|
Gene: ZBTB45 |
Gene summary for ZBTB45 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZBTB45 | Gene ID | 84878 |
Gene name | zinc finger and BTB domain containing 45 | |
Gene Alias | ZNF499 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024R4T8 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84878 | ZBTB45 | LZE20T | Human | Esophagus | ESCC | 4.67e-02 | 7.51e-02 | 0.0662 |
84878 | ZBTB45 | LZE24T | Human | Esophagus | ESCC | 3.71e-09 | 1.10e-01 | 0.0596 |
84878 | ZBTB45 | P1T-E | Human | Esophagus | ESCC | 5.90e-03 | 1.32e-01 | 0.0875 |
84878 | ZBTB45 | P2T-E | Human | Esophagus | ESCC | 4.14e-13 | 2.08e-01 | 0.1177 |
84878 | ZBTB45 | P4T-E | Human | Esophagus | ESCC | 2.65e-09 | 1.90e-01 | 0.1323 |
84878 | ZBTB45 | P8T-E | Human | Esophagus | ESCC | 7.69e-20 | 2.90e-01 | 0.0889 |
84878 | ZBTB45 | P9T-E | Human | Esophagus | ESCC | 1.44e-02 | 4.02e-02 | 0.1131 |
84878 | ZBTB45 | P10T-E | Human | Esophagus | ESCC | 6.84e-19 | 2.43e-01 | 0.116 |
84878 | ZBTB45 | P11T-E | Human | Esophagus | ESCC | 2.69e-10 | 3.43e-01 | 0.1426 |
84878 | ZBTB45 | P12T-E | Human | Esophagus | ESCC | 9.44e-09 | 2.37e-01 | 0.1122 |
84878 | ZBTB45 | P15T-E | Human | Esophagus | ESCC | 2.48e-12 | 1.48e-01 | 0.1149 |
84878 | ZBTB45 | P16T-E | Human | Esophagus | ESCC | 2.94e-14 | 1.06e-01 | 0.1153 |
84878 | ZBTB45 | P20T-E | Human | Esophagus | ESCC | 1.32e-04 | 8.17e-02 | 0.1124 |
84878 | ZBTB45 | P21T-E | Human | Esophagus | ESCC | 1.49e-12 | 1.14e-01 | 0.1617 |
84878 | ZBTB45 | P22T-E | Human | Esophagus | ESCC | 5.36e-21 | 1.97e-01 | 0.1236 |
84878 | ZBTB45 | P23T-E | Human | Esophagus | ESCC | 7.31e-10 | 2.51e-01 | 0.108 |
84878 | ZBTB45 | P24T-E | Human | Esophagus | ESCC | 3.88e-08 | 1.72e-01 | 0.1287 |
84878 | ZBTB45 | P26T-E | Human | Esophagus | ESCC | 4.54e-17 | 3.56e-01 | 0.1276 |
84878 | ZBTB45 | P27T-E | Human | Esophagus | ESCC | 1.10e-12 | 1.79e-01 | 0.1055 |
84878 | ZBTB45 | P28T-E | Human | Esophagus | ESCC | 4.66e-09 | 1.27e-01 | 0.1149 |
Page: 1 2 3 |
Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB45 | SNV | Missense_Mutation | c.328N>T | p.Arg110Cys | p.R110C | Q96K62 | protein_coding | deleterious(0) | probably_damaging(0.958) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZBTB45 | SNV | Missense_Mutation | novel | c.316N>A | p.Ala106Thr | p.A106T | Q96K62 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-EA-A3HR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB45 | SNV | Missense_Mutation | c.1277N>T | p.Ser426Leu | p.S426L | Q96K62 | protein_coding | deleterious(0) | possibly_damaging(0.697) | TCGA-IR-A3LB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
ZBTB45 | SNV | Missense_Mutation | rs750055767 | c.530N>T | p.Ala177Val | p.A177V | Q96K62 | protein_coding | tolerated(1) | benign(0.074) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB45 | SNV | Missense_Mutation | rs747624433 | c.118C>T | p.Arg40Cys | p.R40C | Q96K62 | protein_coding | deleterious(0) | benign(0.015) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZBTB45 | SNV | Missense_Mutation | c.1201N>T | p.Pro401Ser | p.P401S | Q96K62 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB45 | SNV | Missense_Mutation | rs778329030 | c.1244N>A | p.Arg415Gln | p.R415Q | Q96K62 | protein_coding | deleterious(0.01) | probably_damaging(0.909) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB45 | SNV | Missense_Mutation | novel | c.1159N>C | p.Ala387Pro | p.A387P | Q96K62 | protein_coding | tolerated(0.15) | possibly_damaging(0.462) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
ZBTB45 | SNV | Missense_Mutation | c.1130T>C | p.Val377Ala | p.V377A | Q96K62 | protein_coding | tolerated(1) | benign(0) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZBTB45 | SNV | Missense_Mutation | novel | c.835N>A | p.Ala279Thr | p.A279T | Q96K62 | protein_coding | tolerated(0.51) | benign(0) | TCGA-AG-4008-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |