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Gene: ZBTB18 |
Gene summary for ZBTB18 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ZBTB18 | Gene ID | 10472 |
| Gene name | zinc finger and BTB domain containing 18 | |
| Gene Alias | C2H2-171 | |
| Cytomap | 1q44 | |
| Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q99592 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10472 | ZBTB18 | HCC2_Meng | Human | Liver | HCC | 1.56e-10 | 6.67e-02 | 0.0107 |
| 10472 | ZBTB18 | HCC1 | Human | Liver | HCC | 2.71e-13 | 3.75e+00 | 0.5336 |
| 10472 | ZBTB18 | S014 | Human | Liver | HCC | 7.11e-11 | 5.87e-01 | 0.2254 |
| 10472 | ZBTB18 | S015 | Human | Liver | HCC | 1.09e-03 | 3.17e-01 | 0.2375 |
| 10472 | ZBTB18 | S016 | Human | Liver | HCC | 3.60e-14 | 5.87e-01 | 0.2243 |
| 10472 | ZBTB18 | S028 | Human | Liver | HCC | 9.98e-06 | 3.20e-01 | 0.2503 |
| 10472 | ZBTB18 | S029 | Human | Liver | HCC | 8.50e-06 | 3.52e-01 | 0.2581 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ZBTB18 | NK | Lung | MIAC | ANAPC2,PBRM1,TTC13, etc. | 1.02e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ZBTB18 | SNV | Missense_Mutation | c.512G>C | p.Gly171Ala | p.G171A | Q99592 | protein_coding | tolerated(0.25) | benign(0.031) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| ZBTB18 | SNV | Missense_Mutation | c.985N>T | p.Asp329Tyr | p.D329Y | Q99592 | protein_coding | deleterious(0.04) | possibly_damaging(0.563) | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
| ZBTB18 | insertion | Frame_Shift_Ins | novel | c.1248_1249insTGTGATGAGAGTGATGTTGGCACTAATGACTATGACATGG | p.Asn417CysfsTer97 | p.N417Cfs*97 | Q99592 | protein_coding | TCGA-A7-A0D9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | ||
| ZBTB18 | insertion | Nonsense_Mutation | novel | c.1416_1417insGAGAAGGAAAGGTAAAGGAAAAAAGAGA | p.Lys473GlufsTer5 | p.K473Efs*5 | Q99592 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
| ZBTB18 | SNV | Missense_Mutation | rs17853693 | c.178C>A | p.Leu60Ile | p.L60I | Q99592 | protein_coding | deleterious(0.01) | possibly_damaging(0.835) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| ZBTB18 | SNV | Missense_Mutation | novel | c.418N>A | p.Glu140Lys | p.E140K | Q99592 | protein_coding | deleterious(0.02) | probably_damaging(0.915) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| ZBTB18 | SNV | Missense_Mutation | c.265G>C | p.Glu89Gln | p.E89Q | Q99592 | protein_coding | deleterious(0.03) | probably_damaging(0.941) | TCGA-FU-A2QG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| ZBTB18 | SNV | Missense_Mutation | rs756323931 | c.487N>A | p.Asp163Asn | p.D163N | Q99592 | protein_coding | tolerated(0.48) | benign(0.284) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ZBTB18 | SNV | Missense_Mutation | rs756323931 | c.487G>A | p.Asp163Asn | p.D163N | Q99592 | protein_coding | tolerated(0.48) | benign(0.284) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
| ZBTB18 | SNV | Missense_Mutation | c.1156N>G | p.Lys386Glu | p.K386E | Q99592 | protein_coding | deleterious(0.02) | possibly_damaging(0.549) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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