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Gene: WDYHV1 |
Gene summary for WDYHV1 |
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Gene information | Species | Human | Gene symbol | WDYHV1 | Gene ID | 55093 |
Gene name | N-terminal glutamine amidase 1 | |
Gene Alias | C8orf32 | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q96HA8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55093 | WDYHV1 | LZE2T | Human | Esophagus | ESCC | 3.21e-02 | 3.70e-01 | 0.082 |
55093 | WDYHV1 | LZE4T | Human | Esophagus | ESCC | 9.15e-10 | 2.16e-01 | 0.0811 |
55093 | WDYHV1 | LZE7T | Human | Esophagus | ESCC | 1.50e-03 | 2.72e-01 | 0.0667 |
55093 | WDYHV1 | LZE8T | Human | Esophagus | ESCC | 4.60e-08 | 2.61e-01 | 0.067 |
55093 | WDYHV1 | LZE20T | Human | Esophagus | ESCC | 1.68e-03 | 2.36e-01 | 0.0662 |
55093 | WDYHV1 | LZE22T | Human | Esophagus | ESCC | 1.35e-04 | 2.35e-01 | 0.068 |
55093 | WDYHV1 | LZE24T | Human | Esophagus | ESCC | 9.63e-13 | 3.76e-01 | 0.0596 |
55093 | WDYHV1 | LZE6T | Human | Esophagus | ESCC | 3.64e-05 | 2.21e-01 | 0.0845 |
55093 | WDYHV1 | P1T-E | Human | Esophagus | ESCC | 3.16e-04 | 1.96e-01 | 0.0875 |
55093 | WDYHV1 | P2T-E | Human | Esophagus | ESCC | 4.25e-25 | 4.18e-01 | 0.1177 |
55093 | WDYHV1 | P4T-E | Human | Esophagus | ESCC | 4.13e-14 | 3.58e-01 | 0.1323 |
55093 | WDYHV1 | P5T-E | Human | Esophagus | ESCC | 2.93e-20 | 3.03e-01 | 0.1327 |
55093 | WDYHV1 | P8T-E | Human | Esophagus | ESCC | 1.74e-06 | 1.47e-01 | 0.0889 |
55093 | WDYHV1 | P9T-E | Human | Esophagus | ESCC | 3.24e-21 | 4.65e-01 | 0.1131 |
55093 | WDYHV1 | P10T-E | Human | Esophagus | ESCC | 1.89e-18 | 2.67e-01 | 0.116 |
55093 | WDYHV1 | P11T-E | Human | Esophagus | ESCC | 4.91e-12 | 3.95e-01 | 0.1426 |
55093 | WDYHV1 | P12T-E | Human | Esophagus | ESCC | 5.57e-22 | 4.42e-01 | 0.1122 |
55093 | WDYHV1 | P15T-E | Human | Esophagus | ESCC | 2.31e-25 | 5.07e-01 | 0.1149 |
55093 | WDYHV1 | P16T-E | Human | Esophagus | ESCC | 1.23e-31 | 6.01e-01 | 0.1153 |
55093 | WDYHV1 | P17T-E | Human | Esophagus | ESCC | 1.96e-09 | 4.37e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDYHV1 | SNV | Missense_Mutation | c.174N>T | p.Glu58Asp | p.E58D | Q96HA8 | protein_coding | tolerated(0.55) | benign(0.001) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WDYHV1 | SNV | Missense_Mutation | rs763903346 | c.236A>T | p.Asp79Val | p.D79V | Q96HA8 | protein_coding | deleterious(0) | possibly_damaging(0.889) | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | |
WDYHV1 | SNV | Missense_Mutation | novel | c.206N>G | p.Ala69Gly | p.A69G | Q96HA8 | protein_coding | tolerated(0.06) | benign(0.12) | TCGA-C8-A26W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
WDYHV1 | SNV | Missense_Mutation | novel | c.494G>A | p.Cys165Tyr | p.C165Y | Q96HA8 | protein_coding | deleterious(0.02) | probably_damaging(0.972) | TCGA-VS-A8EK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
WDYHV1 | SNV | Missense_Mutation | rs755433395 | c.565N>A | p.Ala189Thr | p.A189T | Q96HA8 | protein_coding | tolerated(0.61) | benign(0) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDYHV1 | SNV | Missense_Mutation | c.539G>A | p.Ser180Asn | p.S180N | Q96HA8 | protein_coding | tolerated(0.28) | benign(0.042) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
WDYHV1 | SNV | Missense_Mutation | rs767518368 | c.529G>A | p.Asp177Asn | p.D177N | Q96HA8 | protein_coding | deleterious(0.03) | benign(0.03) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDYHV1 | SNV | Missense_Mutation | novel | c.322N>G | p.Phe108Val | p.F108V | Q96HA8 | protein_coding | deleterious(0.04) | benign(0.068) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
WDYHV1 | insertion | Frame_Shift_Ins | novel | c.167_171dupCTAAT | p.Glu58LeufsTer6 | p.E58Lfs*6 | Q96HA8 | protein_coding | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
WDYHV1 | deletion | Frame_Shift_Del | c.45delN | p.Pro17ArgfsTer31 | p.P17Rfs*31 | Q96HA8 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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