![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZBTB22 |
Gene summary for ZBTB22 |
![]() |
Gene information | Species | Human | Gene symbol | ZBTB22 | Gene ID | 9278 |
Gene name | zinc finger and BTB domain containing 22 | |
Gene Alias | BING1 | |
Cytomap | 6p21.32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A1U9X8V3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9278 | ZBTB22 | C21 | Human | Oral cavity | OSCC | 1.57e-07 | 3.37e-01 | 0.2678 |
9278 | ZBTB22 | C30 | Human | Oral cavity | OSCC | 1.34e-13 | 6.40e-01 | 0.3055 |
9278 | ZBTB22 | C38 | Human | Oral cavity | OSCC | 3.18e-05 | 5.98e-01 | 0.172 |
9278 | ZBTB22 | C46 | Human | Oral cavity | OSCC | 5.81e-03 | 1.74e-01 | 0.1673 |
9278 | ZBTB22 | C08 | Human | Oral cavity | OSCC | 3.95e-06 | 1.35e-01 | 0.1919 |
9278 | ZBTB22 | SYSMH1 | Human | Oral cavity | OSCC | 4.07e-02 | 5.44e-02 | 0.1127 |
9278 | ZBTB22 | SYSMH2 | Human | Oral cavity | OSCC | 7.60e-07 | 1.34e-01 | 0.2326 |
9278 | ZBTB22 | SYSMH3 | Human | Oral cavity | OSCC | 8.10e-07 | 1.17e-01 | 0.2442 |
9278 | ZBTB22 | SYSMH6 | Human | Oral cavity | OSCC | 3.04e-04 | 9.53e-02 | 0.1275 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB22 | SNV | Missense_Mutation | c.667N>A | p.Glu223Lys | p.E223K | O15209 | protein_coding | tolerated(0.65) | benign(0.051) | TCGA-BH-A0E1-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
ZBTB22 | SNV | Missense_Mutation | c.1306N>C | p.Ser436Pro | p.S436P | O15209 | protein_coding | deleterious(0.03) | possibly_damaging(0.624) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB22 | SNV | Missense_Mutation | rs750159071 | c.526N>A | p.Gly176Arg | p.G176R | O15209 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB22 | SNV | Missense_Mutation | c.780N>T | p.Glu260Asp | p.E260D | O15209 | protein_coding | tolerated(0.18) | possibly_damaging(0.675) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
ZBTB22 | SNV | Missense_Mutation | novel | c.1493N>A | p.Ser498Asn | p.S498N | O15209 | protein_coding | deleterious(0.02) | benign(0.088) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB22 | SNV | Missense_Mutation | rs372697719 | c.566N>T | p.Ala189Val | p.A189V | O15209 | protein_coding | tolerated(0.42) | benign(0) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
ZBTB22 | SNV | Missense_Mutation | c.188N>C | p.Val63Ala | p.V63A | O15209 | protein_coding | deleterious(0.02) | possibly_damaging(0.545) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB22 | SNV | Missense_Mutation | rs773438495 | c.568N>T | p.Arg190Cys | p.R190C | O15209 | protein_coding | deleterious(0.05) | probably_damaging(0.985) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
ZBTB22 | SNV | Missense_Mutation | c.1229C>T | p.Ser410Phe | p.S410F | O15209 | protein_coding | deleterious(0.03) | benign(0.029) | TCGA-AG-A02G-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PD | |
ZBTB22 | SNV | Missense_Mutation | novel | c.224N>C | p.Leu75Pro | p.L75P | O15209 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9278 | ZBTB22 | NA | aspirin | ASPIRIN |
Page: 1 |