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Gene: ZCCHC10 |
Gene summary for ZCCHC10 |
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Gene information | Species | Human | Gene symbol | ZCCHC10 | Gene ID | 54819 |
Gene name | zinc finger CCHC-type containing 10 | |
Gene Alias | ZCCHC10 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | B4DU89 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54819 | ZCCHC10 | LZE4T | Human | Esophagus | ESCC | 8.13e-14 | 1.50e-01 | 0.0811 |
54819 | ZCCHC10 | LZE8T | Human | Esophagus | ESCC | 1.28e-04 | 1.30e-01 | 0.067 |
54819 | ZCCHC10 | LZE20T | Human | Esophagus | ESCC | 1.60e-06 | 1.05e-01 | 0.0662 |
54819 | ZCCHC10 | LZE22T | Human | Esophagus | ESCC | 4.10e-04 | 4.31e-01 | 0.068 |
54819 | ZCCHC10 | LZE24T | Human | Esophagus | ESCC | 2.79e-11 | 2.74e-01 | 0.0596 |
54819 | ZCCHC10 | P1T-E | Human | Esophagus | ESCC | 3.09e-04 | 1.54e-01 | 0.0875 |
54819 | ZCCHC10 | P2T-E | Human | Esophagus | ESCC | 6.87e-21 | 2.94e-01 | 0.1177 |
54819 | ZCCHC10 | P4T-E | Human | Esophagus | ESCC | 6.19e-20 | 3.05e-01 | 0.1323 |
54819 | ZCCHC10 | P5T-E | Human | Esophagus | ESCC | 5.08e-17 | 3.11e-01 | 0.1327 |
54819 | ZCCHC10 | P8T-E | Human | Esophagus | ESCC | 3.55e-11 | 1.91e-01 | 0.0889 |
54819 | ZCCHC10 | P9T-E | Human | Esophagus | ESCC | 3.86e-24 | 2.86e-01 | 0.1131 |
54819 | ZCCHC10 | P10T-E | Human | Esophagus | ESCC | 1.62e-10 | 1.42e-01 | 0.116 |
54819 | ZCCHC10 | P11T-E | Human | Esophagus | ESCC | 4.35e-06 | 7.51e-02 | 0.1426 |
54819 | ZCCHC10 | P12T-E | Human | Esophagus | ESCC | 3.43e-19 | 2.59e-01 | 0.1122 |
54819 | ZCCHC10 | P15T-E | Human | Esophagus | ESCC | 6.14e-18 | 3.00e-01 | 0.1149 |
54819 | ZCCHC10 | P16T-E | Human | Esophagus | ESCC | 6.37e-19 | 1.14e-01 | 0.1153 |
54819 | ZCCHC10 | P17T-E | Human | Esophagus | ESCC | 1.43e-07 | 1.82e-01 | 0.1278 |
54819 | ZCCHC10 | P19T-E | Human | Esophagus | ESCC | 8.71e-08 | 2.29e-01 | 0.1662 |
54819 | ZCCHC10 | P20T-E | Human | Esophagus | ESCC | 1.59e-16 | 2.56e-01 | 0.1124 |
54819 | ZCCHC10 | P21T-E | Human | Esophagus | ESCC | 2.96e-15 | 2.16e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZCCHC10 | SNV | Missense_Mutation | novel | c.573N>C | p.Lys191Asn | p.K191N | Q8TBK6 | protein_coding | deleterious_low_confidence(0) | benign(0.425) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
ZCCHC10 | SNV | Missense_Mutation | novel | c.511N>G | p.Ser171Gly | p.S171G | Q8TBK6 | protein_coding | tolerated_low_confidence(0.08) | benign(0.003) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZCCHC10 | SNV | Missense_Mutation | rs139067033 | c.388N>G | p.Thr130Ala | p.T130A | Q8TBK6 | protein_coding | deleterious_low_confidence(0.05) | benign(0.021) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZCCHC10 | SNV | Missense_Mutation | novel | c.325N>G | p.Thr109Ala | p.T109A | Q8TBK6 | protein_coding | tolerated_low_confidence(0.05) | probably_damaging(0.956) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZCCHC10 | SNV | Missense_Mutation | novel | c.478T>C | p.Ser160Pro | p.S160P | Q8TBK6 | protein_coding | tolerated_low_confidence(0.49) | probably_damaging(0.979) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZCCHC10 | SNV | Missense_Mutation | novel | c.314N>A | p.Ser105Tyr | p.S105Y | Q8TBK6 | protein_coding | deleterious(0) | possibly_damaging(0.548) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ZCCHC10 | SNV | Missense_Mutation | c.303N>T | p.Lys101Asn | p.K101N | Q8TBK6 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZCCHC10 | deletion | Frame_Shift_Del | c.310delN | p.Arg104GlyfsTer5 | p.R104Gfs*5 | Q8TBK6 | protein_coding | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |||
ZCCHC10 | insertion | Frame_Shift_Ins | novel | c.189_190insA | p.Tyr64IlefsTer4 | p.Y64Ifs*4 | Q8TBK6 | protein_coding | TCGA-B5-A0K6-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZCCHC10 | SNV | Missense_Mutation | c.533A>G | p.Asp178Gly | p.D178G | Q8TBK6 | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-FV-A2QR-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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