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Gene: XPNPEP3 |
Gene summary for XPNPEP3 |
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Gene information | Species | Human | Gene symbol | XPNPEP3 | Gene ID | 63929 |
Gene name | X-prolyl aminopeptidase 3 | |
Gene Alias | APP3 | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | A0A087X0Z2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63929 | XPNPEP3 | LZE4T | Human | Esophagus | ESCC | 9.15e-05 | 1.42e-01 | 0.0811 |
63929 | XPNPEP3 | LZE7T | Human | Esophagus | ESCC | 8.56e-03 | 2.43e-01 | 0.0667 |
63929 | XPNPEP3 | LZE8T | Human | Esophagus | ESCC | 7.34e-04 | 1.15e-01 | 0.067 |
63929 | XPNPEP3 | LZE20T | Human | Esophagus | ESCC | 7.38e-08 | 1.99e-01 | 0.0662 |
63929 | XPNPEP3 | LZE24T | Human | Esophagus | ESCC | 1.96e-15 | 4.32e-01 | 0.0596 |
63929 | XPNPEP3 | LZE6T | Human | Esophagus | ESCC | 1.02e-04 | 1.94e-01 | 0.0845 |
63929 | XPNPEP3 | P1T-E | Human | Esophagus | ESCC | 1.35e-04 | 2.90e-01 | 0.0875 |
63929 | XPNPEP3 | P2T-E | Human | Esophagus | ESCC | 3.98e-24 | 3.81e-01 | 0.1177 |
63929 | XPNPEP3 | P4T-E | Human | Esophagus | ESCC | 2.56e-17 | 3.28e-01 | 0.1323 |
63929 | XPNPEP3 | P5T-E | Human | Esophagus | ESCC | 4.85e-11 | 2.26e-01 | 0.1327 |
63929 | XPNPEP3 | P8T-E | Human | Esophagus | ESCC | 1.64e-15 | 3.13e-01 | 0.0889 |
63929 | XPNPEP3 | P9T-E | Human | Esophagus | ESCC | 3.49e-11 | 2.37e-01 | 0.1131 |
63929 | XPNPEP3 | P10T-E | Human | Esophagus | ESCC | 3.89e-27 | 4.67e-01 | 0.116 |
63929 | XPNPEP3 | P11T-E | Human | Esophagus | ESCC | 7.35e-06 | 3.22e-01 | 0.1426 |
63929 | XPNPEP3 | P12T-E | Human | Esophagus | ESCC | 2.65e-16 | 3.50e-01 | 0.1122 |
63929 | XPNPEP3 | P15T-E | Human | Esophagus | ESCC | 6.09e-21 | 4.12e-01 | 0.1149 |
63929 | XPNPEP3 | P16T-E | Human | Esophagus | ESCC | 3.81e-24 | 4.78e-01 | 0.1153 |
63929 | XPNPEP3 | P17T-E | Human | Esophagus | ESCC | 6.33e-06 | 1.81e-01 | 0.1278 |
63929 | XPNPEP3 | P19T-E | Human | Esophagus | ESCC | 5.64e-04 | 2.41e-01 | 0.1662 |
63929 | XPNPEP3 | P20T-E | Human | Esophagus | ESCC | 6.00e-19 | 3.44e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:001648511 | Liver | HCC | protein processing | 121/7958 | 225/18723 | 4.01e-04 | 2.71e-03 | 121 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
XPNPEP3 | SNV | Missense_Mutation | c.1238N>A | p.Ala413Asp | p.A413D | Q9NQH7 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-A8-A076-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
XPNPEP3 | SNV | Missense_Mutation | rs768828532 | c.1049A>G | p.Asn350Ser | p.N350S | Q9NQH7 | protein_coding | tolerated(0.34) | possibly_damaging(0.487) | TCGA-E2-A15H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | herceptin | SD |
XPNPEP3 | SNV | Missense_Mutation | c.31N>C | p.Val11Leu | p.V11L | Q9NQH7 | protein_coding | tolerated_low_confidence(0.7) | benign(0) | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
XPNPEP3 | deletion | In_Frame_Del | novel | c.225_230delNNNNNN | p.Arg76_His77del | p.R76_H77del | Q9NQH7 | protein_coding | TCGA-GM-A3XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR | ||
XPNPEP3 | SNV | Missense_Mutation | novel | c.1519N>C | p.Ser507Pro | p.S507P | Q9NQH7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.011) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
XPNPEP3 | SNV | Missense_Mutation | rs769806045 | c.925N>T | p.Arg309Trp | p.R309W | Q9NQH7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
XPNPEP3 | SNV | Missense_Mutation | rs769655576 | c.224N>A | p.Arg75His | p.R75H | Q9NQH7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
XPNPEP3 | SNV | Missense_Mutation | rs752721668 | c.725N>A | p.Arg242His | p.R242H | Q9NQH7 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
XPNPEP3 | SNV | Missense_Mutation | c.379N>A | p.Phe127Ile | p.F127I | Q9NQH7 | protein_coding | tolerated(0.1) | benign(0.429) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
XPNPEP3 | SNV | Missense_Mutation | c.844N>A | p.Leu282Ile | p.L282I | Q9NQH7 | protein_coding | tolerated(0.1) | possibly_damaging(0.841) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
63929 | XPNPEP3 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL2103847 | TOSEDOSTAT |
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