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Gene: XPNPEP1 |
Gene summary for XPNPEP1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | XPNPEP1 | Gene ID | 7511 |
| Gene name | X-prolyl aminopeptidase 1 | |
| Gene Alias | APP1 | |
| Cytomap | 10q25.1 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9NQW7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7511 | XPNPEP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.65e-06 | 4.00e-01 | -0.1954 |
| 7511 | XPNPEP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 8.34e-03 | 7.65e-01 | -0.2602 |
| 7511 | XPNPEP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.50e-02 | 3.68e-01 | -0.059 |
| 7511 | XPNPEP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.65e-07 | 4.79e-01 | 0.294 |
| 7511 | XPNPEP1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.38e-03 | 4.54e-01 | 0.281 |
| 7511 | XPNPEP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.68e-10 | 6.42e-01 | 0.3859 |
| 7511 | XPNPEP1 | A015-C-203 | Human | Colorectum | FAP | 9.31e-06 | -1.99e-01 | -0.1294 |
| 7511 | XPNPEP1 | A002-C-201 | Human | Colorectum | FAP | 2.69e-02 | -1.56e-01 | 0.0324 |
| 7511 | XPNPEP1 | A002-C-205 | Human | Colorectum | FAP | 2.14e-06 | -2.08e-01 | -0.1236 |
| 7511 | XPNPEP1 | A015-C-006 | Human | Colorectum | FAP | 5.33e-05 | -2.57e-01 | -0.0994 |
| 7511 | XPNPEP1 | A015-C-106 | Human | Colorectum | FAP | 1.33e-03 | -1.47e-01 | -0.0511 |
| 7511 | XPNPEP1 | A002-C-114 | Human | Colorectum | FAP | 1.41e-03 | -1.43e-01 | -0.1561 |
| 7511 | XPNPEP1 | A015-C-104 | Human | Colorectum | FAP | 2.28e-06 | -2.13e-01 | -0.1899 |
| 7511 | XPNPEP1 | A001-C-014 | Human | Colorectum | FAP | 1.58e-02 | -8.83e-02 | 0.0135 |
| 7511 | XPNPEP1 | A002-C-016 | Human | Colorectum | FAP | 1.94e-04 | -1.66e-01 | 0.0521 |
| 7511 | XPNPEP1 | A001-C-203 | Human | Colorectum | FAP | 5.52e-03 | -1.49e-01 | -0.0481 |
| 7511 | XPNPEP1 | A002-C-116 | Human | Colorectum | FAP | 8.26e-10 | -2.11e-01 | -0.0452 |
| 7511 | XPNPEP1 | A018-E-020 | Human | Colorectum | FAP | 7.25e-05 | -1.99e-01 | -0.2034 |
| 7511 | XPNPEP1 | F034 | Human | Colorectum | FAP | 4.09e-04 | -1.53e-01 | -0.0665 |
| 7511 | XPNPEP1 | LZE4T | Human | Esophagus | ESCC | 2.34e-05 | 1.20e-01 | 0.0811 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| XPNPEP1 | SNV | Missense_Mutation | novel | c.896N>T | p.Gly299Val | p.G299V | Q9NQW7 | protein_coding | deleterious(0.02) | benign(0.059) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |
| XPNPEP1 | SNV | Missense_Mutation | novel | c.512N>G | p.Tyr171Cys | p.Y171C | Q9NQW7 | protein_coding | tolerated(0.05) | benign(0.142) | TCGA-AR-A1AI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD |
| XPNPEP1 | SNV | Missense_Mutation | c.679N>A | p.Asp227Asn | p.D227N | Q9NQW7 | protein_coding | tolerated(0.48) | benign(0.005) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
| XPNPEP1 | SNV | Missense_Mutation | novel | c.128N>A | p.Arg43Lys | p.R43K | Q9NQW7 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
| XPNPEP1 | insertion | Frame_Shift_Ins | novel | c.132_133insTTTCTCACAAGAGTCCTAGGAGATGTGTGGGC | p.Pro45PhefsTer15 | p.P45Ffs*15 | Q9NQW7 | protein_coding | TCGA-AO-A03T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
| XPNPEP1 | insertion | Frame_Shift_Ins | novel | c.773_774insCCCATCACTGCCTGATATTTCACTGATGTGCT | p.Val259ProfsTer24 | p.V259Pfs*24 | Q9NQW7 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
| XPNPEP1 | SNV | Missense_Mutation | rs777814357 | c.1318G>A | p.Ala440Thr | p.A440T | Q9NQW7 | protein_coding | tolerated(0.54) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| XPNPEP1 | SNV | Missense_Mutation | novel | c.256A>G | p.Ile86Val | p.I86V | Q9NQW7 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| XPNPEP1 | SNV | Missense_Mutation | novel | c.1108N>C | p.Ser370Pro | p.S370P | Q9NQW7 | protein_coding | deleterious(0.01) | benign(0.436) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| XPNPEP1 | SNV | Missense_Mutation | c.376N>A | p.Ala126Thr | p.A126T | Q9NQW7 | protein_coding | tolerated(0.46) | benign(0.007) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 7511 | XPNPEP1 | ENZYME, PROTEASE, DRUGGABLE GENOME | inhibitor | CHEMBL2103847 | TOSEDOSTAT | |
| 7511 | XPNPEP1 | ENZYME, PROTEASE, DRUGGABLE GENOME | inhibitor | 252827461 |
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