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Gene: ZBTB8A |
Gene summary for ZBTB8A |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZBTB8A | Gene ID | 653121 |
Gene name | zinc finger and BTB domain containing 8A | |
Gene Alias | BOZF1 | |
Cytomap | 1p35.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q96BR9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
653121 | ZBTB8A | HCC1 | Human | Liver | HCC | 1.02e-23 | 3.05e+00 | 0.5336 |
653121 | ZBTB8A | HCC2 | Human | Liver | HCC | 4.09e-42 | 3.76e+00 | 0.5341 |
653121 | ZBTB8A | HCC5 | Human | Liver | HCC | 1.44e-59 | 3.31e+00 | 0.4932 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB8A | SNV | Missense_Mutation | c.1220G>A | p.Arg407Lys | p.R407K | Q96BR9 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZBTB8A | insertion | Frame_Shift_Ins | novel | c.314_315insTGCTGGCCTCGAACTCCTGACC | p.Gln106AlafsTer11 | p.Q106Afs*11 | Q96BR9 | protein_coding | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
ZBTB8A | SNV | Missense_Mutation | novel | c.854C>A | p.Pro285Gln | p.P285Q | Q96BR9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZBTB8A | SNV | Missense_Mutation | rs757047444 | c.905N>A | p.Arg302His | p.R302H | Q96BR9 | protein_coding | deleterious(0) | possibly_damaging(0.82) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB8A | SNV | Missense_Mutation | novel | c.482C>A | p.Ser161Tyr | p.S161Y | Q96BR9 | protein_coding | tolerated(0.33) | possibly_damaging(0.694) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZBTB8A | SNV | Missense_Mutation | c.52N>T | p.Arg18Cys | p.R18C | Q96BR9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DC-6158-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB8A | SNV | Missense_Mutation | c.52C>T | p.Arg18Cys | p.R18C | Q96BR9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZBTB8A | SNV | Missense_Mutation | novel | c.1159C>T | p.Leu387Phe | p.L387F | Q96BR9 | protein_coding | tolerated(0.71) | benign(0.029) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB8A | SNV | Missense_Mutation | novel | c.253T>C | p.Ser85Pro | p.S85P | Q96BR9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ZBTB8A | SNV | Missense_Mutation | rs139076803 | c.1081C>T | p.Arg361Cys | p.R361C | Q96BR9 | protein_coding | tolerated(0.06) | possibly_damaging(0.667) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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