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Gene: ZBED5 |
Gene summary for ZBED5 |
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Gene information | Species | Human | Gene symbol | ZBED5 | Gene ID | 58486 |
Gene name | zinc finger BED-type containing 5 | |
Gene Alias | Buster1 | |
Cytomap | 11p15.4 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q49AG3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
58486 | ZBED5 | LZE4T | Human | Esophagus | ESCC | 5.65e-11 | 3.39e-01 | 0.0811 |
58486 | ZBED5 | LZE5T | Human | Esophagus | ESCC | 3.02e-06 | 3.57e-01 | 0.0514 |
58486 | ZBED5 | LZE7T | Human | Esophagus | ESCC | 1.92e-09 | 4.62e-01 | 0.0667 |
58486 | ZBED5 | LZE8T | Human | Esophagus | ESCC | 5.72e-09 | 2.17e-01 | 0.067 |
58486 | ZBED5 | LZE20T | Human | Esophagus | ESCC | 8.78e-03 | 1.39e-01 | 0.0662 |
58486 | ZBED5 | LZE24T | Human | Esophagus | ESCC | 4.95e-19 | 4.26e-01 | 0.0596 |
58486 | ZBED5 | LZE21T | Human | Esophagus | ESCC | 2.52e-04 | 2.63e-01 | 0.0655 |
58486 | ZBED5 | LZE6T | Human | Esophagus | ESCC | 2.33e-03 | 1.77e-01 | 0.0845 |
58486 | ZBED5 | P1T-E | Human | Esophagus | ESCC | 2.52e-07 | 2.01e-01 | 0.0875 |
58486 | ZBED5 | P2T-E | Human | Esophagus | ESCC | 2.85e-32 | 6.96e-01 | 0.1177 |
58486 | ZBED5 | P4T-E | Human | Esophagus | ESCC | 1.18e-18 | 3.73e-01 | 0.1323 |
58486 | ZBED5 | P5T-E | Human | Esophagus | ESCC | 1.53e-07 | 9.42e-02 | 0.1327 |
58486 | ZBED5 | P8T-E | Human | Esophagus | ESCC | 7.60e-16 | 2.82e-01 | 0.0889 |
58486 | ZBED5 | P9T-E | Human | Esophagus | ESCC | 5.57e-18 | 3.77e-01 | 0.1131 |
58486 | ZBED5 | P10T-E | Human | Esophagus | ESCC | 6.43e-26 | 5.56e-01 | 0.116 |
58486 | ZBED5 | P11T-E | Human | Esophagus | ESCC | 5.27e-21 | 6.15e-01 | 0.1426 |
58486 | ZBED5 | P12T-E | Human | Esophagus | ESCC | 1.61e-16 | 3.16e-01 | 0.1122 |
58486 | ZBED5 | P15T-E | Human | Esophagus | ESCC | 3.93e-22 | 4.63e-01 | 0.1149 |
58486 | ZBED5 | P16T-E | Human | Esophagus | ESCC | 2.38e-26 | 4.36e-01 | 0.1153 |
58486 | ZBED5 | P17T-E | Human | Esophagus | ESCC | 1.81e-09 | 3.84e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBED5 | SNV | Missense_Mutation | novel | c.1794N>T | p.Leu598Phe | p.L598F | Q49AG3 | protein_coding | deleterious(0.01) | possibly_damaging(0.847) | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
ZBED5 | SNV | Missense_Mutation | novel | c.496A>T | p.Ser166Cys | p.S166C | Q49AG3 | protein_coding | deleterious(0.02) | possibly_damaging(0.894) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
ZBED5 | SNV | Missense_Mutation | rs550859125 | c.1345N>T | p.Arg449Cys | p.R449C | Q49AG3 | protein_coding | deleterious(0.04) | possibly_damaging(0.473) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBED5 | SNV | Missense_Mutation | novel | c.1000N>A | p.Glu334Lys | p.E334K | Q49AG3 | protein_coding | tolerated(0.57) | benign(0.025) | TCGA-AR-A5QQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
ZBED5 | SNV | Missense_Mutation | novel | c.268N>C | p.Val90Leu | p.V90L | Q49AG3 | protein_coding | tolerated_low_confidence(0.22) | benign(0.014) | TCGA-E2-A15S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ZBED5 | SNV | Missense_Mutation | novel | c.929C>G | p.Ser310Cys | p.S310C | Q49AG3 | protein_coding | tolerated(0.2) | probably_damaging(0.947) | TCGA-E9-A3HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
ZBED5 | SNV | Missense_Mutation | novel | c.701A>G | p.Tyr234Cys | p.Y234C | Q49AG3 | protein_coding | tolerated(0.16) | benign(0.054) | TCGA-EA-A3Y4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZBED5 | SNV | Missense_Mutation | c.197G>A | p.Gly66Glu | p.G66E | Q49AG3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.988) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZBED5 | SNV | Missense_Mutation | novel | c.1906N>T | p.Leu636Phe | p.L636F | Q49AG3 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
ZBED5 | SNV | Missense_Mutation | novel | c.1927N>A | p.Leu643Met | p.L643M | Q49AG3 | protein_coding | tolerated(0.07) | probably_damaging(0.942) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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