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Gene: WISP2 |
Gene summary for WISP2 |
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Gene information | Species | Human | Gene symbol | WISP2 | Gene ID | 8839 |
Gene name | cellular communication network factor 5 | |
Gene Alias | CT58 | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | O76076 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8839 | WISP2 | ATC12 | Human | Thyroid | ATC | 2.29e-02 | 1.64e-01 | 0.34 |
8839 | WISP2 | ATC2 | Human | Thyroid | ATC | 3.34e-11 | 1.52e+00 | 0.34 |
8839 | WISP2 | ATC4 | Human | Thyroid | ATC | 3.17e-02 | 1.87e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WISP2 | SNV | Missense_Mutation | c.550N>T | p.Leu184Phe | p.L184F | O76076 | protein_coding | tolerated(0.45) | benign(0.007) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
WISP2 | SNV | Missense_Mutation | rs377297178 | c.172N>T | p.Arg58Trp | p.R58W | O76076 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WISP2 | SNV | Missense_Mutation | c.701C>A | p.Ser234Tyr | p.S234Y | O76076 | protein_coding | deleterious(0.02) | benign(0.186) | TCGA-AY-A54L-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
WISP2 | SNV | Missense_Mutation | rs759003113 | c.65N>A | p.Arg22His | p.R22H | O76076 | protein_coding | deleterious(0.03) | benign(0.022) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WISP2 | SNV | Missense_Mutation | c.310N>A | p.Gly104Ser | p.G104S | O76076 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-CK-5914-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
WISP2 | SNV | Missense_Mutation | c.349N>C | p.Cys117Arg | p.C117R | O76076 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WISP2 | SNV | Missense_Mutation | rs759003113 | c.65N>A | p.Arg22His | p.R22H | O76076 | protein_coding | deleterious(0.03) | benign(0.022) | TCGA-AF-6136-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
WISP2 | SNV | Missense_Mutation | rs763203992 | c.643C>T | p.Arg215Trp | p.R215W | O76076 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-4022-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
WISP2 | SNV | Missense_Mutation | rs757249082 | c.686G>A | p.Arg229His | p.R229H | O76076 | protein_coding | tolerated(0.19) | benign(0.005) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WISP2 | SNV | Missense_Mutation | novel | c.623N>A | p.Cys208Tyr | p.C208Y | O76076 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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