Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: WNK3

Gene summary for WNK3

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

WNK3

Gene ID

65267

Gene nameWNK lysine deficient protein kinase 3
Gene AliasPRKWNK3
CytomapXp11.22
Gene Typeprotein-coding
GO ID

GO:0001894

UniProtAcc

Q9BYP7


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
65267WNK3AEH-subject5HumanEndometriumAEH4.12e-04-6.29e-02-0.2953
65267WNK3GSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC4.28e-02-4.60e-02-0.1917
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:190382916EndometriumAEHpositive regulation of cellular protein localization66/2100276/187231.57e-091.36e-0766
GO:007265914EndometriumAEHprotein localization to plasma membrane63/2100284/187237.58e-083.92e-0663
GO:006219716EndometriumAEHcellular response to chemical stress71/2100337/187231.03e-075.05e-0671
GO:003253510EndometriumAEHregulation of cellular component size78/2100383/187231.10e-075.29e-0678
GO:19907789EndometriumAEHprotein localization to cell periphery68/2100333/187236.38e-072.38e-0568
GO:00356337EndometriumAEHmaintenance of blood-brain barrier14/210035/187231.12e-052.52e-0414
GO:19054779EndometriumAEHpositive regulation of protein localization to membrane26/2100106/187238.63e-051.27e-0326
GO:00083616EndometriumAEHregulation of cell size38/2100181/187239.69e-051.40e-0338
GO:190437710EndometriumAEHpositive regulation of protein localization to cell periphery19/210069/187231.49e-041.98e-0319
GO:00510515EndometriumAEHnegative regulation of transport79/2100470/187231.51e-041.99e-0379
GO:000189410EndometriumAEHtissue homeostasis50/2100268/187232.04e-042.54e-0350
GO:19023078EndometriumAEHpositive regulation of sodium ion transmembrane transport9/210021/187232.30e-042.78e-039
GO:19030789EndometriumAEHpositive regulation of protein localization to plasma membrane17/210062/187233.46e-043.80e-0317
GO:00602499EndometriumAEHanatomical structure homeostasis55/2100314/187235.27e-045.32e-0355
GO:19054759EndometriumAEHregulation of protein localization to membrane34/2100175/187239.62e-048.75e-0334
GO:20006518EndometriumAEHpositive regulation of sodium ion transmembrane transporter activity7/210016/187231.01e-038.97e-037
GO:00109597EndometriumAEHregulation of metal ion transport66/2100406/187231.24e-031.07e-0266
GO:00714704EndometriumAEHcellular response to osmotic stress12/210041/187231.35e-031.14e-0212
GO:00712149EndometriumAEHcellular response to abiotic stimulus55/2100331/187231.85e-031.46e-0255
GO:01040049EndometriumAEHcellular response to environmental stimulus55/2100331/187231.85e-031.46e-0255
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
WNK3SNVMissense_Mutationc.4279G>Ap.Glu1427Lysp.E1427KQ9BYP7protein_codingtolerated(0.13)probably_damaging(0.985)TCGA-A1-A0SI-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
WNK3SNVMissense_Mutationc.182N>Gp.Lys61Argp.K61RQ9BYP7protein_codingtolerated(0.14)benign(0.343)TCGA-A8-A081-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
WNK3SNVMissense_Mutationc.4262C>Gp.Ser1421Cysp.S1421CQ9BYP7protein_codingtolerated(0.05)possibly_damaging(0.671)TCGA-A8-A095-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
WNK3SNVMissense_Mutationc.3380N>Cp.Ile1127Thrp.I1127TQ9BYP7protein_codingtolerated(0.46)benign(0)TCGA-A8-A096-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
WNK3SNVMissense_Mutationnovelc.1936N>Gp.Gln646Glup.Q646EQ9BYP7protein_codingdeleterious(0.04)benign(0.003)TCGA-AC-A5XS-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyfemaraSD
WNK3SNVMissense_Mutationrs3747286c.3637G>Ap.Glu1213Lysp.E1213KQ9BYP7protein_codingdeleterious(0.01)possibly_damaging(0.642)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
WNK3SNVMissense_Mutationnovelc.3540G>Tp.Gln1180Hisp.Q1180HQ9BYP7protein_codingdeleterious(0.04)benign(0.259)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
WNK3SNVMissense_Mutationnovelc.2179C>Tp.Arg727Trpp.R727WQ9BYP7protein_codingdeleterious(0)probably_damaging(0.928)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
WNK3SNVMissense_Mutationnovelc.2078T>Cp.Leu693Prop.L693PQ9BYP7protein_codingtolerated(0.18)benign(0)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
WNK3SNVMissense_Mutationc.779N>Ap.Gly260Glup.G260EQ9BYP7protein_codingdeleterious(0)probably_damaging(1)TCGA-BH-A0DQ-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
65267WNK3KINASE, DRUGGABLE GENOME, SERINE THREONINE KINASE, EXTERNAL SIDE OF PLASMA MEMBRANE, ENZYMEinhibitor249565818
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