Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZC3HAV1

Gene summary for ZC3HAV1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZC3HAV1

Gene ID

56829

Gene namezinc finger CCCH-type containing, antiviral 1
Gene AliasARTD13
Cytomap7q34
Gene Typeprotein-coding
GO ID

GO:0002376

UniProtAcc

Q7Z2W4


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
56829ZC3HAV1HTA11_3410_2000001011HumanColorectumAD2.63e-032.38e-020.0155
56829ZC3HAV1HTA11_347_2000001011HumanColorectumAD1.23e-115.37e-01-0.1954
56829ZC3HAV1A015-C-203HumanColorectumFAP1.53e-12-2.61e-01-0.1294
56829ZC3HAV1A002-C-201HumanColorectumFAP1.63e-02-1.82e-010.0324
56829ZC3HAV1A001-C-108HumanColorectumFAP4.09e-06-2.06e-01-0.0272
56829ZC3HAV1A002-C-205HumanColorectumFAP5.10e-07-2.46e-01-0.1236
56829ZC3HAV1A001-C-104HumanColorectumFAP3.87e-04-1.98e-010.0184
56829ZC3HAV1A015-C-006HumanColorectumFAP9.72e-07-3.49e-01-0.0994
56829ZC3HAV1A015-C-106HumanColorectumFAP1.57e-04-2.37e-01-0.0511
56829ZC3HAV1A002-C-114HumanColorectumFAP1.53e-04-2.11e-01-0.1561
56829ZC3HAV1A015-C-104HumanColorectumFAP7.95e-15-2.87e-01-0.1899
56829ZC3HAV1A001-C-014HumanColorectumFAP1.55e-07-1.97e-010.0135
56829ZC3HAV1A002-C-016HumanColorectumFAP1.26e-08-1.47e-010.0521
56829ZC3HAV1A015-C-002HumanColorectumFAP9.64e-05-3.36e-01-0.0763
56829ZC3HAV1A001-C-203HumanColorectumFAP5.19e-04-1.17e-01-0.0481
56829ZC3HAV1A002-C-116HumanColorectumFAP3.99e-15-2.12e-01-0.0452
56829ZC3HAV1A014-C-008HumanColorectumFAP1.15e-04-2.76e-01-0.191
56829ZC3HAV1A018-E-020HumanColorectumFAP2.09e-05-2.25e-01-0.2034
56829ZC3HAV1F034HumanColorectumFAP3.00e-10-2.04e-01-0.0665
56829ZC3HAV1CRC-3-11773HumanColorectumCRC3.91e-04-1.72e-010.2564
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0016032ColorectumADviral process168/3918415/187234.67e-203.66e-17168
GO:0009896ColorectumADpositive regulation of catabolic process180/3918492/187234.33e-161.94e-13180
GO:1903311ColorectumADregulation of mRNA metabolic process117/3918288/187231.69e-144.23e-12117
GO:0031331ColorectumADpositive regulation of cellular catabolic process156/3918427/187234.68e-141.05e-11156
GO:0019058ColorectumADviral life cycle119/3918317/187236.18e-128.23e-10119
GO:0006401ColorectumADRNA catabolic process102/3918278/187238.64e-106.76e-08102
GO:0044270ColorectumADcellular nitrogen compound catabolic process147/3918451/187233.35e-092.23e-07147
GO:0046700ColorectumADheterocycle catabolic process145/3918445/187234.37e-092.84e-07145
GO:0006402ColorectumADmRNA catabolic process87/3918232/187234.40e-092.84e-0787
GO:0034655ColorectumADnucleobase-containing compound catabolic process133/3918407/187231.56e-089.12e-07133
GO:0019439ColorectumADaromatic compound catabolic process146/3918467/187237.48e-083.84e-06146
GO:1901361ColorectumADorganic cyclic compound catabolic process153/3918495/187238.23e-084.18e-06153
GO:0061013ColorectumADregulation of mRNA catabolic process64/3918166/187231.44e-076.59e-0664
GO:0019079ColorectumADviral genome replication51/3918131/187231.83e-065.51e-0551
GO:0050792ColorectumADregulation of viral process59/3918164/187235.95e-061.52e-0459
GO:1903313ColorectumADpositive regulation of mRNA metabolic process44/3918118/187233.20e-055.87e-0444
GO:1903900ColorectumADregulation of viral life cycle51/3918148/187239.01e-051.38e-0351
GO:0045069ColorectumADregulation of viral genome replication32/391885/187232.97e-043.60e-0332
GO:0061014ColorectumADpositive regulation of mRNA catabolic process32/391887/187234.81e-045.27e-0332
GO:19033114ColorectumFAPregulation of mRNA metabolic process97/2622288/187231.35e-174.13e-1497
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ZC3HAV1SNVMissense_Mutationnovelc.259N>Gp.Leu87Valp.L87VQ7Z2W4protein_codingdeleterious(0.03)probably_damaging(0.991)TCGA-A2-A0CR-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
ZC3HAV1SNVMissense_Mutationnovelc.169G>Ap.Glu57Lysp.E57KQ7Z2W4protein_codingtolerated(0.71)benign(0)TCGA-A7-A4SF-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycarboplatinCR
ZC3HAV1SNVMissense_Mutationrs140539997c.1150G>Ap.Ala384Thrp.A384TQ7Z2W4protein_codingtolerated(0.53)benign(0.001)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZC3HAV1SNVMissense_Mutationrs373894332c.759C>Ap.Phe253Leup.F253LQ7Z2W4protein_codingtolerated(0.75)benign(0.003)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZC3HAV1SNVMissense_Mutationnovelc.2334N>Ap.Met778Ilep.M778IQ7Z2W4protein_codingdeleterious(0.01)benign(0.173)TCGA-C8-A3M7-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownPD
ZC3HAV1SNVMissense_Mutationc.371A>Cp.His124Prop.H124PQ7Z2W4protein_codingdeleterious(0.01)probably_damaging(0.997)TCGA-D8-A1XK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicine+cyclophosphamideSD
ZC3HAV1SNVMissense_Mutationnovelc.803N>Tp.Ala268Valp.A268VQ7Z2W4protein_codingtolerated(0.07)benign(0.006)TCGA-E9-A5UP-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
ZC3HAV1SNVMissense_Mutationc.2178N>Cp.Lys726Asnp.K726NQ7Z2W4protein_codingtolerated(1)benign(0)TCGA-GM-A2D9-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
ZC3HAV1SNVMissense_Mutationnovelc.1171N>Gp.Leu391Valp.L391VQ7Z2W4protein_codingtolerated(0.67)benign(0)TCGA-HN-A2NL-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideSD
ZC3HAV1SNVMissense_Mutationnovelc.2287G>Ap.Glu763Lysp.E763KQ7Z2W4protein_codingtolerated(0.79)benign(0)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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