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Gene: WTIP |
Gene summary for WTIP |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | WTIP | Gene ID | 126374 |
| Gene name | WT1 interacting protein | |
| Gene Alias | WTIP | |
| Cytomap | 19q13.11 | |
| Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A6NIX2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 126374 | WTIP | male-WTA | Human | Thyroid | PTC | 3.94e-14 | 2.25e-01 | 0.1037 |
| 126374 | WTIP | PTC01 | Human | Thyroid | PTC | 3.00e-08 | 1.69e-01 | 0.1899 |
| 126374 | WTIP | PTC03 | Human | Thyroid | PTC | 1.79e-02 | 1.58e-01 | 0.1784 |
| 126374 | WTIP | PTC04 | Human | Thyroid | PTC | 5.21e-17 | 3.73e-01 | 0.1927 |
| 126374 | WTIP | PTC05 | Human | Thyroid | PTC | 1.04e-21 | 6.44e-01 | 0.2065 |
| 126374 | WTIP | PTC06 | Human | Thyroid | PTC | 3.49e-37 | 7.83e-01 | 0.2057 |
| 126374 | WTIP | PTC07 | Human | Thyroid | PTC | 2.12e-37 | 6.45e-01 | 0.2044 |
| 126374 | WTIP | ATC12 | Human | Thyroid | ATC | 6.97e-05 | 1.36e-01 | 0.34 |
| 126374 | WTIP | ATC13 | Human | Thyroid | ATC | 5.13e-86 | 1.46e+00 | 0.34 |
| 126374 | WTIP | ATC2 | Human | Thyroid | ATC | 1.24e-20 | 1.14e+00 | 0.34 |
| 126374 | WTIP | ATC3 | Human | Thyroid | ATC | 6.22e-03 | 2.27e-01 | 0.338 |
| 126374 | WTIP | ATC4 | Human | Thyroid | ATC | 1.06e-08 | 1.84e-01 | 0.34 |
| 126374 | WTIP | ATC5 | Human | Thyroid | ATC | 6.30e-83 | 1.53e+00 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022604112 | Thyroid | PTC | regulation of cell morphogenesis | 165/5968 | 309/18723 | 2.60e-15 | 1.82e-13 | 165 |
| GO:0070482113 | Thyroid | PTC | response to oxygen levels | 167/5968 | 347/18723 | 1.51e-10 | 5.03e-09 | 167 |
| GO:0036293113 | Thyroid | PTC | response to decreased oxygen levels | 153/5968 | 322/18723 | 2.71e-09 | 7.52e-08 | 153 |
| GO:0001666113 | Thyroid | PTC | response to hypoxia | 145/5968 | 307/18723 | 1.14e-08 | 2.74e-07 | 145 |
| GO:006014816 | Thyroid | PTC | positive regulation of posttranscriptional gene silencing | 21/5968 | 31/18723 | 4.43e-05 | 4.02e-04 | 21 |
| GO:200063716 | Thyroid | PTC | positive regulation of gene silencing by miRNA | 20/5968 | 30/18723 | 9.53e-05 | 7.85e-04 | 20 |
| GO:003532912 | Thyroid | PTC | hippo signaling | 24/5968 | 40/18723 | 2.27e-04 | 1.65e-03 | 24 |
| GO:006014716 | Thyroid | PTC | regulation of posttranscriptional gene silencing | 29/5968 | 52/18723 | 3.09e-04 | 2.15e-03 | 29 |
| GO:00609669 | Thyroid | PTC | regulation of gene silencing by RNA | 29/5968 | 53/18723 | 4.76e-04 | 3.13e-03 | 29 |
| GO:006096417 | Thyroid | PTC | regulation of gene silencing by miRNA | 27/5968 | 49/18723 | 6.38e-04 | 4.02e-03 | 27 |
| GO:00609688 | Thyroid | PTC | regulation of gene silencing | 36/5968 | 81/18723 | 1.18e-02 | 4.64e-02 | 36 |
| GO:007048228 | Thyroid | ATC | response to oxygen levels | 193/6293 | 347/18723 | 1.83e-17 | 1.93e-15 | 193 |
| GO:003629328 | Thyroid | ATC | response to decreased oxygen levels | 177/6293 | 322/18723 | 1.81e-15 | 1.32e-13 | 177 |
| GO:002260429 | Thyroid | ATC | regulation of cell morphogenesis | 171/6293 | 309/18723 | 2.36e-15 | 1.70e-13 | 171 |
| GO:000166628 | Thyroid | ATC | response to hypoxia | 169/6293 | 307/18723 | 6.58e-15 | 4.12e-13 | 169 |
| GO:006014823 | Thyroid | ATC | positive regulation of posttranscriptional gene silencing | 22/6293 | 31/18723 | 2.35e-05 | 2.06e-04 | 22 |
| GO:200063724 | Thyroid | ATC | positive regulation of gene silencing by miRNA | 21/6293 | 30/18723 | 5.03e-05 | 3.96e-04 | 21 |
| GO:006014717 | Thyroid | ATC | regulation of posttranscriptional gene silencing | 31/6293 | 52/18723 | 1.06e-04 | 7.61e-04 | 31 |
| GO:006096616 | Thyroid | ATC | regulation of gene silencing by RNA | 31/6293 | 53/18723 | 1.74e-04 | 1.19e-03 | 31 |
| GO:006096418 | Thyroid | ATC | regulation of gene silencing by miRNA | 29/6293 | 49/18723 | 2.11e-04 | 1.39e-03 | 29 |
| Page: 1 2 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| WTIP | SNV | Missense_Mutation | c.895N>A | p.Glu299Lys | p.E299K | A6NIX2 | protein_coding | deleterious(0.01) | possibly_damaging(0.9) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| WTIP | SNV | Missense_Mutation | c.1208N>A | p.Gly403Asp | p.G403D | A6NIX2 | protein_coding | tolerated(0.5) | possibly_damaging(0.842) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
| WTIP | SNV | Missense_Mutation | novel | c.1012T>C | p.Cys338Arg | p.C338R | A6NIX2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| WTIP | SNV | Missense_Mutation | rs370840550 | c.782N>A | p.Arg261His | p.R261H | A6NIX2 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| WTIP | SNV | Missense_Mutation | novel | c.868T>G | p.Cys290Gly | p.C290G | A6NIX2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| WTIP | SNV | Missense_Mutation | novel | c.818A>T | p.Tyr273Phe | p.Y273F | A6NIX2 | protein_coding | tolerated(0.46) | possibly_damaging(0.549) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
| WTIP | SNV | Missense_Mutation | novel | c.778N>T | p.Leu260Phe | p.L260F | A6NIX2 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| WTIP | SNV | Missense_Mutation | c.1184N>T | p.Gly395Val | p.G395V | A6NIX2 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AX-A1C7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | topotecan | SD | |
| WTIP | SNV | Missense_Mutation | novel | c.802G>A | p.Val268Met | p.V268M | A6NIX2 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| WTIP | SNV | Missense_Mutation | c.1208N>A | p.Gly403Asp | p.G403D | A6NIX2 | protein_coding | tolerated(0.5) | possibly_damaging(0.842) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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