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Gene: YPEL1 |
Gene summary for YPEL1 |
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Gene information | Species | Human | Gene symbol | YPEL1 | Gene ID | 29799 |
Gene name | yippee like 1 | |
Gene Alias | FKSG3 | |
Cytomap | 22q11.21-q11.22 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O60688 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29799 | YPEL1 | HCC1_Meng | Human | Liver | HCC | 1.04e-02 | -2.31e-02 | 0.0246 |
29799 | YPEL1 | HCC1 | Human | Liver | HCC | 9.45e-09 | 2.92e+00 | 0.5336 |
29799 | YPEL1 | HCC2 | Human | Liver | HCC | 3.66e-25 | 2.32e+00 | 0.5341 |
29799 | YPEL1 | HCC5 | Human | Liver | HCC | 3.53e-16 | 2.61e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YPEL1 | SNV | Missense_Mutation | c.68N>A | p.Cys23Tyr | p.C23Y | O60688 | protein_coding | deleterious(0) | benign(0.036) | TCGA-E9-A1NE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
YPEL1 | insertion | Frame_Shift_Ins | novel | c.40_41insCAGGGCCAGGCAGCTGGCACTCCCAGGGATTACGAGGGGCAAGG | p.Leu14ProfsTer57 | p.L14Pfs*57 | O60688 | protein_coding | TCGA-A2-A0T2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | ||
YPEL1 | insertion | Nonsense_Mutation | novel | c.318_319insTGAGTCTCTGAAGACCACAGG | p.Ile106_Ile107insTer | p.I106_I107ins* | O60688 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
YPEL1 | SNV | Missense_Mutation | novel | c.322G>C | p.Glu108Gln | p.E108Q | O60688 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-DS-A5RQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
YPEL1 | SNV | Missense_Mutation | novel | c.182N>A | p.Pro61His | p.P61H | O60688 | protein_coding | deleterious(0.01) | possibly_damaging(0.879) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
YPEL1 | SNV | Missense_Mutation | rs759424839 | c.59C>T | p.Thr20Met | p.T20M | O60688 | protein_coding | deleterious(0.04) | possibly_damaging(0.677) | TCGA-A6-2684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
YPEL1 | SNV | Missense_Mutation | novel | c.305N>C | p.Glu102Ala | p.E102A | O60688 | protein_coding | deleterious(0) | possibly_damaging(0.779) | TCGA-AA-3695-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
YPEL1 | SNV | Missense_Mutation | c.202C>A | p.Leu68Ile | p.L68I | O60688 | protein_coding | tolerated(0.25) | benign(0.15) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
YPEL1 | SNV | Missense_Mutation | c.107N>A | p.Leu36His | p.L36H | O60688 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CL-5918-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
YPEL1 | SNV | Missense_Mutation | novel | c.218N>T | p.Ala73Val | p.A73V | O60688 | protein_coding | tolerated(0.14) | benign(0.019) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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