Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZBTB5

Gene summary for ZBTB5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZBTB5

Gene ID

9925

Gene namezinc finger and BTB domain containing 5
Gene AliasZBTB5
Cytomap9p13.2
Gene Typeprotein-coding
GO ID

GO:0000122

UniProtAcc

O15062


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
9925ZBTB5LZE4THumanEsophagusESCC9.36e-062.15e-010.0811
9925ZBTB5LZE7THumanEsophagusESCC1.65e-063.14e-010.0667
9925ZBTB5LZE8THumanEsophagusESCC2.65e-041.53e-010.067
9925ZBTB5LZE24THumanEsophagusESCC2.08e-081.48e-010.0596
9925ZBTB5P2T-EHumanEsophagusESCC8.67e-142.61e-010.1177
9925ZBTB5P4T-EHumanEsophagusESCC3.18e-027.18e-020.1323
9925ZBTB5P9T-EHumanEsophagusESCC3.39e-057.12e-020.1131
9925ZBTB5P10T-EHumanEsophagusESCC1.38e-061.22e-010.116
9925ZBTB5P12T-EHumanEsophagusESCC5.35e-121.02e-010.1122
9925ZBTB5P15T-EHumanEsophagusESCC1.59e-041.09e-010.1149
9925ZBTB5P16T-EHumanEsophagusESCC8.69e-046.65e-020.1153
9925ZBTB5P21T-EHumanEsophagusESCC3.47e-043.82e-020.1617
9925ZBTB5P22T-EHumanEsophagusESCC2.16e-033.52e-020.1236
9925ZBTB5P24T-EHumanEsophagusESCC9.27e-034.86e-020.1287
9925ZBTB5P26T-EHumanEsophagusESCC2.61e-051.05e-010.1276
9925ZBTB5P27T-EHumanEsophagusESCC5.07e-057.08e-020.1055
9925ZBTB5P28T-EHumanEsophagusESCC3.11e-225.10e-010.1149
9925ZBTB5P31T-EHumanEsophagusESCC6.31e-084.62e-020.1251
9925ZBTB5P32T-EHumanEsophagusESCC4.22e-098.63e-020.1666
9925ZBTB5P36T-EHumanEsophagusESCC1.26e-061.22e-010.1187
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ZBTB5PERIBreastADJRPS14,NBPF10,RBBP6, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZBTB5ICAFBreastDCISRPS14,NBPF10,RBBP6, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZBTB5LYMENDBreastIDCRPS14,NBPF10,RBBP6, etc.1.19e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZBTB5FIBBreastPrecancerRPS14,NBPF10,RBBP6, etc.1.24e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZBTB5CD8TEREXColorectumMSSDOK3,PER2,FCER2, etc.9.42e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
ZBTB5CD8TCMColorectumSERDOK3,PER2,FCER2, etc.4.72e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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