R1083I | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZCCHC11 | SNV | Missense_Mutation | c.4724N>A | p.Arg1575Gln | p.R1575Q | protein_coding | tolerated_low_confidence(0.81) | benign(0.003) | TCGA-AQ-A0Y5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | SD | ||
ZCCHC11 | SNV | Missense_Mutation | c.1348C>A | p.His450Asn | p.H450N | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
ZCCHC11 | SNV | Missense_Mutation | c.2245N>G | p.Leu749Val | p.L749V | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | ||
ZCCHC11 | SNV | Missense_Mutation | c.635N>T | p.Ser212Phe | p.S212F | protein_coding | tolerated_low_confidence(0.09) | possibly_damaging(0.462) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | ||
ZCCHC11 | SNV | Missense_Mutation | c.136G>A | p.Glu46Lys | p.E46K | protein_coding | deleterious_low_confidence(0.02) | benign(0.1) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
ZCCHC11 | SNV | Missense_Mutation | c.4195N>G | p.Gln1399Glu | p.Q1399E | protein_coding | deleterious(0.01) | possibly_damaging(0.646) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
ZCCHC11 | SNV | Missense_Mutation | novel | c.1727G>A | p.Ser576Asn | p.S576N | protein_coding | tolerated(0.51) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZCCHC11 | SNV | Missense_Mutation | c.4720N>G | p.Phe1574Val | p.F1574V | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.692) | TCGA-EA-A1QT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZCCHC11 | SNV | Missense_Mutation | novel | c.387A>C | p.Glu129Asp | p.E129D | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.997) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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