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Gene: ZC3H12C |
Gene summary for ZC3H12C |
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Gene information | Species | Human | Gene symbol | ZC3H12C | Gene ID | 85463 |
Gene name | zinc finger CCCH-type containing 12C | |
Gene Alias | MCPIP3 | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9C0D7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85463 | ZC3H12C | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.45e-11 | -5.22e-01 | 0.0155 |
85463 | ZC3H12C | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.64e-04 | -3.84e-01 | -0.1808 |
85463 | ZC3H12C | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.83e-02 | -4.71e-01 | -0.1207 |
85463 | ZC3H12C | HTA11_696_2000001011 | Human | Colorectum | AD | 3.63e-03 | -3.28e-01 | -0.1464 |
85463 | ZC3H12C | HTA11_866_3004761011 | Human | Colorectum | AD | 8.24e-06 | -4.79e-01 | 0.096 |
85463 | ZC3H12C | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.77e-03 | -4.77e-01 | 0.0338 |
85463 | ZC3H12C | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.34e-20 | -5.55e-01 | 0.0674 |
85463 | ZC3H12C | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.09e-16 | -5.42e-01 | 0.294 |
85463 | ZC3H12C | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.26e-05 | -5.52e-01 | 0.281 |
85463 | ZC3H12C | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.47e-31 | -6.47e-01 | 0.3859 |
85463 | ZC3H12C | HTA11_99999973899_84307 | Human | Colorectum | MSS | 7.23e-07 | -6.34e-01 | 0.2585 |
85463 | ZC3H12C | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.23e-23 | -6.02e-01 | 0.3005 |
85463 | ZC3H12C | F007 | Human | Colorectum | FAP | 6.02e-06 | -4.96e-01 | 0.1176 |
85463 | ZC3H12C | A002-C-010 | Human | Colorectum | FAP | 3.27e-15 | -4.76e-01 | 0.242 |
85463 | ZC3H12C | A001-C-207 | Human | Colorectum | FAP | 7.05e-08 | -4.60e-01 | 0.1278 |
85463 | ZC3H12C | A015-C-203 | Human | Colorectum | FAP | 7.46e-26 | -4.99e-01 | -0.1294 |
85463 | ZC3H12C | A015-C-204 | Human | Colorectum | FAP | 5.53e-07 | -3.72e-01 | -0.0228 |
85463 | ZC3H12C | A014-C-040 | Human | Colorectum | FAP | 3.12e-04 | -5.61e-01 | -0.1184 |
85463 | ZC3H12C | A002-C-201 | Human | Colorectum | FAP | 1.63e-19 | -5.78e-01 | 0.0324 |
85463 | ZC3H12C | A002-C-203 | Human | Colorectum | FAP | 6.22e-16 | -5.42e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0090501 | Liver | Cirrhotic | RNA phosphodiester bond hydrolysis | 54/4634 | 152/18723 | 1.89e-03 | 1.19e-02 | 54 |
GO:00905011 | Liver | HCC | RNA phosphodiester bond hydrolysis | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:0090502 | Liver | HCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 52/7958 | 82/18723 | 1.06e-04 | 9.08e-04 | 52 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZC3H12C | SNV | Missense_Mutation | rs778003491 | c.2111N>T | p.Pro704Leu | p.P704L | Q9C0D7 | protein_coding | deleterious(0.01) | benign(0.038) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
ZC3H12C | SNV | Missense_Mutation | novel | c.229N>A | p.Glu77Lys | p.E77K | Q9C0D7 | protein_coding | tolerated(0.26) | benign(0.01) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ZC3H12C | SNV | Missense_Mutation | novel | c.2390N>G | p.Asp797Gly | p.D797G | Q9C0D7 | protein_coding | tolerated(0.08) | benign(0.079) | TCGA-A8-A06T-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
ZC3H12C | SNV | Missense_Mutation | c.1954C>T | p.Pro652Ser | p.P652S | Q9C0D7 | protein_coding | tolerated(0.1) | probably_damaging(0.996) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZC3H12C | SNV | Missense_Mutation | novel | c.2543N>C | p.Ile848Thr | p.I848T | Q9C0D7 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
ZC3H12C | SNV | Missense_Mutation | c.2515G>A | p.Glu839Lys | p.E839K | Q9C0D7 | protein_coding | tolerated(0.09) | possibly_damaging(0.76) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZC3H12C | SNV | Missense_Mutation | rs747536263 | c.2308N>T | p.Arg770Cys | p.R770C | Q9C0D7 | protein_coding | tolerated(0.21) | benign(0.306) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZC3H12C | SNV | Missense_Mutation | novel | c.260N>G | p.Ser87Cys | p.S87C | Q9C0D7 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-AQ-A7U7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | rituximab | CR |
ZC3H12C | SNV | Missense_Mutation | novel | c.2390N>T | p.Asp797Val | p.D797V | Q9C0D7 | protein_coding | tolerated(0.06) | benign(0.299) | TCGA-B6-A0IE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZC3H12C | SNV | Missense_Mutation | c.1230N>C | p.Glu410Asp | p.E410D | Q9C0D7 | protein_coding | deleterious(0.03) | possibly_damaging(0.82) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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