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Gene: WRB |
Gene summary for WRB |
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Gene information | Species | Human | Gene symbol | WRB | Gene ID | 7485 |
Gene name | guided entry of tail-anchored proteins factor 1 | |
Gene Alias | CHD5 | |
Cytomap | 21q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | O00258 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7485 | WRB | P1T-E | Human | Esophagus | ESCC | 1.97e-07 | 2.30e-01 | 0.0875 |
7485 | WRB | P2T-E | Human | Esophagus | ESCC | 6.57e-15 | 3.32e-01 | 0.1177 |
7485 | WRB | P4T-E | Human | Esophagus | ESCC | 1.15e-32 | 6.94e-01 | 0.1323 |
7485 | WRB | P5T-E | Human | Esophagus | ESCC | 1.64e-09 | 1.81e-01 | 0.1327 |
7485 | WRB | P8T-E | Human | Esophagus | ESCC | 4.91e-15 | 2.54e-01 | 0.0889 |
7485 | WRB | P9T-E | Human | Esophagus | ESCC | 2.36e-08 | 1.93e-01 | 0.1131 |
7485 | WRB | P10T-E | Human | Esophagus | ESCC | 2.19e-23 | 5.09e-01 | 0.116 |
7485 | WRB | P11T-E | Human | Esophagus | ESCC | 2.91e-15 | 4.31e-01 | 0.1426 |
7485 | WRB | P12T-E | Human | Esophagus | ESCC | 3.09e-14 | 3.53e-01 | 0.1122 |
7485 | WRB | P15T-E | Human | Esophagus | ESCC | 2.72e-07 | 1.89e-01 | 0.1149 |
7485 | WRB | P16T-E | Human | Esophagus | ESCC | 5.61e-23 | 4.88e-01 | 0.1153 |
7485 | WRB | P17T-E | Human | Esophagus | ESCC | 2.87e-05 | 2.22e-01 | 0.1278 |
7485 | WRB | P19T-E | Human | Esophagus | ESCC | 8.16e-10 | 4.71e-01 | 0.1662 |
7485 | WRB | P20T-E | Human | Esophagus | ESCC | 4.64e-15 | 2.09e-01 | 0.1124 |
7485 | WRB | P21T-E | Human | Esophagus | ESCC | 6.05e-19 | 3.61e-01 | 0.1617 |
7485 | WRB | P22T-E | Human | Esophagus | ESCC | 5.44e-23 | 3.52e-01 | 0.1236 |
7485 | WRB | P23T-E | Human | Esophagus | ESCC | 2.67e-17 | 3.34e-01 | 0.108 |
7485 | WRB | P24T-E | Human | Esophagus | ESCC | 2.18e-08 | 1.88e-01 | 0.1287 |
7485 | WRB | P26T-E | Human | Esophagus | ESCC | 9.79e-21 | 3.88e-01 | 0.1276 |
7485 | WRB | P27T-E | Human | Esophagus | ESCC | 1.96e-17 | 3.74e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WRB | SNV | Missense_Mutation | novel | c.352N>C | p.Ser118Pro | p.S118P | O00258 | protein_coding | tolerated(0.12) | probably_damaging(0.952) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
WRB | SNV | Missense_Mutation | novel | c.257T>C | p.Leu86Pro | p.L86P | O00258 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WRB | SNV | Missense_Mutation | c.209C>T | p.Ala70Val | p.A70V | O00258 | protein_coding | tolerated(0.06) | probably_damaging(0.961) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WRB | SNV | Missense_Mutation | c.182N>T | p.Ser61Phe | p.S61F | O00258 | protein_coding | deleterious(0.01) | possibly_damaging(0.54) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
WRB | SNV | Missense_Mutation | rs376882781 | c.248N>T | p.Thr83Met | p.T83M | O00258 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WRB | SNV | Missense_Mutation | c.413C>A | p.Pro138His | p.P138H | O00258 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A0LD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WRB | SNV | Missense_Mutation | novel | c.68T>C | p.Val23Ala | p.V23A | O00258 | protein_coding | tolerated(0.05) | benign(0.001) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WRB | SNV | Missense_Mutation | c.156G>T | p.Glu52Asp | p.E52D | O00258 | protein_coding | tolerated(0.06) | benign(0.133) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WRB | SNV | Missense_Mutation | novel | c.356T>C | p.Leu119Pro | p.L119P | O00258 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
WRB | SNV | Missense_Mutation | novel | c.338N>T | p.Ala113Val | p.A113V | O00258 | protein_coding | tolerated(0.06) | benign(0.211) | TCGA-SL-A6JA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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