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Gene: YIPF2 |
Gene summary for YIPF2 |
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Gene information | Species | Human | Gene symbol | YIPF2 | Gene ID | 78992 |
Gene name | Yip1 domain family member 2 | |
Gene Alias | FinGER2 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R7E1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
78992 | YIPF2 | LZE4T | Human | Esophagus | ESCC | 1.26e-09 | 1.54e-01 | 0.0811 |
78992 | YIPF2 | LZE5T | Human | Esophagus | ESCC | 1.98e-02 | 4.31e-01 | 0.0514 |
78992 | YIPF2 | LZE7T | Human | Esophagus | ESCC | 6.62e-11 | 6.68e-01 | 0.0667 |
78992 | YIPF2 | LZE8T | Human | Esophagus | ESCC | 1.55e-06 | 1.42e-01 | 0.067 |
78992 | YIPF2 | LZE20T | Human | Esophagus | ESCC | 1.74e-05 | 2.73e-01 | 0.0662 |
78992 | YIPF2 | LZE22T | Human | Esophagus | ESCC | 7.60e-05 | 4.98e-01 | 0.068 |
78992 | YIPF2 | LZE24T | Human | Esophagus | ESCC | 1.45e-14 | 4.54e-01 | 0.0596 |
78992 | YIPF2 | P1T-E | Human | Esophagus | ESCC | 2.45e-08 | 5.56e-01 | 0.0875 |
78992 | YIPF2 | P2T-E | Human | Esophagus | ESCC | 1.56e-16 | 2.72e-01 | 0.1177 |
78992 | YIPF2 | P4T-E | Human | Esophagus | ESCC | 1.96e-23 | 5.65e-01 | 0.1323 |
78992 | YIPF2 | P5T-E | Human | Esophagus | ESCC | 5.76e-22 | 4.41e-01 | 0.1327 |
78992 | YIPF2 | P8T-E | Human | Esophagus | ESCC | 4.18e-36 | 7.54e-01 | 0.0889 |
78992 | YIPF2 | P9T-E | Human | Esophagus | ESCC | 3.13e-18 | 4.82e-01 | 0.1131 |
78992 | YIPF2 | P10T-E | Human | Esophagus | ESCC | 3.81e-45 | 8.76e-01 | 0.116 |
78992 | YIPF2 | P11T-E | Human | Esophagus | ESCC | 2.49e-19 | 9.21e-01 | 0.1426 |
78992 | YIPF2 | P12T-E | Human | Esophagus | ESCC | 1.21e-28 | 5.66e-01 | 0.1122 |
78992 | YIPF2 | P15T-E | Human | Esophagus | ESCC | 2.57e-16 | 2.89e-01 | 0.1149 |
78992 | YIPF2 | P16T-E | Human | Esophagus | ESCC | 1.52e-22 | 5.04e-01 | 0.1153 |
78992 | YIPF2 | P17T-E | Human | Esophagus | ESCC | 2.92e-18 | 7.10e-01 | 0.1278 |
78992 | YIPF2 | P19T-E | Human | Esophagus | ESCC | 2.80e-07 | 9.76e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
YIPF2 | SNV | Missense_Mutation | c.406N>A | p.Ala136Thr | p.A136T | Q9BWQ6 | protein_coding | tolerated(0.06) | possibly_damaging(0.642) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
YIPF2 | SNV | Missense_Mutation | c.252N>C | p.Gln84His | p.Q84H | Q9BWQ6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
YIPF2 | SNV | Missense_Mutation | c.757G>A | p.Glu253Lys | p.E253K | Q9BWQ6 | protein_coding | deleterious(0.04) | benign(0.136) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
YIPF2 | SNV | Missense_Mutation | novel | c.170N>T | p.Glu57Val | p.E57V | Q9BWQ6 | protein_coding | tolerated(0.19) | benign(0.12) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
YIPF2 | SNV | Missense_Mutation | c.254N>T | p.Ser85Ile | p.S85I | Q9BWQ6 | protein_coding | deleterious(0.01) | benign(0.312) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
YIPF2 | SNV | Missense_Mutation | c.331N>A | p.Val111Met | p.V111M | Q9BWQ6 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
YIPF2 | SNV | Missense_Mutation | c.86N>C | p.Ser29Thr | p.S29T | Q9BWQ6 | protein_coding | tolerated(0.1) | benign(0.028) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
YIPF2 | SNV | Missense_Mutation | novel | c.234G>T | p.Trp78Cys | p.W78C | Q9BWQ6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
YIPF2 | SNV | Missense_Mutation | rs753018051 | c.776N>T | p.Ala259Val | p.A259V | Q9BWQ6 | protein_coding | tolerated(0.18) | possibly_damaging(0.49) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
YIPF2 | SNV | Missense_Mutation | novel | c.202G>A | p.Glu68Lys | p.E68K | Q9BWQ6 | protein_coding | tolerated(0.37) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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