|
Gene: ZBTB4 |
Gene summary for ZBTB4 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ZBTB4 | Gene ID | 57659 |
Gene name | zinc finger and BTB domain containing 4 | |
Gene Alias | KAISO-L1 | |
Cytomap | 17p13.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9P1Z0 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57659 | ZBTB4 | LZE7T | Human | Esophagus | ESCC | 9.01e-04 | 3.53e-02 | 0.0667 |
57659 | ZBTB4 | LZE8T | Human | Esophagus | ESCC | 1.36e-09 | 6.99e-02 | 0.067 |
57659 | ZBTB4 | LZE20T | Human | Esophagus | ESCC | 5.96e-05 | 4.34e-04 | 0.0662 |
57659 | ZBTB4 | LZE24T | Human | Esophagus | ESCC | 1.22e-10 | 2.13e-01 | 0.0596 |
57659 | ZBTB4 | LZE21T | Human | Esophagus | ESCC | 2.34e-04 | 1.35e-01 | 0.0655 |
57659 | ZBTB4 | P1T-E | Human | Esophagus | ESCC | 1.63e-02 | 2.06e-01 | 0.0875 |
57659 | ZBTB4 | P2T-E | Human | Esophagus | ESCC | 3.93e-10 | 8.75e-02 | 0.1177 |
57659 | ZBTB4 | P4T-E | Human | Esophagus | ESCC | 6.01e-11 | 9.36e-02 | 0.1323 |
57659 | ZBTB4 | P5T-E | Human | Esophagus | ESCC | 3.51e-05 | -5.14e-02 | 0.1327 |
57659 | ZBTB4 | P8T-E | Human | Esophagus | ESCC | 3.64e-24 | 3.19e-01 | 0.0889 |
57659 | ZBTB4 | P9T-E | Human | Esophagus | ESCC | 8.26e-08 | 6.68e-04 | 0.1131 |
57659 | ZBTB4 | P10T-E | Human | Esophagus | ESCC | 3.91e-21 | 9.14e-02 | 0.116 |
57659 | ZBTB4 | P11T-E | Human | Esophagus | ESCC | 1.08e-06 | 2.08e-01 | 0.1426 |
57659 | ZBTB4 | P12T-E | Human | Esophagus | ESCC | 2.12e-09 | 6.09e-02 | 0.1122 |
57659 | ZBTB4 | P15T-E | Human | Esophagus | ESCC | 1.74e-03 | -7.00e-03 | 0.1149 |
57659 | ZBTB4 | P16T-E | Human | Esophagus | ESCC | 6.34e-20 | 7.31e-02 | 0.1153 |
57659 | ZBTB4 | P17T-E | Human | Esophagus | ESCC | 2.27e-02 | 6.49e-02 | 0.1278 |
57659 | ZBTB4 | P19T-E | Human | Esophagus | ESCC | 9.67e-04 | 2.34e-01 | 0.1662 |
57659 | ZBTB4 | P20T-E | Human | Esophagus | ESCC | 4.53e-13 | 4.23e-02 | 0.1124 |
57659 | ZBTB4 | P21T-E | Human | Esophagus | ESCC | 1.60e-05 | 3.66e-02 | 0.1617 |
Page: 1 2 3 4 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000072319 | Esophagus | ESCC | telomere maintenance | 99/8552 | 131/18723 | 2.68e-12 | 1.08e-10 | 99 |
GO:001083319 | Esophagus | ESCC | telomere maintenance via telomere lengthening | 61/8552 | 81/18723 | 5.24e-08 | 9.37e-07 | 61 |
GO:003220014 | Esophagus | ESCC | telomere organization | 99/8552 | 159/18723 | 1.77e-05 | 1.57e-04 | 99 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB4 | SNV | Missense_Mutation | c.1678N>T | p.Arg560Trp | p.R560W | Q9P1Z0 | protein_coding | deleterious(0) | benign(0.249) | TCGA-AR-A24V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZBTB4 | SNV | Missense_Mutation | novel | c.2505N>A | p.Ser835Arg | p.S835R | Q9P1Z0 | protein_coding | tolerated(0.32) | benign(0.082) | TCGA-BH-A18I-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
ZBTB4 | SNV | Missense_Mutation | c.109G>A | p.Gly37Arg | p.G37R | Q9P1Z0 | protein_coding | tolerated(0.16) | possibly_damaging(0.889) | TCGA-D8-A1XM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZBTB4 | deletion | Frame_Shift_Del | rs765991494 | c.11delC | p.Pro4LeufsTer4 | p.P4Lfs*4 | Q9P1Z0 | protein_coding | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | ||
ZBTB4 | deletion | Frame_Shift_Del | novel | c.2012delN | p.Lys671SerfsTer68 | p.K671Sfs*68 | Q9P1Z0 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZBTB4 | SNV | Missense_Mutation | novel | c.1846N>T | p.Arg616Cys | p.R616C | Q9P1Z0 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZBTB4 | SNV | Missense_Mutation | novel | c.2860N>C | p.Asp954His | p.D954H | Q9P1Z0 | protein_coding | deleterious(0.01) | possibly_damaging(0.887) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ZBTB4 | SNV | Missense_Mutation | c.326N>G | p.Ser109Cys | p.S109C | Q9P1Z0 | protein_coding | tolerated_low_confidence(0.1) | benign(0.003) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
ZBTB4 | SNV | Missense_Mutation | novel | c.2461G>C | p.Glu821Gln | p.E821Q | Q9P1Z0 | protein_coding | tolerated(0.08) | possibly_damaging(0.702) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB4 | SNV | Missense_Mutation | novel | c.541N>A | p.Gly181Arg | p.G181R | Q9P1Z0 | protein_coding | deleterious(0.05) | benign(0.109) | TCGA-5M-AAT4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |