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Gene: XIRP2 |
Gene summary for XIRP2 |
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Gene information | Species | Human | Gene symbol | XIRP2 | Gene ID | 129446 |
Gene name | xin actin binding repeat containing 2 | |
Gene Alias | CMYA3 | |
Cytomap | 2q24.3 | |
Gene Type | protein-coding | GO ID | GO:0003007 | UniProtAcc | A4UGR9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
129446 | XIRP2 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.62e-18 | 1.66e+00 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
XIRP2 | SNV | Missense_Mutation | c.8512G>A | p.Glu2838Lys | p.E2838K | A4UGR9 | protein_coding | deleterious(0.05) | benign(0.232) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
XIRP2 | SNV | Missense_Mutation | c.6941C>T | p.Pro2314Leu | p.P2314L | A4UGR9 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-A2-A1G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
XIRP2 | SNV | Missense_Mutation | c.4444G>T | p.Val1482Leu | p.V1482L | A4UGR9 | protein_coding | deleterious(0.03) | benign(0.073) | TCGA-A2-A1G1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
XIRP2 | SNV | Missense_Mutation | c.9293N>A | p.Thr3098Asn | p.T3098N | A4UGR9 | protein_coding | tolerated(0.07) | benign(0.219) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
XIRP2 | SNV | Missense_Mutation | c.742N>G | p.Met248Val | p.M248V | A4UGR9 | protein_coding | tolerated(1) | benign(0.036) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
XIRP2 | SNV | Missense_Mutation | c.10323N>A | p.Ser3441Arg | p.S3441R | A4UGR9 | protein_coding | deleterious(0.01) | benign(0.414) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
XIRP2 | SNV | Missense_Mutation | novel | c.2918N>C | p.Arg973Thr | p.R973T | A4UGR9 | protein_coding | tolerated(0.13) | benign(0.369) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
XIRP2 | SNV | Missense_Mutation | novel | c.3907N>A | p.Glu1303Lys | p.E1303K | A4UGR9 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
XIRP2 | SNV | Missense_Mutation | c.8644N>C | p.Glu2882Gln | p.E2882Q | A4UGR9 | protein_coding | tolerated(0.26) | benign(0.025) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
XIRP2 | SNV | Missense_Mutation | rs576110894 | c.9278N>A | p.Arg3093His | p.R3093H | A4UGR9 | protein_coding | tolerated(1) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
129446 | XIRP2 | NA | atenolol | ATENOLOL |
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