Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ZBTB16

Gene summary for ZBTB16

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ZBTB16

Gene ID

7704

Gene namezinc finger and BTB domain containing 16
Gene AliasPLZF
Cytomap11q23.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

A0A024R3C6


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7704ZBTB16HTA11_3410_2000001011HumanColorectumAD3.35e-25-7.67e-010.0155
7704ZBTB16HTA11_2487_2000001011HumanColorectumSER4.46e-09-6.94e-01-0.1808
7704ZBTB16HTA11_1938_2000001011HumanColorectumAD2.71e-09-7.46e-01-0.0811
7704ZBTB16HTA11_78_2000001011HumanColorectumAD5.50e-13-7.22e-01-0.1088
7704ZBTB16HTA11_347_2000001011HumanColorectumAD6.24e-19-7.12e-01-0.1954
7704ZBTB16HTA11_3361_2000001011HumanColorectumAD9.33e-10-7.47e-01-0.1207
7704ZBTB16HTA11_83_2000001011HumanColorectumSER1.58e-10-7.72e-01-0.1526
7704ZBTB16HTA11_696_2000001011HumanColorectumAD3.42e-25-7.08e-01-0.1464
7704ZBTB16HTA11_866_2000001011HumanColorectumAD4.22e-19-6.92e-01-0.1001
7704ZBTB16HTA11_1391_2000001011HumanColorectumAD2.36e-14-7.09e-01-0.059
7704ZBTB16HTA11_5212_2000001011HumanColorectumAD1.65e-03-7.47e-01-0.2061
7704ZBTB16HTA11_546_2000001011HumanColorectumAD6.40e-06-7.37e-01-0.0842
7704ZBTB16HTA11_7862_2000001011HumanColorectumAD2.65e-07-7.72e-01-0.0179
7704ZBTB16HTA11_866_3004761011HumanColorectumAD6.36e-20-7.53e-010.096
7704ZBTB16HTA11_4255_2000001011HumanColorectumSER1.69e-03-7.72e-010.0446
7704ZBTB16HTA11_8622_2000001021HumanColorectumSER6.49e-04-7.48e-010.0528
7704ZBTB16HTA11_10623_2000001011HumanColorectumAD6.88e-04-7.28e-01-0.0177
7704ZBTB16HTA11_6801_2000001011HumanColorectumSER4.90e-03-7.72e-010.0171
7704ZBTB16HTA11_10711_2000001011HumanColorectumAD5.25e-12-7.51e-010.0338
7704ZBTB16HTA11_7696_3000711011HumanColorectumAD5.65e-31-7.64e-010.0674
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0030099ColorectumADmyeloid cell differentiation119/3918381/187231.24e-064.01e-05119
GO:0034504ColorectumADprotein localization to nucleus94/3918290/187232.83e-068.09e-0594
GO:0045785ColorectumADpositive regulation of cell adhesion122/3918437/187232.65e-043.28e-03122
GO:1903706ColorectumADregulation of hemopoiesis99/3918367/187233.08e-032.28e-0299
GO:0045637ColorectumADregulation of myeloid cell differentiation61/3918210/187233.17e-032.35e-0261
GO:0048736ColorectumADappendage development51/3918172/187234.20e-032.89e-0251
GO:0060173ColorectumADlimb development51/3918172/187234.20e-032.89e-0251
GO:0001503ColorectumADossification106/3918408/187237.68e-034.64e-02106
GO:0001865ColorectumADNK T cell differentiation6/391810/187238.03e-034.73e-026
GO:00345041ColorectumSERprotein localization to nucleus74/2897290/187235.74e-062.05e-0474
GO:00457851ColorectumSERpositive regulation of cell adhesion93/2897437/187236.78e-049.04e-0393
GO:00487361ColorectumSERappendage development42/2897172/187231.43e-031.55e-0242
GO:00601731ColorectumSERlimb development42/2897172/187231.43e-031.55e-0242
GO:00300991ColorectumSERmyeloid cell differentiation80/2897381/187232.28e-032.18e-0280
GO:0045444ColorectumSERfat cell differentiation51/2897229/187233.96e-033.26e-0251
GO:0045600ColorectumSERpositive regulation of fat cell differentiation19/289766/187234.29e-033.45e-0219
GO:0035107ColorectumSERappendage morphogenesis33/2897138/187236.10e-034.42e-0233
GO:0035108ColorectumSERlimb morphogenesis33/2897138/187236.10e-034.42e-0233
GO:00015031ColorectumSERossification82/2897408/187236.76e-034.78e-0282
GO:00345042ColorectumMSSprotein localization to nucleus92/3467290/187233.66e-081.98e-0692
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05202ColorectumFAPTranscriptional misregulation in cancer45/1404193/84659.19e-033.33e-022.03e-0245
hsa052021ColorectumFAPTranscriptional misregulation in cancer45/1404193/84659.19e-033.33e-022.03e-0245
hsa052026LungIACTranscriptional misregulation in cancer40/1053193/84656.90e-045.90e-033.92e-0340
hsa0520211LungIACTranscriptional misregulation in cancer40/1053193/84656.90e-045.90e-033.92e-0340
hsa052022LungAISTranscriptional misregulation in cancer39/961193/84652.15e-042.41e-031.54e-0339
hsa052023LungAISTranscriptional misregulation in cancer39/961193/84652.15e-042.41e-031.54e-0339
hsa052024LungMIACTranscriptional misregulation in cancer22/507193/84652.64e-032.26e-021.64e-0222
hsa052025LungMIACTranscriptional misregulation in cancer22/507193/84652.64e-032.26e-021.64e-0222
hsa052027ProstateBPHTranscriptional misregulation in cancer53/1718193/84659.56e-032.92e-021.81e-0253
hsa0520212ProstateBPHTranscriptional misregulation in cancer53/1718193/84659.56e-032.92e-021.81e-0253
hsa0520221ProstateTumorTranscriptional misregulation in cancer59/1791193/84651.22e-035.26e-033.26e-0359
hsa0520231ProstateTumorTranscriptional misregulation in cancer59/1791193/84651.22e-035.26e-033.26e-0359
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
ZBTB16EEStomachHealthyERO1B,ERP27,PABPC4, etc.3.39e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ZBTB16SNVMissense_Mutationc.701G>Tp.Arg234Leup.R234LQ05516protein_codingtolerated(0.71)benign(0.007)TCGA-A2-A25A-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificCytoxanSD
ZBTB16SNVMissense_Mutationrs779712380c.1234G>Ap.Glu412Lysp.E412KQ05516protein_codingtolerated(0.19)benign(0.089)TCGA-A8-A06Q-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
ZBTB16SNVMissense_Mutationc.1009N>Gp.Leu337Valp.L337VQ05516protein_codingtolerated(0.53)benign(0.05)TCGA-A8-A09I-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
ZBTB16SNVMissense_Mutationc.272N>Tp.Thr91Metp.T91MQ05516protein_codingdeleterious(0)probably_damaging(0.933)TCGA-C8-A12T-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
ZBTB16SNVMissense_Mutationnovelc.363N>Tp.Met121Ilep.M121IQ05516protein_codingtolerated(1)benign(0)TCGA-UU-A93S-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownPD
ZBTB16insertionFrame_Shift_Insnovelc.1567_1568insTGATCAATGTCTATCCTTTAp.Cys523LeufsTer102p.C523Lfs*102Q05516protein_codingTCGA-B6-A0IC-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ZBTB16SNVMissense_Mutationrs747010083c.1337N>Ap.Arg446Glnp.R446QQ05516protein_codingdeleterious(0)probably_damaging(0.988)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ZBTB16SNVMissense_Mutationnovelc.901N>Ap.Glu301Lysp.E301KQ05516protein_codingtolerated(0.12)benign(0.037)TCGA-C5-A7CG-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
ZBTB16SNVMissense_Mutationnovelc.765C>Ap.Asp255Glup.D255EQ05516protein_codingtolerated(1)benign(0)TCGA-C5-A8YQ-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
ZBTB16SNVMissense_Mutationc.995N>Tp.Gly332Valp.G332VQ05516protein_codingtolerated(0.06)benign(0.154)TCGA-EK-A2PM-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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