Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: WHSC1L1

Gene summary for WHSC1L1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

WHSC1L1

Gene ID

54904

Gene namenuclear receptor binding SET domain protein 3
Gene AliasKMT3F
Cytomap8p11.23
Gene Typeprotein-coding
GO ID

GO:0000414

UniProtAcc

Q9BZ95


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
54904WHSC1L1HTA11_99999970781_79442HumanColorectumMSS2.14e-336.38e-010.294
54904WHSC1L1HTA11_99999965062_69753HumanColorectumMSI-H1.89e-111.35e+000.3487
54904WHSC1L1HTA11_99999965104_69814HumanColorectumMSS1.30e-491.17e+000.281
54904WHSC1L1HTA11_99999971662_82457HumanColorectumMSS1.98e-499.93e-010.3859
54904WHSC1L1HTA11_99999973899_84307HumanColorectumMSS1.05e-124.47e-010.2585
54904WHSC1L1HTA11_99999974143_84620HumanColorectumMSS6.91e-234.30e-010.3005
54904WHSC1L1AEH-subject1HumanEndometriumAEH1.51e-48-5.83e-01-0.3059
54904WHSC1L1AEH-subject2HumanEndometriumAEH3.36e-37-5.83e-01-0.2525
54904WHSC1L1AEH-subject3HumanEndometriumAEH1.81e-49-5.83e-01-0.2576
54904WHSC1L1AEH-subject4HumanEndometriumAEH4.61e-29-5.83e-01-0.2657
54904WHSC1L1AEH-subject5HumanEndometriumAEH1.81e-49-5.83e-01-0.2953
54904WHSC1L1EEC-subject1HumanEndometriumEEC4.35e-48-5.83e-01-0.2682
54904WHSC1L1EEC-subject2HumanEndometriumEEC4.35e-48-5.83e-01-0.2607
54904WHSC1L1EEC-subject3HumanEndometriumEEC2.45e-51-5.83e-01-0.2525
54904WHSC1L1EEC-subject4HumanEndometriumEEC5.24e-49-5.83e-01-0.2571
54904WHSC1L1EEC-subject5HumanEndometriumEEC1.25e-47-5.83e-01-0.249
54904WHSC1L1GSM5276934HumanEndometriumEEC5.24e-49-5.83e-01-0.0913
54904WHSC1L1GSM5276935HumanEndometriumEEC6.20e-50-5.83e-01-0.123
54904WHSC1L1GSM5276937HumanEndometriumEEC4.59e-35-5.83e-01-0.0897
54904WHSC1L1GSM6177620_NYU_UCEC1_lib1_lib1HumanEndometriumEEC1.17e-30-5.83e-01-0.1869
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa00310ColorectumADLysine degradation27/209263/84651.17e-037.75e-034.94e-0327
hsa003101ColorectumADLysine degradation27/209263/84651.17e-037.75e-034.94e-0327
hsa003102ColorectumMSSLysine degradation24/187563/84652.94e-031.39e-028.50e-0324
hsa003103ColorectumMSSLysine degradation24/187563/84652.94e-031.39e-028.50e-0324
hsa003104ColorectumFAPLysine degradation23/140463/84651.04e-049.46e-045.76e-0423
hsa003105ColorectumFAPLysine degradation23/140463/84651.04e-049.46e-045.76e-0423
hsa003106ColorectumCRCLysine degradation18/109163/84657.21e-046.34e-034.30e-0318
hsa003107ColorectumCRCLysine degradation18/109163/84657.21e-046.34e-034.30e-0318
hsa0031010EsophagusESCCLysine degradation41/420563/84659.63e-032.27e-021.16e-0241
hsa0031013EsophagusESCCLysine degradation41/420563/84659.63e-032.27e-021.16e-0241
hsa003108LiverNAFLDLysine degradation21/104363/84651.09e-053.58e-042.89e-0421
hsa0031011LiverNAFLDLysine degradation21/104363/84651.09e-053.58e-042.89e-0421
hsa0031021LiverCirrhoticLysine degradation29/253063/84654.81e-031.74e-021.07e-0229
hsa0031031LiverCirrhoticLysine degradation29/253063/84654.81e-031.74e-021.07e-0229
hsa0031041LiverHCCLysine degradation47/402063/84651.02e-057.58e-054.22e-0547
hsa0031051LiverHCCLysine degradation47/402063/84651.02e-057.58e-054.22e-0547
hsa003109LungIACLysine degradation17/105363/84651.35e-038.63e-035.73e-0317
hsa0031012LungIACLysine degradation17/105363/84651.35e-038.63e-035.73e-0317
hsa0031022LungAISLysine degradation16/96163/84651.41e-039.49e-036.07e-0316
hsa0031032LungAISLysine degradation16/96163/84651.41e-039.49e-036.07e-0316
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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