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Gene: ZC3H11A |
Gene summary for ZC3H11A |
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Gene information | Species | Human | Gene symbol | ZC3H11A | Gene ID | 9877 |
Gene name | zinc finger CCCH-type containing 11A | |
Gene Alias | ZC3HDC11A | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0006403 | UniProtAcc | O75152 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9877 | ZC3H11A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.83e-02 | 9.99e-02 | 0.0155 |
9877 | ZC3H11A | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.14e-15 | 3.84e-01 | -0.1808 |
9877 | ZC3H11A | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.36e-22 | 5.69e-01 | -0.0811 |
9877 | ZC3H11A | HTA11_78_2000001011 | Human | Colorectum | AD | 6.14e-23 | 5.42e-01 | -0.1088 |
9877 | ZC3H11A | HTA11_347_2000001011 | Human | Colorectum | AD | 3.06e-36 | 5.89e-01 | -0.1954 |
9877 | ZC3H11A | HTA11_411_2000001011 | Human | Colorectum | SER | 2.50e-11 | 5.98e-01 | -0.2602 |
9877 | ZC3H11A | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.90e-09 | 4.77e-01 | -0.2196 |
9877 | ZC3H11A | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.57e-06 | 2.54e-01 | -0.1207 |
9877 | ZC3H11A | HTA11_83_2000001011 | Human | Colorectum | SER | 4.13e-10 | 4.16e-01 | -0.1526 |
9877 | ZC3H11A | HTA11_696_2000001011 | Human | Colorectum | AD | 2.10e-17 | 3.13e-01 | -0.1464 |
9877 | ZC3H11A | HTA11_866_2000001011 | Human | Colorectum | AD | 4.93e-21 | 3.60e-01 | -0.1001 |
9877 | ZC3H11A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.70e-18 | 4.81e-01 | -0.059 |
9877 | ZC3H11A | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.14e-07 | 3.54e-01 | -0.1706 |
9877 | ZC3H11A | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-08 | 2.87e-01 | -0.0842 |
9877 | ZC3H11A | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.36e-06 | 2.32e-01 | -0.0179 |
9877 | ZC3H11A | HTA11_866_3004761011 | Human | Colorectum | AD | 2.43e-14 | 3.06e-01 | 0.096 |
9877 | ZC3H11A | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.84e-10 | 4.88e-01 | 0.0446 |
9877 | ZC3H11A | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.81e-04 | 2.55e-01 | 0.0131 |
9877 | ZC3H11A | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.21e-08 | 2.97e-01 | -0.0177 |
9877 | ZC3H11A | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.19e-07 | 4.93e-01 | 0.0171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
GO:0051236 | Colorectum | AD | establishment of RNA localization | 58/3918 | 166/18723 | 1.95e-05 | 4.01e-04 | 58 |
GO:0015931 | Colorectum | AD | nucleobase-containing compound transport | 73/3918 | 222/18723 | 2.02e-05 | 4.10e-04 | 73 |
GO:0050657 | Colorectum | AD | nucleic acid transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0050658 | Colorectum | AD | RNA transport | 57/3918 | 163/18723 | 2.22e-05 | 4.39e-04 | 57 |
GO:0051168 | Colorectum | AD | nuclear export | 53/3918 | 154/18723 | 6.89e-05 | 1.11e-03 | 53 |
GO:0051028 | Colorectum | AD | mRNA transport | 42/3918 | 130/18723 | 1.57e-03 | 1.32e-02 | 42 |
GO:00069131 | Colorectum | SER | nucleocytoplasmic transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00511691 | Colorectum | SER | nuclear transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00064031 | Colorectum | SER | RNA localization | 53/2897 | 201/18723 | 4.51e-05 | 1.13e-03 | 53 |
GO:00511681 | Colorectum | SER | nuclear export | 42/2897 | 154/18723 | 1.19e-04 | 2.46e-03 | 42 |
GO:00159311 | Colorectum | SER | nucleobase-containing compound transport | 54/2897 | 222/18723 | 3.65e-04 | 5.67e-03 | 54 |
GO:00512361 | Colorectum | SER | establishment of RNA localization | 42/2897 | 166/18723 | 6.70e-04 | 8.96e-03 | 42 |
GO:00506571 | Colorectum | SER | nucleic acid transport | 41/2897 | 163/18723 | 8.74e-04 | 1.06e-02 | 41 |
GO:00506581 | Colorectum | SER | RNA transport | 41/2897 | 163/18723 | 8.74e-04 | 1.06e-02 | 41 |
GO:00069132 | Colorectum | MSS | nucleocytoplasmic transport | 99/3467 | 301/18723 | 1.35e-09 | 1.03e-07 | 99 |
GO:00511692 | Colorectum | MSS | nuclear transport | 99/3467 | 301/18723 | 1.35e-09 | 1.03e-07 | 99 |
GO:00064032 | Colorectum | MSS | RNA localization | 69/3467 | 201/18723 | 6.33e-08 | 3.26e-06 | 69 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZC3H11A | SNV | Missense_Mutation | c.536N>T | p.Thr179Ile | p.T179I | protein_coding | deleterious(0.04) | probably_damaging(0.997) | TCGA-A1-A0SP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |||
ZC3H11A | SNV | Missense_Mutation | c.514G>C | p.Glu172Gln | p.E172Q | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ZC3H11A | SNV | Missense_Mutation | rs772987481 | c.1744C>T | p.Arg582Trp | p.R582W | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZC3H11A | SNV | Missense_Mutation | c.166G>C | p.Glu56Gln | p.E56Q | protein_coding | deleterious(0.01) | possibly_damaging(0.523) | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZC3H11A | SNV | Missense_Mutation | c.1867N>A | p.Glu623Lys | p.E623K | protein_coding | deleterious(0.02) | benign(0.331) | TCGA-AR-A1AS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
ZC3H11A | SNV | Missense_Mutation | novel | c.1013N>T | p.Ser338Leu | p.S338L | protein_coding | tolerated(0.05) | benign(0) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD | |
ZC3H11A | SNV | Missense_Mutation | c.2240C>T | p.Ser747Leu | p.S747L | protein_coding | deleterious(0.05) | probably_damaging(0.988) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | ||
ZC3H11A | SNV | Missense_Mutation | c.65N>A | p.Cys22Tyr | p.C22Y | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A134-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
ZC3H11A | SNV | Missense_Mutation | c.493G>C | p.Asp165His | p.D165H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZC3H11A | SNV | Missense_Mutation | c.22N>C | p.Cys8Arg | p.C8R | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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